title: Investigating the Effects of Increased ACT11 Expression on Sexual Reproduction and Trichome Branching in Arabidopsis

contributor:
Regan, Sharon
Biology

subject: Arabidopsis

subject: ACT11

abstract: Thesis (Master, Biology) -- Queen's University, 2014-06-24 15:14:59.429

abstract: Activation-tagging is a powerful functional genomics technique used to identify plant genes and their functions. The random introduction of gene enhancers into the plant genome results in the overexpression of nearby genes, thus the gene responsible for a mutant phenotype can be determined based on the location of the enhancers. In a screen for activation-tagged Arabidopsis lines with aberrations in trichome morphology, a mutant (named P330) with unbranched trichomes was identified. In this thesis, the actin- encoding gene ACT11 was found to be upregulated by T-DNA pSKI015 in P330. Additionally, this line also produces a second mutant phenotype, characterized by a significant reduction in seed set. The findings presented in this thesis build upon previous work that has shown ACT11 is strongly expressed in reproductive organs (such as pollen and ovules) and rapidly elongating tissues in Arabidopsis. The role of actin has been characterized in Arabidopsis trichome morphogenesis, however much remains unclear about actin dynamics in sexual reproduction. Our investigation on the effects of increased ACT11 expression adds to our understanding of these processes and also provides the framework for future studies into trichome morphogenesis and sexual reproduction in flowering plants.

abstract: M.Sc.


title: Language Specific Analysis of State Machine Models of Reactive Systems

contributor:
Dingel, Juergen
Computing

rights: This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner.

subject:
software analysis
model checking
Model Driven Development
software engineering

abstract: Thesis (Ph.D, Computing) -- Queen's University, 2014-06-24 17:58:05.973

abstract:
Model Driven Development (MDD) is a paradigm introduced to overcome the complexities of modern software
development. In MDD we use models as a primary artifact that is being developed, tested and refined,
with code being a result of code generation. Analysis and verification of models is an important
aspect of MDD paradigm, because they improve understanding of a developed system and enable discovery of
faults early in the development. Even though many analysis methods exist (e.g., model checking, proof
systems), they are not directly applicable in the context of industrial MDD tools such as
IBM Rational Software Architect Real Time Edition (IBM RSA RTE). One of the main reasons for this
inapplicability is the difference between modeling languages used in MDD tools (e.g. UML-RT language in IBM
RSA RTE) and languages used in existing tools. These differences require an implementation of a transformation
from a modeling language to an input language of a tool.
UML-RT as well as other industrial MMD models, cannot be easily translated, if the target languages do not
directly support key model features.
To address this problem we follow a research direction that deviates from the standard approaches and instead of bringing
MDD models to analysis tools, the approach brings  analysis "closer" to MDD models. We introduce
analysis of UML-RT models dedicated to this modeling language.
To this end we use a formal internal representation of UML-RT models that preserves the important features of
these models, such as hierarchical structures of components, asynchronous communication and action code.
This provides us with formalized models using straightforward transformation. In addition, this approach
enables the use of MDD-specific abstractions aiming to reduce the size of the state space necessary. To this
end we introduce several MDD-specific types of abstractions for: data (using symbolic execution), structure
and behavior. The work also includes model checking algorithms, which use the modular nature of UML-RT models.  The proposed approach is implemented in
a toolset that enables analysis directly of UML-RT models.
We show the results of experiments with UML-RT models developed in-house and obtained
from our industrial partner.

abstract: PhD


title: Homeownership, Geographic Mobility and Mortgage Structure

contributor:
Head, Allen
Lloyd-Ellis, Huw
Economics

subject: Homeownership Default Mobility

abstract: Thesis (Ph.D, Economics) -- Queen's University, 2014-06-24 19:58:17.324

abstract: This thesis studies the impact of geographic mobility on the decision of a household to whether to buy or to rent a house, and sheds light on the efficiency of mortgage default prevention policies. The first chapter provides an introduction and an overview of the ongoing policy debates on homeownership and mortgage terms. In the second and third chapters, I study the housing tenure decision in the context of a life cycle model with uninsurable individual income risk, plausibly calibrated to match key features of the U.S. housing market. I find that the relatively low ownership rate of young households is mainly explained by their high geographic mobility. Downpayment constraints have minor quantitative implications on ownership rates, except for old households. I also find that idiosyncratic earnings uncertainty has a significant impact on ownership rates. Based on these results, I argue that the long term increase in ownership rates observed over the period 1993-2009 was not necessarily due to mortgage market innovations and the relaxation of downpayment requirements, as is often argued. Instead, it was simply an implication of U.S. demographic evolution, most notably the decline in interstate migration and, less importantly, population aging. Finally, in Chapter 4, I study the impact of the relaxation of downpayment requirement on homeownership and default risk. Given its quantitative success in matching the U.S. homeownership curve, my model represents a reasonable benchmark to asses the efficiency of mortgage default prevention policies. I find that both income and mobility are the main trigger factors for default decisions. In fact, households with a higher mobility (ie. young households) rate are more likely to default. According to the welfare analysis, I suggest that policymakers include a minimum downpayment requirement of 9.5% in the new definition of the Qualified Residential Mortgage. This number should, however, be viewed with some caution, since I focus on a steady state economy, in which house prices are constant. In fact, the house price represents an important factor influencing the default rate. Potentially, the optimal minimum downpayment requirement should be set at higher value than 9.5%.

abstract: PhD


title: The Canadian Soldier: Combat Motivation in the Canadian Army, 1943-1945

contributor:
English, Allan
History

subject:
Second World War
Canadian
History
Morale
Combat
Military

abstract: Thesis (Ph.D, History) -- Queen's University, 2014-06-26 10:11:09.86

abstract: This thesis is a study of the combat motivation and morale of infantrymen in the Canadian Army during the Second World War. Using battle experience questionnaires, censorship reports, statistical analyses, operational research, and other contemporary sources, this study offers a “big-picture” look at the human dimensions of warfare as experienced by Canadian infantrymen during the Italian and Northwest Europe campaigns of 1943 to 1945. The myths and realities of who the Canadian soldiers were provides the background, as does an exploration of their training and organization. Each core chapter explores one segment of the Canadian campaigns in Europe: the Sicilian and Italian campaign of 1943, the Italian campaign of 1944-45, the Normandy campaign of the summer of 1944, and the Northwest Europe campaign of 1944-45. Each of these chapters analyzes the force structure, behaviour in battle, morale, cohesion, and motivation of Canadian infantrymen during that particular segment of the campaign, setting them in comparison with one another to demonstrate continuities and change based upon shifting conditions, ground, and circumstances. In doing so, this thesis offers an original interpretation of Canadian combat motivation in the Second World War. Due to high infantry casualty rates, influxes of new reinforcements, and organizational turmoil, Canadian soldiers in many campaigns frequently fought as “strangers-in-arms” alongside unfamiliar faces. In spite of being strangers, however, the Canadians maintained remarkably high levels of cohesion, morale, and effectiveness (despite setbacks and periods of malaise) throughout the fighting. These successes can be attributed to the phenomenon of “swift trust” cohesion, the preservation of NCO leadership even in the face of heavy casualties, and effective training.

abstract: I intend to pursue immediate publication of this thesis as a book manuscript and would prefer that the manuscript become publicly available before the thesis. Additionally, some of my raw data was used with permission from another scholar, based upon research that was done for a forthcoming but still-unpublished study. My strong preference would be that my thesis remain restricted until after their manuscript has been published as well, out of respect for their work.

abstract: PhD


title: Design And Development of Mobile Image Overlay System For Image-Guided Interventions

contributor:
Fichtinger, Gabor
Mechanical and Materials Engineering

subject:
Percutaneous Surgery
Mobile Image Overlay System
Computer Assisted Surgery
Minimally Invasive Surgery
X-ray Vision
Image-Guided Needle Interventions
Biopsies
Image overlay

abstract: Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2014-06-26 18:51:03.958

abstract:
Numerous studies have demonstrated the potential efficacy of percutaneous image-guided interventions over open surgical interventions. The conventional image-guided procedures are limited by the freehand technique, requiring mental 3D registration and hand-eye coordination for needle placement. The outcomes of these procedures are associated with longer duration and increased patient discomfort with high radiation exposure. Previously, a static image overlay system was proposed for aiding needle interventions. Certain drawbacks associated with the static system limited the clinical translation.

To overcome the ergonomic issues and longer calibration duration associated with static system, an adjustable image overlay system was proposed. The system consisted of monitor and semi-transparent mirror, attached together to an articulated mobile arm. The 90-degree mirror-monitor configuration was proposed to improve the physician access around the patient. MicronTracker was integrated for dynamic tracking of the patient and device. A novel method for auto-direct calibration of the virtual image overlay plane was proposed. Due to large mechanical structure, the precise movement was limited and consumed useful space in the procedure room. A mobile image overlay system with reduced system weight and smaller dimensions was proposed to eliminate the need for mechanical structure. A tablet computer and beamsplitter were used as the display device and mirror respectively. An image overlay visualization module of the 3D Slicer was developed to project the correct image slice upon the tablet device.

The system weight was reduced to 1 kg and the image overlay plane tracking precision (0.11mm STD=0.05) was similar to the printed physical markers. The auto-calibration of the image overlay plane can be done in two simple steps, away from the patient table and without additional phantom. Based on the successful pre-clinical testing of the previous static system, the mobile image overlay system with reduced weight, increased tracking precision and easier maneuverability, can be possibly hand-held by the physician to explore the image volume over the patient and be used for a wide range of procedures. The mobile image overlay system shall be classified as Class II device as per FDA regulations, do not require extensive verification and validation efforts and further improves the commercialization opportunities.

abstract: M.A.Sc.


title: Control Techniques for a Single-Phase Bi-Directional Full-Bridge Active Rectifier for Vehicle-to-Grid and Grid-to-Vehicle Applications

contributor:
Jain, Praveen K.
Electrical and Computer Engineering

subject:
Control
Charger
Rectifier
Electric Vehicle
AC/DC
Bi-directional
Nonlinear
Power Electronics
AC-DC

abstract: Thesis (Master, Electrical & Computer Engineering) -- Queen's University, 2014-07-03 19:53:18.153

abstract:
As electric vehicles (EV) continue to gain market traction, more research is being conducted in the control of the power conditioning system. This thesis focuses on control strategies for the front-end AC/DC converter. Current EV chargers in the market are unidirectional which limits the opportunity for EV owners to participate in vehicle –to-grid services. The core work on this thesis is two bi-directionally capable controllers for EV chargers that have improved performance or added functionality over the traditional chargers on the market. The controllers were simulated and implemented on a single-phase full bridge converter.

The first controller focuses on improving the dynamic performance of EV chargers compared to the conventional linearly regulated chargers. This nonlinear controller is designed based on Lyapunov control theory which guarantees that the energy of the system is always decreasing thereby guaranteeing stability. A better version of this controller is designed by adding integral terms into the system. These terms compensate for parameter variations and converter model inaccuracies. Finally, a practical version of the controller is implemented by using the Tikhonov theorem to decouple the fast current loop and the slow voltage loop of the system.

The second part of the thesis focuses on the design of a controller which allows for four quadrant operation of the AC/DC converter by directly controlling the active and reactive power. This will allow EV owners to participate in ancillary services such as voltage control of the grid. This has potential to generate additional revenue for the owners and can also benefit the utility operators. This controller was designed in the synchronous frame using the Alpha-Beta to DQ transformation. In order to design this controller, an orthogonal version of the system had to be created. Several methods of orthogonal signal generation were compared and the one most suitable for this application was used.

The result of this work is two controllers for EV chargers that tackle current challenges that exist in EV chargers. These controllers were simulated in PSIM and experimentally verified on a 1kW single phase full-bridge active rectifier.

abstract: Awaiting publication in journal papers. I need to write the papers which will take a year

abstract: M.A.Sc.


title: IL-27 Enhances LPS-Induced Proinflammatory Responses in Human Monocytes: Augmented Inflammasome Activity and IL-23 Expression

contributor:
Gee, Katrina
Microbiology and Immunology

subject: Inflammation

subject: IL-27

subject: Monocytes

subject: Inflammasome

subject: IL-23

abstract: Thesis (Master, Microbiology & Immunology) -- Queen's University, 2014-06-26 15:18:20.124

abstract: Inflammation plays an important role in responding to injury and combating infections.  In this thesis, I examine how inflammation is regulated by cytokines responsible for driving initial immune responses to combat infections. Toll-Like receptor (TLR)-mediated activation of monocytes, macrophages and dendritic cells can lead to the co-expression of proinflammatory cytokines including IL-1β, IL-23, and IL-27. IL-23 and IL-27 belong to the IL-12 cytokine family yet have distinct functions; IL-23, along with IL-1β, regulates TH17 cell differentiation, while IL-27 supports TH1 proliferation and inhibits TH17 differentiation. Our lab has previously demonstrated that IL-27 can modulate inflammasome activation, the multi-protein regulatory complex that produces bioactive IL-1β; however, the mechanism behind this is poorly understood. Similarly, the effect of IL-27 on IL-23 expression has not been well described. Using the CD14+ THP-1 monocytic cell line as a model system, I investigated the role of IL-27 on LPS-mediated inflammasome activation and IL-23 expression. To induce inflammasome activation, CD14+ THP-1 cells were treated with LPS and/or IL-27, followed by treatment with ATP. I demonstrated that IL-27-enhanced inflammasome activation, which is associated with increased surface expression of LPS and ATP receptors: TLR4 and P2X7 respectively. Furthermore, costimulation resulted in increased secretion of ATP from CD14+ THP-1 cells. Inhibition of ATP signaling and inflammasome activation significantly decreased secreted IL-1β, suggesting that an ATP autocrine feedback loop is driving IL-1β secretion. Moreover, LPS and IL-27 costimulation increased IL-23 expression concurrent with that of IL-1β and ATP secretion. Furthermore I showed that IL-23 secretion is dependent on inflammasome activation and IL-1β, and ATP signaling following IL-27 and LPS priming. My data point to a novel mechanism of IL-27 enhanced LPS-induced IL-1β and IL-23 secretion from CD14+ THP-1 cells through an ATP autocrine feedback loop.

abstract: I would like my thesis to be restricted for an undefined amount of time as my lab is currently trying to publish the findings included in my thesis.

abstract: M.Sc.


title: Examining the influence of physical and health education on ontario grade 9 students' physical activity intentions and behaviours

contributor:
Freeman, John G.
Education

subject:
physical and health education
Theory of Planned Behaviour
physical activity

abstract: Thesis (Master, Education) -- Queen's University, 2014-06-26 15:29:51.422

abstract: Insufficient physical activity and a sedentary lifestyle are major contributors to health risks for Canadian youth. Adolescents, particularly girls, tend to experience major drop-offs in physical activity levels during high school. However, there is minimal research examining the extent to which Physical and Health Education (PHE) courses promote physical activity and mitigate against this decline. Grounded in the Theory of Planned Behaviour (TPB), the purpose of this quantitative short-term longitudinal study is two-pronged: (a) examine the effectiveness of Grade 9 PHE for 197 students’ reports of TPB constructs, physical activity intentions, and physical activity behaviour; and (b) explore the utility of TPB in predicting physical activity intentions and behaviour. For the first set of research questions, results were analyzed using 2 (time: Time Point 1 [T1], Time Point 2 [T2]) x 2 (condition: in PHE/not in PHE) x 2 (TPB status: higher or lower than the mean) MANCOVAs with boys and girls examined separately. There was no effect of PHE over time. There was no interaction among time, condition, and TPB status. There was a significant effect of condition for girls in PHE, with Attitude and Physical Activity Behaviour higher at both time points. For the second set of research questions, results were analyzed using multiple linear regressions to examine TPB in a Grade 9 setting. Findings provided support for the theoretical structure of the TPB in a Grade 9 context, with the three TPB constructs accounting for a minimum of 59% of Intentions, and a minimum of 25% of Behaviour for boys and girls. Attitude was the strongest independent predictor of Intentions with Intentions and Attitude the strongest predictors of Behaviour. PHE teachers should potentially focus attention on changing attitudes for this age group, given the importance of this construct.

abstract: M.Ed.


title: Active Damping of LCL Filter Resonance for a Single Phase Grid-Connected Distributed Power Generation System

contributor:
Bakhshai, Alireza
Electrical and Computer Engineering

subject:
Proportional Resonant Control
LCL Filter Resonance
DPGS
VSCs
Active Damping
Notch Filter

abstract: Thesis (Master, Electrical & Computer Engineering) -- Queen's University, 2014-06-26 17:06:03.693

abstract: This Master of Applied Science thesis presents an inverter control system design and implementation with active damping of LCL filter resonance for a single phase grid-connected Distributed Power Generation (DPGS). The focus of the thesis is to actively damp the LCL filter resonance while keeping inverter control variables well regulated. The mathematical model of the LCL filter is analyzed and the filter is designed. Then, a PLL, and a PI compensator in the synchronous reference frame, and a PR compensator in stationary reference frame along a notch filter in cascade are designed and implemented. System level simulation and implementation are conducted. The idea of systematic applying the low loss power conversion topology, effective grid condition detection, grid synchronization, and advanced signal processing theory provides some advantages for single phase grid-connected inverter control design to meet the standard specifications of the interaction between the DPGS and utility grid.

abstract: I developed some signal processing algorithms adding to the control system, which is superior to the conventional method. I also made some contributions to system design and implementation, which make the system THD of the current injecting to grid going down 0.2% compare to conventional method. A refereed paper based on this dissertation is already accepted for presentation and will be published at IEEE Industrial Electronics Conference (IECON2014). But before that, I am revising the paper and will submit the paper and make it publish as a Journal papers at IEEE Transition. Another reason for restriction is  the commercial interest. I may later apply some patents based on the dissertation.

abstract: M.A.Sc.


title: Strengthening Slender S-Section Steel Columns Using CFRP Plates of Various Moduli

contributor:
MacDougall, Colin
Fam, Amir Z.
Civil Engineering

subject:
Strengthening
Buckling
Weak Axis
Strong Axis
Slender Column
CFRP

abstract: Thesis (Master, Civil Engineering) -- Queen's University, 2014-06-27 15:19:03.397

abstract:
This thesis investigates strengthening slender steel columns with carbon fibre reinforced polymer (CFRP) plates of various moduli.  Three different types of CFRP were used in the study: Ultra-high modulus (430GPa), High modulus (212GPa) and Normal modulus (168GPa).  In this study, specimens were grouped according to measured initial out-of-straightness values.  The first section examines the effect of adding CFRP plates to the column flanges when buckling about the weak axis.  Twelve columns, with a slenderness ratio of 197, were tested, of which nine were strengthened with CFRP.  The main parameters tested were the level of initial out-of-straightness (length (L)/8387 to L/1020), CFRP modulus (168 to 430 GPa), CFRP reinforcement ratio (13% to 34%) and the length of CFRP plate (33% to 95% of L). The gain in axial strength due to CFRP retrofitting ranged from 11% to 29%, depending on the various parameters. The gain generally increased as CFRP modulus, initial out-of-straightness, or CFRP reinforcement ratio increased.  Global buckling consistently governed the maximum load. In the case of the 430 GPa CFRP, buckling was followed by CFRP crushing in compression, then rupture in tension.
The second section of the thesis examines the effect of CFRP plates added to the flanges and tested for buckling in the strong axis.  Eight columns, with a slenderness ratio of 83, were tested of which five were strengthened with CFRP.  The main parameters examined were the level of initial out-of-straightness (L/28889 to L/1635), CFRP modulus (168 to 430 GPa), CFRP reinforcement ratio (13% to 34%) and the axis of bending.  The gain in axial strength due to CFRP retrofitting ranged from 0% to 25%, depending on the various parameters. The gain generally increased as initial out-of-straightness, or CFRP reinforcement ratio increased.  The higher modulus did not perform as expected, showing no gain in strength, because the compressive strains were too large and the CFRP crushed before the specimen experienced any gain.  Specimens compared with the weak axis, strengthened with normal modulus CFRP, had similar percentage gains in strength.

abstract: M.A.Sc.


title: Bronchodilating and Bronchoprotective Effects of Deep Inspirations in Asthma, Cough Variant Asthma, and Methacholine-induced Cough but Normal Airway Sensitivity

contributor:
Lougheed, Diane M.
Fisher, John T.
Physiology

subject:
cough
asthma
deep inspirations
methacholine

abstract: Thesis (Master, Physiology) -- Queen's University, 2014-06-28 11:23:29.814

abstract:
Rationale: The pathophysiologic differences between classic asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) are poorly understood and may relate to differences in small airway function. We hypothesized that the bronchodilating and bronchoprotective effects of DIs are:  (a) absent or impaired in individuals with CA; (b) impaired in individuals with CVA; and (c) preserved in those with COUGH.
Purpose: To compare the effect of DIs in individuals with CA, CVA and COUGH using high-dose methacholine (MCh).
Methods: Individuals aged 18-65 years with CA, or suspected CVA attended 3 visits. On visit 1, subjects performed body plethysmography and high-dose MCh testing to a maximum change (Δ) in FEV1 of 50% from baseline (MAX). On visits 2 and 3, subjects performed one of two modified single-dose MCh challenge tests with or without DIs prior to MCh administration. Partial and maximal-flow volume curves (used to calculated a DI index), impulse oscillometry (IOS) measurements and breathlessness (Borg scale) were recorded at baseline and at each dose of MCh. Lung volumes were measured by body plethysmography at baseline and MAX. Responses from baseline to a 20% decline in FEV1 (PC20) or MAX, and between visits with or without DIs were compared using paired t-tests. Between group differences were assessed by analysis of variance.
Results: 19 subjects (14 female; 45.1±13.1 years (MEAN±SD)) completed the protocol (n=8 CA, n=7 CVA, and n=4 COUGH). At the dose nearest to PC20, the DI index was positive in all 3 groups, indicating preserved bronchodilation (CA: 0.88±0.67; CVA: 0.33±0.39; COUGH:  0.016±0.46; P=.0.076). There were no significant differences in: the Δs in spirometry, lung volumes, airway resistance, IOS measurements, closing indices, the DI index, or dyspnea when the single dose of MCh was preceded either by five DIs or by DI avoidance in CVA and COUGH. DIs in CA resulted in greater Δs in mid-to-late flows.
Conclusion: The bronchodilating effect of DIs is preserved in CA, CVA and COUGH. The bronchoprotective effect may fall along a continuum. A larger study including subjects with more severe CA is required to definitively test the hypotheses.

abstract: This thesis contains preliminary, unpublished data. We are still recruiting to meet the required sample size, and do not want to preclude peer-review publication.

abstract: M.Sc.


title: "The Messy Work": Parenting, Social Reproduction, and Neoliberal Restructuring in Jamaica

contributor:
Mullings, Beverley
Global Development Studies

subject:
Parenting
Jamaica
Caribbean
Neoliberalism
Family
Household
Social Reproduction
Policy Analysis

abstract: Thesis (Master, Global Development Studies) -- Queen's University, 2014-07-04 01:13:24.403

abstract: Examining the emergence and growing popularity of parenting programmes among states and international development agencies, this thesis explores the effectiveness of parenting interventions as a solution to high levels of social disorder, poverty, and violence that influence how poor families survive and carry out the “messy” work of social reproduction. Drawing on a case study of Jamaican parenting programmes and poor young women and men who participate in them, this thesis seeks to explore the relationship between these programmes and the neoliberal development strategies that the country has pursued for the last thirty years. Focusing specifically on the effects of liberalization on everyday practices of social reproduction among the urban poor, I argue that parenting programmes represent an institutional strategy aimed at shaping the behaviour of the poor, rather than addressing the structural causes that contribute to an ongoing crisis of social reproduction. Furthermore, I argue that parenting interventions reproduce racial and gender discourses and practices that target and pathologize poor, black Jamaicans as deficient and dysfunctional. Drawing on a critical policy approach, I contend that parenting cannot solve the larger anxieties created by the limited support given to spaces of social reproduction, especially when there is a commitment to social protection programmes and austerity measures that are encouraged by international institutions. Research findings demonstrate that parenting interventions contribute to positive parent-child relationships and confidence building. However, the daily experiences of parents are still complicated by socioeconomic stressors and structural barriers such as unemployment and poverty. In this context, community organizations also face uncertainty and fatigue in delivering support to parents. The broader significance of this study speaks to the necessity for social reproduction to be given as much priority as economic production in any socially sustainable strategy of development. The study also exemplifies how developing countries are largely controlled through mechanisms of debt servicing and donor funding especially when implementing and allocating collective resources to support families. Thus, a system where parenting intervention is rejected as a sufficient structural solution to collective issues in Jamaica is required in both local and international institutions.

abstract: M.A.


title: Activation of Heme Oxygenase-2 to Improve Outcome After Traumatic Brain Injury

contributor:
Nakatsu, Kanji
Pharmacology and Toxicology

subject:
Controlled Cortical Impact
Beam Balance
Heme Oxygenase
Spontaneous Locomotor Activity
Spontaneous Alternation Behaviour
Traumatic Brain Injury

abstract: Thesis (Master, Pharmacology & Toxicology) -- Queen's University, 2014-06-27 19:33:45.645

abstract: Traumatic brain injury (TBI) is an injury of the brain most often caused by blunt force trauma to the head and typically characterized by an increase in reactive oxygen species (ROS), inflammation, and hemorrhaging. Heme oxygenase (HO) catalyzes the breakdown of heme into carbon monoxide (CO), biliverdin which is further reduced to bilirubin, and ferrous iron. There are two active isoforms: HO-1 which is inducible and found predominantly in liver and spleen tissue; and HO-2 which is constitutive and found predominantly in the brain and testis. The metabolites of heme possess cytoprotective properties that can limit damage resulting from TBI. Our laboratory has found a selective HO-2 activator known as menadione (MD) that has been found to increase HO-2 activity by 4-fold while not affecting HO-1 in vitro. Given the higher amounts of HO-2 found in the brain and the cytoprotective properties of heme metabolites, we postulate that activation of HO-2 using menadione would mitigate further damage after TBI. The rat controlled cortical impact (CCI) model was used to simulate TBI with spontaneous locomotor activity (SLA), spontaneous alternation behaviour (SAB), and beam balance (BB) as the behavioural tasks to assess cognitive and motor function. A dose-response study (25, 50, 100, 200 μmol/kg) was performed to ascertain the effect of MD treatment on injured animals comparing to uninjured controls and injured animals treated with the vehicle (saline). We found that BB performance improved to control levels after MD treatment at 25 μmol/kg and 50 μmol/kg whereas animals treated with saline did not improve. SLA and SAB performance did not improve after treatment with MD. The findings suggest that HO-2 activation may be a viable method in mitigating further injury after TBI.

abstract: M.Sc.


title: The Via Media to Vatican II: Liberalism, Socialism, and Transatlantic Catholic Social Thought, 1912 to 1961

contributor:
McKay, Ian G.
History

subject: Social Catholicism; Catholic Social Thought; Liberal Order Framework; Socialism; Vatican II

abstract: Thesis (Ph.D, History) -- Queen's University, 2014-07-02 14:44:51.06

abstract:
Following the Capture of Rome and suspension of the First Vatican Council in 1870, the Roman Catholic Church, as a global institution, desperately needed to rethink its relationship to modernity.  Catholics had attempted to do so throughout the nineteenth century: applying faith-based principles to matters of social and economic organization and reorienting traditional notions of charity to ones based on social justice.  ‘Social Catholicism’ became a groundswell within the Church, culminating in papal encyclicals such as Rerum Novarum (1891) and later Quadragesimo Anno (1931).  Concurrently, Catholic scholars had been looking to the medieval philosophy of St. Thomas Aquinas for inspiration to confront post-Enlightenment Western Civilization, an initiative reflected by Pope Leo XIII’s Aeterni Patris (1879).  These developments became intertwined.  These encyclicals argued for a ‘third way’ most often associated with an economic and social philosophy of ‘corporatism.’  However, a corporatist reading came alongside other interpretations in Catholic social thought, which included British distributism and French personalism.  Outside of fascist regimes, moreover, the idea of a ‘third way’ must more accurately be repositioned as occupying a ‘liminal’ space between the liberal and socialist traditions.  Within this conceptual space came an engagement with modernity—one which created the preconditions for Vatican II.
	This dynamic affected the universal Church, but, as a via media, one that developed within local and national experiences of Catholicism.  Using this framework, this study explores social Catholicism within English Canada from 1912 to 1961.  It discerns three streams of social Catholic thought and action associated within the Antigonish Movement of Nova Scotia, the work of Henry Somerville in the Archdiocese of Toronto, and the educational initiatives of the Congregation of Priests of St. Basil.  Through these streams, social Catholics experience a space of liminality between a social order predicated on liberalism and attempts by the left to live outside of an established set of economic and social relations conditions created by liberalism and capitalism since the 1840s in Canada.  For the Canadian Church, this engagement leads to intellectual and institutional restructuring—a middle way, experienced in concert with Catholicism throughout the west, which led to the Second Vatican Council.

abstract: The author wishes to publish thesis.  Some scholarly presses prefer thesis not be available electronically in advance of publication.  I request a five-year restriction.

abstract: PhD


title: A Wedding Fit for a Bride: Neoliberal Consumerism, Postfeminism, Dramaturgy and the North-American Wedding

contributor:
Burfoot, Annette J.
Sociology

subject: Postfeminism Consumption Dramaturgy Weddings

abstract: Thesis (Master, Sociology) -- Queen's University, 2014-07-06 22:49:21.545

abstract: Despite declining marriage rates and an increased acceptance of common-law couples in North America (Milan, 2013), the wedding is still constructed  as a meaningful life event through the use of reality wedding shows, which have increased in number in recent years. Wedding-related media, which is funded by the wedding industry, is responsible for communicating the expectations and standards of the modern wedding which couples are expected to follow (Boden, 2001; Engstrom, 2008;2012; Mead, 2007). Bridal media, as wedding-related media is often called, positions brides as the focal point of the wedding and encourages them to create not just a standard wedding but a “perfect” wedding (Engstrom, 2012). This “perfect” wedding is positioned by bridal media as something that all brides can obtain through the purchase of material goods during the process of wedding planning. Given the emphasis placed on individualism in a neoliberal capitalist context (Hasinoff, 2008; Tudor, 2012), while there is a common notion of what the “perfect” wedding includes, each couple is expected to add their own personal touches, so long as they fall within wedding standards. As women are the focal point of the wedding celebration, it is important to consider how consumption-based feminine gender roles and norms effect wedding consumption given the high costs of the “perfect” wedding. For the purposes of this study, a multi-theoretical approach is taken that focuses primarily on Angela McRobbie’s (2009) take on postfeminism and a critical take on Goffman’s dramaturgy (1959; Paolucci & Richardson, 2006). A critical ethnographic content analysis was done using twenty episodes of the reality wedding television series Rich Bride Poor Bride. The findings of the study suggest that women are responsible for driving wedding-related consumption which relates to consumption-based feminine gender roles in the neoliberal postfeminist context. This study also finds that perfection and happiness also relate to wedding spending and tend to be of particular importance to the bride. As the bride becomes the focal point of the wedding, grooms are excluded, although they do wish to be involved.

abstract: M.A.


title: The Response of Discostella Species to Climate Change at the Experimental Lakes Area, Canada

contributor:
Cumming, Brian F.
Biology

subject:
Experimental Lakes Area
Paleolimnology
Climate Change
Diatom
Limnology
Discostella

abstract: Thesis (Ph.D, Biology) -- Queen's University, 2014-06-30 15:03:04.447

abstract:
Global climate change is threatening both our water quality and quantity. Specifically, the influence of climate change on freshwater lakes includes decreased water availability, increased evapotranspiration, changes in nutrient availability, and shifts in species composition. Understanding the changes that are occurring to our freshwater ecosystems is imperative to understanding the full impact of climate change on both the environment and society.
This thesis examines a shift in sedimentary diatom assemblages towards increased relative abundances of Discostella species, a phenomenon that has been documented across the Northern Hemisphere. One of the central tenants of this work is that it has been done at the Experimental Lakes Area (ELA) in the boreal region of Canada, a study site that is uniquely devoid of large-scale anthropogenic disturbances. An analysis of the long-term monitoring records at the ELA show that Discostella species are primarily spring bloomers, and recent increases in their abundance is linked to changes in spring thermal conditions.
To link the changes recorded in the sedimentary records of eight lakes to climate change, and assess whether Discostella species are in fact showing a response to climate change, a novel approach utilizing the theory of temporal synchrony was applied to eight paleo records. Discostella stelligera was found to be synchronous in all eight lakes studied, suggesting that a broad-scale forcing factor is influencing its abundance. Further, it was significantly correlated with annual and winter temperatures, supporting a link to changes in spring thermal conditions as a possible explanation.
To assess the relative sensitivity of the study lakes, particularly in comparison to other boreal and temperate region lakes, an analysis was conducted of the timing of the first change in Discostella species. Several statistical techniques were employed and all approaches showed that the study lakes from ELA responded earlier in comparison to other lakes studied from other boreal and temperate regions (ca. 1900 vs ca. 1970), but later than Arctic and Sub-Arctic lakes. We suggest that this may be due to the lack of local disturbances at the ELA and/or the comparably small size of our study lakes.

abstract: PhD


title: Composing Heterogeneous Services From End Users' Perspective

contributor:
Zou, Ying
Electrical and Computer Engineering

subject:
Mining Online Instructions
End User Programming
Service Composition
Quality of Experience

abstract: Thesis (Ph.D, Electrical & Computer Engineering) -- Queen's University, 2014-06-30 15:18:28.155

abstract:
As the Internet becomes more pervasive, the content and services are increasing in quantity as well as improving in quality. This trend is fostered by the advancement of technologies, such as RESTful services, Web 2.0, and Mashups. Service composition integrates services to fulfill specific tasks using a set of tools. The existing service composition techniques and tools are mainly designed for the Service Oriented Architecture (SOA) professionals. The business processes used in the service composition systems are primarily designed by business analysts who have extensive process knowledge. Due to the lack of process knowledge, novice business analysts and end users face challenge to identify and orchestrate service into a well-defined business process. Even for the experienced users, it is challenging to select appropriate services from a set of functionally similar services as the quality information of services may not be available.

In this thesis, we propose a framework that allows a non-technical user to combine web services to achieve a goal. Our approach helps users to find the process knowledge from the web. We index web services based on the semantic concepts available in the service description documents and help users to formulate a web service search query. We use online reviews to choose a web service from a set of functionally similar web services. Our approach automatically finds the data flow between web services and generates a user interface to execute a composite service. The effectiveness of our proposed approaches is demonstrated through a series of case studies. The results of our case studies show that our approaches for process knowledge extraction, service discovery, and service selection make it easier for people with less technical knowledge to compose services.

abstract: PhD


title: Vicarious Exposure to Male Sexual Harassment: Correlates, Perceived Motives and Ethical Evaluations, & Behavioral Responses

contributor:
Barling, Julian
Management

subject:
Sexual Harassment
Male Targets
Observer Experiences

abstract: Thesis (Ph.D, Management) -- Queen's University, 2014-07-05 13:17:17.975

abstract: Despite the increasing attention given to the issue of sexual harassment by organizational scholars, important questions remain unanswered, particularly when it comes to the unique experiences of those who witness the sex-based mistreatment of their peers. Further still, as the sexual harassment of males has only recently captured the attention of researchers, much remains to be learned about situations involving this form of sexual harassment. My dissertation focuses on employees who witness the sex-based mistreatment of their male colleagues. More specifically, three studies focus on same-sex (male-on-male) and/or opposite-sex (female-on-male) male sexual harassment and the impact that observing this phenomenon has on female and male employees. First, I examine how witnessing the sexual harassment of a male colleague impacts one’s well-being, emotions, and collective self-esteem. Second, I investigate what observers of male sexual harassment believe motivates an aggressor to harass a male colleague, and how such beliefs are impacted by (a) the form of the harassment they witness, and (b) who perpetrates this harassment. Demonstrating what conditions will lead to an evaluation of a male sexual harassment incident as unethical is also a primary goal of this investigation. Last, I explore the behavioral responses of witnesses to male-on-male gender harassment. More specifically, I aim to identify factors that affect whether observers will choose to intervene on behalf of the target, or participate in the male sexual harassment that they witness.

abstract: PhD


title: Solar Hot Water Heater Augmented with PV-TEM Heat Pump

contributor:
Harrison, Stephen J.
Mechanical and Materials Engineering

subject:
solar thermal
heat pump
SDHW
photovoltaic
PV/T
domestic hot water
solar assisted heat pump
thermoelectric
solar
energy efficiency

abstract: Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2014-07-03 19:45:51.113

abstract:
Solar assisted heat pumps (SAHPs) can provide higher collector efficiencies and solar fractions when compared against standard solar hot water heaters. Vapour compression (VC) heat pumps require environmentally hazardous refrigerants and moving parts which increase maintenance costs and place limits on operating conditions. Thermoelectric modules (TEMs) use solid state electronics to pump heat without moving parts or refrigerants. This study investigated the performance of a SAHP system utilizing an array of thermoelectric modules as the heat pump.
A component model was developed to simulate the TEM heat pump performance using TRNSYS software and results were compared against those determined experimentally. A simplified model was unable to accurately predict TEM performance. The model was therefore refined to incorporate empirically determined parameters. An apparatus was constructed to measure the performance of a small photovoltaic array driven TEM heat pump and simulation results using the component model were found to be in agreement.
Several SAHP configurations were simulated using TRNSYS and compared with vapour compression SAHPs previously studied at the QSCL. The TEM ISAHP provided a Free Energy Ratio (FER) of 46% and a collector efficiency of 36% whereas the VC ISAHP provided 54% and 76% respectively. The photovoltaic (PV) driven ISAHP system was able to achieve a higher FER of 50% with the use of a 2 module PV array and a reduced thermal collector area.
Further optimization is required to improve TEM heat pump performance in this configuration and reduce the photovoltaic array size. The use of a maximum power point tracker into the PV/TEM system should be investigated as panel efficiency losses reached up to 30% in the configuration studied. The possibility of incorporating combined PV/T modules could decrease costs and also warrants further study.

Critical factors in the success of a TEM driven solar assisted heat pump will include the improvement of thermoelectric materials performance, the optimization of TEM modules for efficient heat pumping applications, and the design of high performance heat exchangers for the TEM heat pump hot and cold faces.

abstract: Elements of my thesis are currently being reviewed for potential intellectual property opportunities.

abstract: M.A.Sc.


title: Mercury Biomagnification in Subtropical Reservoirs of Eastern China

contributor:
Campbell, Linda M.
Wang, Yuxiang S.
Biology

subject:
Limnology
Reservoirs
Aquatic Food Webs
Mercury
Subtropics
Asian Carp
Ecotoxicology
China
Stable Isotopes

abstract: Thesis (Ph.D, Biology) -- Queen's University, 2014-07-01 11:35:12.637

abstract:
Mercury (Hg) is a global pollutant, yet Hg biomagnification, the increase in Hg with trophic level, remains poorly characterized in many regions, especially at subtropical latitudes. The present study assessed subtropical reservoirs of eastern China, which provided an opportunity to quantify Hg biomagnification under highly altered conditions that included high atmospheric Hg deposition, use of reservoirs for fisheries, manipulation of food webs through stocking and high fishing pressure, and increasing eutrophication. Despite China’s Hg emission and deposition rates that are among the highest worldwide, low fish Hg concentrations and Hg biomagnification rates were found; this was explained by food web structure and fish species characteristics. Stocked species occupied lower trophic levels and had significantly lower Hg concentrations relative to wild fishes. Evidence of decreased Hg concentrations with eutrophication (as indicated by chlorophyll-a) was observed, suggesting algal biodilution and/or somatic growth dilution. Relative to temperate lakes, zooplankton density dilution may also be causing reduced Hg concentrations in subtropical biota. Hydrogeomorphic features, such as water retention time and percent crop cover, explained Hg bioaccumulation factors and Hg concentrations at the base of the food web. Eutrophication and hydrogeomorphic features also influenced the bioavailability of selenium, which can protect against the toxicity of Hg at adequate concentrations, and the concentration of eicosapentaenoic acid, a beneficial fatty acid, in the planktivorous Bighead Carp (Hypophthalmichthys nobilis). This may indicate that the risk of exposure to the neurotoxicant methylmercury relative to
benefits of fish consumption may increase with eutrophication in some fish species. Overall, the findings of this study suggest food web structure, eutrophication, and hydrogeomorphic features together explain low Hg concentrations in anthropogenically modified subtropical reservoirs in eastern China.

abstract: PhD


title: Working-Class Anguish and Revolutionary Indignation: The Making of Radical and Socialist Unemployment Movements in Canada, 1875-1928

subject:
Unemployment Protest
Veterans
Anti-Poverty
Canadian Left
Labour
Liberal Order
Canadian History
Social Movements
Socialist Feminism
Capitalism
Immigration
Whiteness and Race

abstract: Thesis (Ph.D, History) -- Queen's University, 2014-07-03 11:57:13.908

abstract: Taking a telescopic view of the multifaceted struggles of the workless prior to Black Tuesday challenges the myopic picture of the Great Depression as the sudden, unexpected eruption of unemployment protest.  Out of all proportion to their size and political strength, radical unemployment agitators between 1875-1928 proved to be vital protagonists in forcing relief measures, thrusting socialist values into public discourse and inspiring working-class resistance during economic crises and at times when the labour movement was at its weakest.  This dissertation examines hundreds of unemployment protests in urban centres across Canada during the 1872-1896 long depression, and the economic slumps of 1907-1909, 1912-1915 and 1921-1926.  These protests and the organizations of the workless challenged three distinct but overlapping stages in the evolution of the liberal-capitalist state: producer, progressive, and authoritarian.  Although always vulnerable and contingent, the mobilized workless responded with innovation to the evolution of liberal capitalism and, by gravitating towards the developing socialist alternative, gained greater coherence and uniformity as they moved from the local and spontaneous “les Misérables” (1875-1896) to an ad hoc “Organized Mob” (1907-1915) to a militant and sporadically nationally-organized “Unemployed Army” (1919-1935).  This study contends that the persistence of a moral economy, the strategies of disruption, and working-class anguish and indignation were key resources for the radical and socialist organizers of the unemployed.  Sensitive to the ways in which a culture of whiteness and masculinity often precluded greater solidarity amongst the workless, this dissertation also traces the ways unemployed diaspora socialists, socialist feminists and their allies encouraged a more diverse and inclusive movement.  Far from reactionary or apathetic, the mobilized unemployed were every bit as important to the vitality of the left as unions or political parties – their struggles were crucial elements in the development of Canada’s earliest socialist experiments.  Similarly, Canadian social policy history is unintelligible without an acknowledgment of the fundamental role that unemployment movements played in wresting concessions from the liberal order and as disruptive agents in the shaping of the welfare state.

abstract: This dissertation will be turned into a published book within two years.

abstract: PhD


title: The Influence of Alcohol Consumption, Smoking, and Physical Activity on Peripheral Blood Leukocyte Telomere Length

contributor:
King, Will D.
Massey, Thomas E.
Community Health and Epidemiology

subject:
Biomarker
Lifestyle
Epidemiology
Alcohol
Smoking
Telomere length
Physical activity
Lifestyle
Cancer

abstract: Thesis (Master, Community Health & Epidemiology) -- Queen's University, 2014-07-08 15:49:30.445

abstract: BACKGROUND: Telomeres are repetitive DNA sequences and associated proteins that cap the ends of chromosomes. Functional telomeres protect genetic information and maintain chromosomal stability. Critically short telomeres are associated with an increased risk of cancer. Telomeres shorten at every DNA replication and due to the nature of their molecular structures are also particularly sensitive to oxidative damage. Consequently, oxidative stress accelerates age-dependent telomere shortening. Certain lifestyle factors affect the oxidant/anti-oxidant balance and can promote oxidative stress. The objectives of this thesis were to determine the effect of alcohol, smoking and physical activity on telomere length in a healthy adult population and to explore an interaction with CYP2E1 and alcohol on telomere length. METHODS: A cross-sectional study design was used to recruit 678 healthy volunteers from 2006 to 2008 from Kingston and Ottawa, Ontario, and Halifax, Nova Scotia. This sub-study included 477 individuals with an available DNA sample and complete questionnaire data. Alcohol consumption, smoking and physical activity were assessed by self-administered questionnaire and CYP2E1 was genotyped by the TaqMan® drug metabolism genotyping assay in the larger study. Relative leukocyte telomere length was measured using multiplex quantitative real-time PCR. Multiple linear regression was used to determine the effect of lifestyle on telomere length while controlling for important covariates. Effect modification by CYP2E1 genotype, specifically the CYP2E1*5B polymorphism, in relation to alcohol was investigated by the inclusion of a product term in the model. RESULTS: Alcohol consumption was not associated with telomere length. The interaction with CYP2E1 was not statistically significant; however, the effect of alcohol on telomere length was qualitatively stronger among those with the normal form of CYP2E1. Current smoking and pack-years smoking were inversely related to telomere length. After adjustment for confounders telomere length was not associated with total physical activity; however, higher vigorous physical activity was associated with longer telomeres. CONCLUSIONS: In recent years, research has demonstrated a relationship between shorter telomeres and age-related diseases, including many forms of cancer. This study found that smoking was inversely associated and vigorous physical activity was positively associated with leukocyte telomere length.

abstract: Restricted to allow time for publication in a peer-reviewed scientific journal.

abstract: M.Sc.


title: Troubling Dominant Discourses: Developing A Framework Of Subversion And Applying It To  Autonomous Activism

contributor:
Krull, Catherine
Burfoot, Annette J.
Sociology

subject:
Subversion
Social Movements
Indigenous
Abjection
Resistance
Solidarity
Judith Butler
Abject
Julia Kristeva
Performativity
Autonomous Activism
Idle No More

abstract: Thesis (Ph.D, Sociology) -- Queen's University, 2014-07-11 14:54:45.358

abstract: My dissertation conducts a conceptual investigation into Judith Butler’s (1990/1999,1993) theory of performativity and Julia Kristeva’s (1982) theorizing on the abject. I use the concepts gleaned from my theoretical exploration to construct an analytical framework that offers ways of explaining the subversion of dominant discourses in the context of autonomous activism. The purpose of this endeavour is to develop a framework for how activist practices can be both more fully autonomous from – and more effectively subversive to – dominant discourses. I apply my framework to the autonomous elements within the Idle No More Movement in order to elucidate the subversive potential of this type of activism for subverting dominant discourses and how it can be strengthened. This application does not seek to define or analyze the movement itself, but rather to offer an explanation for the repression of autonomous-based activism within mainstream Canada. Overall, I find that activism within Western society is caught up in a discursive struggle whereby the suppression of social movements is enacted, in part, through a multitude of abjection processes that are executed through such practices as social interactions, psychological mechanisms, written text, and visual representations. In order to work against this abjection, I develop and present a subversive strategy that calls for the performative repetition of what is abject to dominant discourses.

abstract: I wish to protect my rights to commercial publication at this time.

abstract: PhD


title: The Influence of Toxic Metals on Small for Gestational Age

contributor:
Arbuckle, Tye
King, Will D.
Community Health and Epidemiology

subject:
Cadmium
Mercury
Small for gestational age
Metals
Arsenic
Pregnancy
Gene environment interaction
Biomonitoring

abstract: Thesis (Master, Community Health & Epidemiology) -- Queen's University, 2014-07-10 13:12:06.611

abstract:
Background/Purpose/Objectives: The purpose of this research is to determine the relationship between metal exposure during the first and third trimesters of pregnancy and the risk of small for gestational age (SGA). Size for gestational age is an important predictor of early childhood morbidity and mortality. Genetic polymorphisms in glutathione s transferase omega 1 (GSTO1) and pi 1 (GSTP1) were explored as possible effect modifiers of this relationship. Study Design/Methods: This research is nested within a larger study called The Maternal-Infant Research on Environmental Chemicals (MIREC) Study. The MIREC study is a biomonitoring study being conducted by Health Canada, the Sainte Justine hospital in Montreal, and clinical researchers from various other cities. The study population is a sample of 2000 pregnant women, recruited during the first trimester of pregnancy from across Canada between 2007 and 2011. Blood lead, cadmium, mercury and arsenic were all measured in the first and third trimesters of pregnancy. Arsenic in urine was measured in the first trimester. A log binomial regression model was used to investigate the relationship of interest. Product terms were used to explore the gene polymorphisms. Results: No association was found between blood lead, cadmium or arsenic and risk for SGA. Increased risk for SGA was observed between the ≤.0.8 µg/L and the ≥1.6 µg/L exposure groups for mercury (RR=1.56; 95% CI = 1.04-2.58) and, between the ≥22.56 µg/L and ≤.75 µg/L exposure groups for arsenobetaine (RR= 1.65; 95% CI = 1.10-2.47) after adjustment for the effects of parity and smoking. A marginally significant interaction was observed between the GSTP1 polymorphism and blood lead level in relation to risk for SGA (p for interaction =0.06). No other SNPs were found to modify the relationship between any metal exposure and SGA risk.
 Conclusions: These results suggest that increased levels of mercury in a pregnant woman’s blood or of arsenobetaine in a pregnant woman’s urine, are associated with giving birth to an infant that is SGA. These results are suggestive of increased risk for an adverse effect of low-level lead exposure during pregnancy on fetal size in those with the GSTP1A114V variant genotype.

abstract: I would like to try to publish my manuscript

abstract: M.Sc.


title: Control System Design for Networked Telerobotic Systems

contributor:
Hashtrudi-Zaad, Keyvan
Electrical and Computer Engineering

subject: Robotics Haptics Teleoperation Stability

abstract: Thesis (Ph.D, Electrical & Computer Engineering) -- Queen's University, 2014-07-09 11:51:51.171

abstract:
Telerobotic systems are designed to extend the manipulation capability of users at different scales to remote and dangerous environments. In the past decade, the availability of higher computational power, larger variety of commercial haptic devices and faster means of communication at lower costs have facilitated the rapid development of haptic technology and new applications that would require an interconnection of more than one master and slave. Examples of such applications are telementoring of surgical residents and dual-arm tele-manipulation of objects. These networked systems are dynamically involved and are often represented by multi-port networks; as such, the coupled stability analysis and the design of multilateral controllers for these systems pose a great challenge. This thesis proposes new stability analysis tools and control architectures for networked telerobotic systems, modelled by lumped multi-port networks, distributed multi-port networks, and a cascade of two-port networks.

The first methodology deals with extending the Zeheb-Walach absolute stability theorem, originally developed for microwave systems, to robotic systems represented by a lumped network. The extended Zeheb-Walach theorem allows for studying a larger class of networks with marginal stability, such as robotic systems with position feedback. In the second methodology, a distributed framework for the development of a stability-guaranteed telerobotic system with any number of masters and slaves is proposed. The proposed architecture allows for any number of master or slave networks, all connected to a simple sharing protocol that governs the dynamic interaction among them. Modular stability analysis of each master or slave network, regardless of the underlying sharing paradigm, is conducted using the notion of absolute k-stability. In the third approach, Mobius transformation is used to develop a chain-wise stability analysis methodology to verify the coupled stability of a cascade of networks. The proposed methodology tracks the transmitted passivity unit disk of the load through the cascade to the user network and allows for networks in the cascade that are not passive nor absolutely stable. Due to the modularity of this methodology, it is more suitable for dynamic distributed systems in which a network block in the cascade is modified, added or taken out.

abstract: PhD


title: Théodule Augustin Ribot: The Impact of Spanish Painting on the Artist's Work and Criticism

contributor:
Schütze, Sebastian
Art History

subject: Nineteenth-century French Painting Théodule Ribot

subject: Seventeenth-century Spanish painting Naturalism Realism

abstract: Thesis (Ph.D, Art History) -- Queen's University, 2014-07-03 14:09:38.016

abstract: It is well established that throughout the nineteenth century Spanish painting of the Golden Age played a central role in the formulation of the painterly idioms of French artists that adhered to diverging, even opposed, styles of painting. Spanish motifs in painting were championed by artists like Manet and the painterly techniques of these Old Masters became a fertile source of inspiration for artists like Courbet. Less recognized, however, are the complexity and implications of the relationship between French painters and Spanish painting and the highly personal character of such a relationship. The work of Théodule Augustin Ribot (1823-1891) demonstrates a peculiarly steadfast debt to the Spanish Old Masters. A close study of his oeuvre provides valuable insight into the nature of his relationship with Spanish painting. Conversely, it also elucidates the concerns and tensions imbricated in the relationships of his artist-friends, the critics that assessed his work, and the collectors that owned some of France’s most magnificent displays of Spanish painting, with Spanish painting. At a time when a young generation of artists searching for truthfulness and verisimilitude turned to the Spanish Old Masters for their compelling renditions of Saints and beggars; at a time when Spanish painting became a viable alternative to the classicizing motifs endorsed by the Academy; at a time when the search for a new national art conclusively impacted the relationships between artists and the art of the past; at a time when France’s interventionist policy in Spain congealed into an unprecedented influx of Spanish paintings in France; at such a time, what did it mean for Ribot to so steadfastly inform his work with Spanish painting? This dissertation focuses on the ways in which Spanish painting impacted the work of Ribot and in so doing it complicates established notions on the relationship between seventeenth-century Spanish painting and French painting of the nineteenth century.

abstract: Please restrict online publication of this dissertation for five (5) years to allow for its publication in book form.

abstract: PhD


title: The use of high pressure carbon dioxide for in situ product recovery of butyric acid in a two phase partitioning bioreactor

contributor:
Daugulis, Andrew J.
Chemical Engineering

subject:
in situ product recovery
Two-phase partitioning bioreactor
butyric acid
Clostridium tyrobutyricum

abstract: Thesis (Ph.D, Chemical Engineering) -- Queen's University, 2014-08-21 20:18:18.356

abstract:
The production of organic acids in solid-liquid two-phase partitioning bioreactors (TPPBs) is challenging, as acids absorb into amorphous polymers only in their undissociated form. Thus, at near-neutral fermentation pH values, where dissociated conjugate base species are dominant, partitioning is restricted. This thesis utilizes high pressure CO2 to achieve temporary pH reductions during the production of butyric acid (pKa=4.8) by Clostridium tyrobutyricum, permitting acid absorption and in situ product recovery (ISPR), reducing end-product inhibition and improving fermentative performance.
A growth medium with minimized buffering was developed which did not interfere with pH reductions, and using CO2 sparging a pH of 4.8 was achieved, compared to 5.3 in the original medium, with no difference in cell growth. Buffering from the accumulation of butyric acid during fermentation was observed, however, ISPR of butyric acid was demonstrated using CO2 at atmospheric pressure, yet this did not achieve improvements in reactor performance, and it was concluded that high pressure CO2 may overcome buffering to improve recovery.
To determine what pH would need to be reached with CO2, a first-principles study of pH-dependent partitioning was performed, identifying partition coefficient (PC), polymer fraction (F) and pH as variables for determining organic acid recovery. Through polymer screening based on thermodynamic affinity for butyric acid, an absorptive polymer was selected (Pebax®2533), and partitioning tests for both butyric acid (PC=4.2) and benzoic acid (PC=70, pKa=4.2) validated pH-dependent partitioning models. 60 bar pCO2 was shown to achieve up to 40% recovery of butyric acid, yielding a distribution coefficient (D) of 1.8, and 90% recovery of benzoic acid (D=24), demonstrating clear improvement over atmospheric pressures.
Finally, exposure of cell populations to 60 bar pCO2 showed no adverse biological effect, and at this pressure medium buffering effects were substantially overcome. During fed-batch production of butyric acid the use of high pCO2 provided the necessary pH reductions to achieve substantial acid recovery during fed-batch production of butyric acid, as overall yields, titres, and volumetric productivities were increased by 35%, 60%, and 96%, respectively. High pCO2 represents a novel method for achieving ISPR of butyric acid, which could be extended to the production of other organic acids.

abstract: PhD


title: On Malliavin Calculus and Concentration Inequalities

contributor:
Mansouri, Abdol-Reza
Mathematics and Statistics

subject:
concentration inequalities
Malliavin calculus

abstract: Thesis (Master, Mathematics & Statistics) -- Queen's University, 2014-07-03 23:31:55.967

abstract: We prove new abstract results concerning concentration inequalities and density estimates for Malliavin differentiable random variables. The efficacy of these results are demonstrated by practical computations, such as the calculation of novel concentration inequalities for $Z = \max_{1 \leq i \leq n} N_i - E\left[ \max_{1 \leq i \leq n} N_i \right]$ where the $\{N_i\}_{i=1, ..., n}$ are Normal random variables, and $\int_0^1 B_s^4 ds - \frac{3}{4H+1}$ where $\{B_s, s \in [0,1] \}$ is a fractional Brownian motion with Hurst parameter $H$, as well as the derivation of non-asymptotic confidence intervals for the Hurst parameter of a fractional Brownian motion.

abstract: M.Sc.


title: Guarding the City Beautiful: Liberalism, Empire, Labour, and Civic Identity in Hamilton, Ontario, 1929-53

subject:
Social History
Hamilton, Ontario
Political History
Municipal Governance
Canadian History

abstract: Thesis (Ph.D, History) -- Queen's University, 2014-07-08 15:07:34.687

abstract: Hamilton, Ontario has provided a testing ground for social historians exploring questions about labour, working-class conflict, and shop-floor politics. These studies, though extensive, have largely overlooked the political culture of the city, especially outside these boundaries. Despite the hopes of its left-wing political parties, mid-twentieth century Hamilton fostered a flourishing political culture centred on the rhetoric of traditional liberalism. This political rhetoric was nurtured by the dominant Conservative Party politicians, the traditional trades and crafts-based union movement, a growing middle class, and fervent boosters. This political tradition was strongly informed by the shared British heritage touted by these same groups. These ideals were flexible and mutable, which allowed them to be adopted with versatility as the political climate demanded. This dissertation examines how this political culture survived through decades of economic, social, and labour unrest between 1929 and 1953. Through focusing on municipal government and local politics, this dissertation is able to explore how these political ideals were incorporated in practice, and repeated and reformed in the city’s many elections. This exploration incorporates questions about how these political ideals responded to the inclusion of women, immigrants, and the growing labour movement. It also traces how these values were adapted to suit the political climate of the Great Depression, Second World War, and the post-1946 labour crises that rocked the city’s industries and shaped collective bargaining practice across the country.

abstract: This dissertation is to be restricted to prevent any difficulties in finding a willing commercial publisher following its completion.

abstract: PhD


title: Giuseppe Arcimboldo’s Composite Portraits and the Alchemical Universe of the Early Modern Habsburg Court (1546-1612)

contributor:
Hoeniger, Cathleen
Art History

subject:
Rudolf II
Arcimboldo
Maximillian II
Alchemy
Habsburg

abstract: Thesis (Master, Art History) -- Queen's University, 2014-07-09 19:46:40.606

abstract:
At the Renaissance noble court, particularly in the principalities of the Holy Roman Empire, alchemical pursuits were wildly popular and encouraged. By the reign of Rudolf II in the late sixteenth century, Prague had become synonymous with the study of alchemy, as the emperor, renowned for his interest in natural magic, welcomed numerous influential alchemists from across Europe to his imperial residence and private laboratory. Given the prevalence of alchemical activities and the ubiquity of the occult at the Habsburg court, it seems plausible that the art growing out of this context would have been shaped by this unique intellectual climate.
In 1562, Giuseppe Arcimboldo, a previously little-known designer of windows and frescoes from Milan, was summoned across the Alps by Ferdinand I to fulfil the role of court portraitist in Vienna.  Over the span of a quarter-century, Arcimboldo continued to serve faithfully the Habsburg family, working in various capacities for Maximilian II and later for his successor, Rudolf II, in Prague. As Arcimboldo developed artistically at the Habsburg court, he gained tremendous recognition for his composite portraits, artworks for which he is most well-known today. Through a focused investigation of his Four Seasons, Four Elements, and Vertumnus, a portrait of Rudolf II under the guise of the god of seasons and transformation, an attempt will be made to reveal the alchemical undercurrents present in Arcimboldo’s work. This is not to say that Arcimboldo’s puzzle portraits reference specific alchemical treatises, or that the artist participated actively in alchemical experiments. Rather, in their transformative configuration and subject matter, Arcimboldo’s composite portraits reflect the very ethos of alchemical philosophy and spirituality that so permeated the early modern Habsburg court, an intellectual environment to which he belonged and contributed for a considerable span of time.

abstract: M.A.


title: Urml: A textual toolkit for teaching model-driven development for reactive systems

contributor:
Dingel, Juergen
Computing

subject:
education
model-driven development

abstract: Thesis (Master, Computing) -- Queen's University, 2014-07-09 00:04:30.225

abstract: Modelling is widely used in traditional engineering. Models also serve as the founda- tion of theoretical computer science—from computational models to formal languages. However, even though software designers use formal systems of software, a dominant modelling methodology—model-driven development (MDD)—has not yet penetrated into the industry. This can be attributed to the practitioners’ flawed understanding of the benefits of MDD, the practitioners’ programming-centric mindset, and current complex and expensive tools. Thus, this project aims at providing education and simple tools for the public to appreciate MDD. The product of this project is Urml, which is an educational toolkit for utilizing MDD to develop models for reactive sys- tems. There are four steps in using this toolkit: first, one specifies the metamodel that serves as the language to build models; secondly, one builds a model for reactive systems using the language that one has built; thirdly, one analyzes the model for cor- rectness and consistency; and fourthly, one executes the model for testing through a custom-made interpreter. These four steps—(1) language design, (2) model building, (3) model analysis, and (4) model execution—serve as the pillar of MDD and thus provide students a comprehensive overview of what MDD entails. This toolkit is com- plemented with identifications of extensions and customizations suitable as student projects in a graduate course in MDD.

abstract: M.Sc.


title: Optimum ML Detection for DF Cooperative Diversity Networks in the Presence of Interference

contributor:
Kim, Il-Min
Electrical and Computer Engineering

subject: DF Detection Interference ML

abstract: Thesis (Master, Electrical & Computer Engineering) -- Queen's University, 2014-07-09 11:59:42.106

abstract:
Unlike the existing detectors for decode-and-forward (DF) relaying in the ideal case
without interference, this thesis considers a more practical scenario where arbitrary
interference is present. We consider a DF cooperative diversity network consisting of
one source, multiple relays, one destination and multiple interferers affecting the relays
as well as the destination. Under this scenario, for the  first time in the literature, we develop the exact closed-form rules for optimum maximum-likelihood (ML) detectors
for DF systems employing any one- or two-dimensional modulations in the presence
of interference. In particular, we derive the optimum ML detection rules for two
transmission schemes: simultaneous transmission and orthogonal transmission. In
each transmission scheme, we derive the detection rules by considering two different
cases of the instantaneous channel state information (CSI): the CSI of the second-hop
is known or unknown at the relays. Numerical results demonstrate that the developed
optimum detectors significantly outperform the conventional detector which simply
ignores the existence of interference.

abstract: M.A.Sc.


title: Essays in Banking and Finance

contributor:
Koeppl, Thorsten V.
Milne, Frank
Zabojnik, Jan
Economics

subject:
Banking
Finance
Dynamics Mechanism Design

abstract: Thesis (Ph.D, Economics) -- Queen's University, 2014-07-14 17:33:45.33

abstract: This dissertation examines the design of regulation for financial institutions fol- lowing the financial crisis of 2008-2009. In the aftermath of the crisis, regulators in many countries tightened regulations governing financial institutions in order to pre- vent future financial panics. The aim of this dissertation is to determine how some of these new regulations will influence the behaviour of financial institutions, and if these regulations will result in a safer and sounder financial system.

abstract: I am preparing several chapters for publication so I would like to restrict access to these for now.

abstract: PhD


title: Study of Sorption, Heat and Mass Transfer  During Condensed Mode Operation of Gas Phase Ethylene Polymerization on Supported Catalyst

contributor:
McKenna, Timothy F. L.
Guay, Martin
Boisson, Christophe
Chemical Engineering

subject:
condensed mode
gas phase ethylene polymerization

abstract: Thesis (Ph.D, Chemical Engineering) -- Queen's University, 2014-07-15 10:58:25.693

abstract:
In the current thesis study it is intended to investigate the potential effect of the inert condensing agent (ICA) of n-hexane used in condensed mode operation on the solubility of ethylene in produced polyethylene (PE) and consequently the quality and rate of gas phase ethylene polymerization on supported catalyst under reactive conditions. This is the first time for such a study. Performing the set of designed polymerization reaction experiments using a lab-scale stirred-bed gas phase reactor, it is observed that the instantaneous rate of ethylene polymerization increases in the presence of n-hexane, thus supporting the initial speculation of the effect of n-hexane on the enhancement of the ethylene solubility in polymer known as “cosolubility” phenomenon. In order to have a better picture and understanding, the averaged instantaneous rate of polymerization in presence of n-hexane is normalized with the one without any n-hexane. Consequently, this helps to see that while the effect of n-hexane increases proportionally to its partial pressure in the gas phase composition, this effect is more pronounced at the initial steps during the course of polymerization.
In the current thesis study for the first time, the Sanchez-Lacombe EOS as one of the most widely applied thermodynamic models in polymer industry is adapted and developed in order to study not only the solubility but also concentration of ethylene in polyethylene in the absence and presence of an inert condensing agent in order to quantify the speculated cosorption phenomenon under the reactive polymerization condition. By incorporating this thermodynamic model to describe the solubility of ethylene in polymer into a single particle model like Polymer Flow Model (PFM) to estimate the concentration and temperature gradient through a growing polymer particle, it is ultimately attempted to predict the effect of change in the process operating condition by addition of n-hexane as the ICA to the gas phase composition.
Finally in the current thesis study, it is demonstrated how the thermal effect associated with the heat of sorption of ICAs can have a positive effect in terms of avoiding particle over-heating under certain circumstances like its temporary exposition to the defluidized regions inside a fluidized bed reactor (FBR) as a possible undesirable operating condition for this type of reactor set-ups.

abstract: PhD


title: Identification and characterization of E2A-PBX1 genomic binding sites using ChIP-seq and bioinformatics

contributor:
LeBrun, David P.
Pathology and Molecular Medicine

subject:
Bioinformatics
Cancer Biology
Epigenetics
Next-Generation Sequencing
Leukemia
Transcription Factors

abstract: Thesis (Ph.D, Pathology & Molecular Medicine) -- Queen's University, 2014-07-16 12:24:55.279

abstract:
A translocation between chromosomes 1 and 19, referred to as t(1;19), results in expression of the chimeric, oncogenic transcription factor E2A-PBX1 in cases of B-progenitor acute lymphoblastic leukemia. Previous studies have shown that E2A-PBX1 functions as an activator of target gene transcription and that oncogenesis requires direct binding of E2A-PBX1 with the histone acetyltransferase CBP/p300. However, the transcriptional targets of this complex remain largely unknown.  To identify and characterize genomic sites bound by E2A-PBX1 we performed RNA-seq and ChIP-seq for E2A-PBX1, p300 and the functional histone marks H3K4me1, H3K4me3, and H3K27me3 in the t(1;19) leukemic cell line RCH-ACV. Putative E2A-PBX1 binding sites were validated by site-specific ChIP-qPCR. Bioinformatics tools were used to perform “integrative analysis” and characterize E2A-PBX1 binding on a genome-wide scale.
This analysis resulted in the identification of 555 high-confidence E2A-PBX1 sites in the RCH-ACV genome most of which occur distally (>10kb) relative to the TSSs of known genes. Ontology and pathway analysis showed that candidate E2A-PBX1 target genes are involved in hematopoiesis, lymphopoiesis, and cancer progression. Binding of E2A-PBX1 to a random sampling of these sites was performed using site-specific ChIP-qPCR. Consistent with earlier results, E2A-PBX1-bound sites were strongly associated with p300 recruitment and the activating chromatin marks H3K4me1 and H3K4me3; analysis of RNA-seq data confirmed a strong association between proximate binding by E2A-PBX1 and gene transcription. Surprisingly, rather than associating with consensus PBX1 binding sequences as expected, E2A-PBX1 associated with sites bound by the B-lymphopoietic transcription factors EBF1 and wild-type E2A; EBF1, E2A and E2A-PBX1 were confirmed to co-localize at selected E2A-PBX1 binding sites.  The results of this study identify hundreds of E2A-PBX1 genomic binding sites, confirm CBP/p300 recruitment and transcriptional activation in association with these sites, and raise the novel and surprising possibility that E2A-PBX1 disrupts the transcriptional regulation of B-lymphopoiesis through physically associating with the lymphopoietic transcription factors EBF1 and wild-type E2A.

abstract: At the time of submission, the entirety of the information in this thesis remains unpublished.  The goal is to publish the data shortly after thesis submission and release the restriction immediately afterwards.

abstract: PhD


title: Integration of Extremum Seeking and Model Predictive Control for Discrete Time Systems

contributor:
Guay, Martin
Chemical Engineering

subject:
MPC
Real Time Optimization
Vapour Compression System
ESC
Compressor Discharge Temperature
VCS
Extremum Seeking Control
Time-Varying Extremum Seeking Control
Discrete-Time
Model Predictive Control

abstract: Thesis (Master, Chemical Engineering) -- Queen's University, 2014-07-16 13:42:57.628

abstract: This thesis considers a time-varying extremum seeking control algorithm that adjusts set-points provided to a model predictive controller for a vapour compression system. While perturbation-based extremum seeking methods have been known for some time, they suffer from slow convergence rates---a problem emphasized in application by the long time constants associated with thermal systems. The proposed method uses time-varying extremum seeking, which has faster and more reliable convergence properties for this application. In particular, we regulate the compressor discharge temperature using a model predictive controller with set-points selected from a model-free time-varying extremum seeking algorithm. We show that the relationship between compressor discharge temperature and power consumption is convex (a requirement for this class of real-time optimization), and use discrete-time extremum seeking control to drive these set-points to values that minimize power. The results are compared to the traditional perturbation-based extremum seeking approach. Further, because the required cooling capacity (and therefore compressor speed) is a function of measured and unmeasured disturbances, the optimal compressor discharge temperature set-point must vary according to these conditions. We show that the energy optimal discharge temperature is tracked with the time-varying extremum seeking algorithm in the presence of disturbances.

abstract: M.A.Sc.


title: Housing and Banking over the Business Cycle

contributor:
Lloyd-Ellis, Huw
Economics

subject: Economics Banking Housing Macroeconomics

abstract: Thesis (Ph.D, Economics) -- Queen's University, 2014-07-18 15:20:01.603

abstract: In this dissertation, I develop and study a dynamic general equilibrium (DSGE) model with housing and banking. The framework is used to explore several sets of issues related to housing and financial markets. In Chapter 2, I investigate the extent to which a disruption in banks' balance sheets affects the behavior of the housing market and the macroeconomy in an experiment that mimics the Great Recession. The model can qualitatively capture key features of the phenomenon of the Great Recession in response to a financial shock. In Chapter 3, I investigate the model's ability to more generally account for important features of the business cycle observed in the data. In particular, the model with estimated shocks replicates well several key features of housing and financial markets and the macroeconomy observed in the data. It can quantitatively account for the volatility and procyclicality of consumption, investment, house prices and some financial variables. It can also reproduce the co-movements among the quantities of interest. Moreover, I find that technology shocks are the main driving forces of fluctuations in the housing market and the macroeconomy, explaining more than 95 percent of the volatility in housing investment and house prices, and more than 85 percent of the volatility in consumption and GDP. Financial shocks and housing technology shocks are the primary driving forces of fluctuations in the financial market at business cycle frequencies, explaining more than 90 percent of the volatility in loans and net worth. In Chapter 4, I evaluate various macroprudential policies that might help to mitigate the volatility of house prices and household debts, both of which are perceived to be reliable indicators of financial distress historically. My simulation results show that countercyclical policies specifically designed to react to credit and house price growth are useful in stabilizing the financial and housing markets. Moreover, an asymmetric tax schedule that favours impatient households can reduce the volatility of both house prices and household debts without causing excess volatility in other macroeconomic variables. In this regard, this macroprudential policy can be viewed as an effective tool that can successfully contain both financial imbalances and housing market instability in a booming economy exhibiting rapid house price appreciation and credit expansion.

abstract: PhD


title: Characterization and Modulation of Electrical Coupling Between Molluscan Neuroendocrine Cells

contributor:
Magoski, Neil S.
Physiology

subject:
Junctional Current
Afterdischarge
Neuroendocrine Cell
Gap Junction

abstract: Thesis (Master, Physiology) -- Queen's University, 2014-07-22 15:04:28.154

abstract:
The bag cell neurons of Aplysia initiate reproductive behaviour by secreting egg-laying hormone during a prolonged period of synchronous and repetitive firing known as the afterdischarge. Electrical coupling facilitate the functional syncytium between bag cell neurons. We used dual tight-seal whole-cell recording to examine the biophysical properties and modulation of electrical synapses between pairs of cultured bag cell neurons. Transjunctional voltage did not influence junctional conductance. Presynaptically evoked action potentials transferred through gap junctions to elicit postsynaptic electrotonic potentials (ETPs). Bag cell neurons did not show dye coupling; hence, the permeability of electrical synapses was tested using block of K+ current. Presynaptic neurons were whole-cell loaded with Cs+ or TEA and transfer measured by suppression of postsynaptic K+ current. Cs+, but not TEA, reduced the K+ current in electrically-coupled neighbours. In addition, the gap junction blockers meclofenamic acid, niflumic acid, and nitrobenzoic acid, but not glycyrrhetinic acid and quinine, considerably attenuated junctional current.
The afterdischarge is accompanied by an increase in intracellular Ca2+ and upregulation of PKC. Elevating Ca2+ with a train of voltage steps, which mimics the onset of the afterdischarge, decreased junctional conductance. The inhibition was most effective when Ca2+ entry occurred in both electrically-coupled neurons. Depletion of Ca2+ from the mitochondria, but not the endoplasmic reticulum, also attenuated junctional communication. Buffering Ca2+ with high intracellular EGTA prevented uncoupling, as did inhibition of CaM kinase. Application of a PKC activator modestly decreased junctional current, while elevating Ca2+ along with PKC inhibited electrical synapses to an even greater extent than Ca2+ alone. Our results suggest that PKC and Ca2+-dependent activation of CaM kinase inhibit electrical signalling. This may contribute to an enhancement of neuronal excitability leading to the secretion of reproductive hormone. Ca2+ influx also decreased the amplitude and time course of the ETP, which may improve synchrony by preventing lengthy ETPs and out-of-phase postsynaptic action potentials. Thus, modulation of electrical coupling may act as a means to enhance and sustain the release of reproductive hormone.

abstract: M.Sc.


title: Object Class Recognition using Global Shape Descriptors in 3D

contributor:
Greenspan, Michael A.
Electrical and Computer Engineering

subject:
Image Processing
Shape Descriptor
Class Recognition
Global Shape Descriptor
Object Recognition
Computer Vision
Urban Scenes
3D

abstract: Thesis (Master, Electrical & Computer Engineering) -- Queen's University, 2014-07-21 16:07:24.859

abstract: We formulate Global Shape Descriptors for object classifi cation in range data. The goal of object class recognition is to identify and localize objects of interest in a 3D point cloud.This work focuses on the automatic classifi cation of objects that lie within the vicinity of streets in 3D point clouds of urban environments. The system first successfully segments objects of interest from the scene through a combination of ground segmentation and road extraction using a Kalman  filtering approach, and cluster extraction using a region growing technique. Those clusters that fall close to the road are then passed to a classification phase, where they are compared against a labelled database of such clusters. The comparison of clusters is based upon Variable-Dimensional Global Shape Descriptors, which encode the geometry of the objects into multi-dimensional histograms, the similarities of which are measured against the database clusters using a variety of metrics including Earth Movers Distance and Bhattacharya similarity. The technique was tested on a dense data set acquired from central New York City, containing 110 objects partitioned into 5 classes. The method had an average successful recognition rate of 94.5% for a rich set of vehicles, pedestrians, and street furniture such as  re hydrants, street signs, and poles.

abstract: M.A.Sc.


title: Analysis of Potentially Toxic Bioaccessible Elements in Locally Available Bread Using Continuous On-Line Leaching Coupled to Inductively Coupled Plasma Mass Spectrometry

contributor:
Beauchemin, Diane
Chemistry

subject: Bioaccessibility

subject: Bread

subject: Collision Reaction Interface (CRI)

subject: On-Line Leaching

abstract: Thesis (Master, Chemistry) -- Queen's University, 2014-07-22 11:14:27.722

abstract: A previously developed, efficient and simple on-line leaching method was used to assess the bioaccessible fraction of potentially toxic elements (Cr, As, Pb and Cd) in whole wheat brown and white bread samples. Artificial saliva, gastric juice and intestinal juice were successively pumped into a mini-column, packed with bread (maintained at 37°C) connected on-line to the nebulizer of an inductively coupled plasma mass spectrometry (ICP-MS) instrument equipped with a collision-reaction interface (CRI) to mitigate the impact of polyatomic interferences. In contrast to the conventional batch method to which it was compared, this approach provides real-time monitoring of potentially toxic elements that are continuously leached with 3 artificial gastro-intestinal reagents. Mass balance for both methods was verified at the 95% confidence level. Results obtained from the whole wheat brown and white bread showed that the majority of Cr, Pb and Cd was leached by gastric juice but, in contrast, the majority of As was leached by saliva. Results showed a higher total content for elements in whole wheat bread than in white bread but in contrast, there was a higher percentage of bioaccessible elements in white bread than in whole wheat bread. This difference may be attributed to the several food processing steps involved for white bread compared to whole wheat bread. Both the on-line and batch methods showed that 40% -98% of toxic elements in bread samples are bioaccessible. Hydrogen as the CRI gas was efficient at minimizing carbon- and chlorine-based polyatomic interferences.

abstract: M.Sc.


title: Later-Life Filipino Immigrants in the Greater Toronto Area:  A Case Study of Health Status and Utilization of Services

contributor:
Rosenberg, Mark W.
Geography

subject:
Health Determinants
Aging
Health and Social Services
Immigration
Filipino immigrants

abstract: Thesis (Ph.D, Geography) -- Queen's University, 2014-07-22 15:48:39.231

abstract: This research contributes to the growing field of ethnogerontological research in Canada offering insights into the health and aging experiences of immigrants, with specific reference to the Filipino immigrant community.  The two-fold purpose of this study was to first examine how ethnicity and immigration operate within various settings of senior-centered community and health care services. Secondly, this study examined the role of place and how it shapes health and age identities among later-life Filipino immigrants. In total 37 semi-structured interviews (22 key informants and 15 later-life Filipinos) and a survey of 138 questionnaires were collected for analysis. Results from key informant interviews support current literature which suggests that immigrant seniors experience significant barriers to services, such as language, economic difficulties, immigrant family conflict and social and cultural isolation. Sharing from their working and personal experiences, key informants expanded on their own views about cultural and ethnic diversity describing the intersectionality of immigrant, ethnic and social identities, as well as their experiences of health and aging in Canada. They also discussed the predominance of monocultural views of aging and the limitations of multicultural and culturally competent senior care services. Compared to research on other Canadian immigrant populations, later-life Filipinos reported high levels of physical and mental health and described very few barriers to health care access in Canada. In-depth analyses of later-life Filipinos’ narratives on their aging and migration experiences revealed culturally-informed views, expectations and understandings of what it means to age in a foreign land. Older Filipinos shared their ideas on the meaning of place, perceptions of aging and age identity, such as place-making and a sense of belonging in older age. This research considers the significance of ethnicity and migration as important social determinants of health and advocates for more life-course analyses on the health and aging experiences of the older immigrant. This research was built from a conceptual framework that incorporated concepts from life course theory and social determinants of health approaches in providing a critical perspective and examination about the role of place, culture and migration on normative views of the aging experience.

abstract: PhD