title: The Gemorphology of the Bonnechere Caves

contributor:
Ford, D.C.
Geography

abstract: Title: The Geomorphology of the Bonnechere Caves, Author: John A. Marshall, Location: Thode

abstract:
This paper deals with the specific problem of the formation ot the Bonnechere Caves, and the more universal problem of scallop or flute formation. The Bonnechere Caves have been studied in two previous papers, which speculate on their formation, but no detailed field work has been done that deals with all the significant variables that affected their formation. The problem of scallop formation has remained unexplained in its entirety, and there have been no large bodies of data collected to analyse the effects of different variables on their development. The purpose of this paper was to study these two problems through detailed field work and to arrive at some concrete conclusions concerning cave formation and scallop formation which could be substantiated by
significant data. Because of the uniqueness of each cave system, it is very difficult to make any generalizations about all cave systems from the observations of one single system -- except those generalizations which border on intuition. However, a solution or partial solution for the scallop problem would have much wider applications because this feature is common to practically all caves and deals with the basic mechanics of flow. The purpose is not to explain the actual physics of scallop formation which the author is not equipped to do, but rather to discover correlations between the size of scallops and the variables involved in their formation and then use the scallop size as an index of these variables. In this way the problem is a geographical one since the main concern is to apply correlations over space. The author's background prevent detailed discussion of the many properties of variables involved in the development of caves. However, since the process of cave development is the primary issue, the role of the variables in the development of the cave is the main concern rather than the intrinsic nature of the variable itself. Only that degree of detail which leads to an understanding of the role of each variable in the whole framework is necessary in any geographical study.

abstract: Thesis

abstract: Bachelor of Arts (BA)


title: Sustainability in Supply Chains: Models and Metrics

contributor:
Hassini, Elkafi
Business

subject:
Sustainability
Supply Chain Management
Game Theory
Performance Measurement

abstract: In this dissertation, we study several quantitative approaches centered on supply chain management, sustainability development, performance measurement frameworks, and environmental regulation mechanisms. The topic of sustainability has been of great interest for the past few years in academia. Many governments also have taken actions to incentivize firms to reduce their negative environmental and social impacts. It is unclear, however, how successful policy makers have been in reducing the sustainability threats. This raises the question of ``how can policy makers play an effective role in helping businesses become more sustainable, while complying with entrepreneurs and investors' expectations?'' This dissertation is organized on the basis of six chapters. Having reviewed the literature and research directions of sustainable supply chain management in Chapter 1, we present a review of sustainability performance measurement frameworks in Chapter 2. In addition to proposing a framework to assess sustainability efficiency in supply chains, we discuss research questions with a focus on the social aspect of sustainability development. In Chapter 3, we develop a two-stage data envelopment analysis model with an application to the energy sector. This approach measures relative efficiencies of a number of comparable decision makers and does not require predetermined weights of indicators. We relax some restricting assumptions used in previous studies and obtain a nonlinear problem, for which we develop a solution method. Chapter 4 investigates a more general multi-stage assessment framework that monitors suppliers, manufacturers, distributers, and retailers' sustainable practices. The major finding is developing a multi-stage data envelopment analysis to measure supply chains' sustainability efficiency. In Chapter 5, we investigate market-based schemes with a focus on curbing pollution emitted by business entities and develop a game-theoretic formulation. Finally, we summarize the major contributions of this dissertation and future research directions in Chapter 6.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: The Crystal Structures of Some Ternary Oxides and Fluorides

contributor:
Brown, I. D.
Chemistry

subject: crystal, structures, ternary, oxides, fluorides, atoms

abstract:
 The crystal structures of five ternary oxides and fluorides have been determined. It is shown that the gross features of these structures and the coordination of the atoms can be described in terms of the theory of close-packing of spheres. However, in each of the structures there appear cations whose coordination cannot be uniquely predicted, as the cation-anion radius ratios are close to the critical value for transition from one coordination to
another.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: A Palaeoecological Investigation of the Treeline Zone North of Yellowknife, NWT

contributor:
MacDonald, G. M.
Geography

subject: palaeoecological, investigation, Treeline, zone, Yellowknife, NWT, pollen, charcoal, sediment, forest vegetation, Picea mariana

abstract:
 The pollen, charcoal and sediment stratigraphies of two cores from small lakes located northeast of Yellowknife, NWT are examined. The focus of this study is to reconstruct post-glacial vegetation changes in this climatically sensitive area. The resulting vegetation history is compared to similar reconstructions from across Canada. The pollen content of twenty-eight modern sediment samples, collected from the forest, the forest-tundra and the tundra zones were used to aid in the interpretation of the fossil record. Radiocarbon dates indicate that the fossil records from these lakes span ~7 500 years. The initial vegetation, shrub Betula tundra, was established at ~7 000 BP and persisted until ~6 000 BP. The presence of Ericaceae, Myrica, and Sphagnum distinguishes this zone from similar zones from western Canada and suggests the existance of large areas of bog environment. This zone is succeeded by a second shrub tundra zone, which is marked by a dramatic increase in Alnus crispa and Alnus incana. This zone spans from ~6 000 BP until ~5 000 BP. A synchronous increase in Alnus is noted from sites across Canada and is attributed to an increase in moisture. The third zone, spanning from ~5 000 BP to ~3 500 · BP, delimits the existance of forest vegetation defined by the northward expansion of Picea mariana. The delay of Picea mariana expansion into the area relative to its arrival in western Canada can be explained by one of the following: 1) geological differences; or 2) remnant glacial ice retarding climatic amelioration; or 3) the long-wave westerly disturbance, which causes cooler temperatures in the east when warmer
temperatures persist in western Canada; or 4) some combination of the above. The decline of forest vegetation at ~3 500 BP marks the establishment of modern tundra vegetation at both
sites. Climatic cooling coupled with fire caused the extinction of aboreal vegetation at the study sites.

abstract: Thesis

abstract: Master of Science (MSc)


title: A Study of the Low-Lying Excited Levels in the Even Lead Isotopes

contributor:
Preston, M. A.
Physics

subject: low-lying, excited, levels, even lead, isotopes, nuclear

abstract:
 In recent years, a number of qualitative calculations of various nuclear properties have been undertaken based on a "pairing-plus-quadrupole" force model. The present work involves an extension of the techniques associated with this model and is an investigation of the extent to which it can quantitatively predict properties of the low-lying levels of spherical even-even nuclei.

 As a particular application, the energies of several of the low-lying levels and the reduced transition probabilities for the first 2+ levels are calculated for the even isotopes
of lead.

 These calculations show in a natural way how collective levels arise, and help to clarify the nature both of these and of the non-collective levels.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: The Improved Quasistatic Method Applied to Thermal Reactor Kinetics

contributor:
Trojan, O. A.
Engineering Physics

subject: quasistatic, thermal, reactor, kinetics, three-dimensional, CANDU-PHW

abstract: In this report, the theory for the Improved Quasistatic (IQS) method of solving the three-dimensional, two-neutron-energy group, time-dependent neutron diffusion equations is developed, and approximations appropriate to the CANDU-PHW reactor system are introduced. The theory is extended to a numerical formulation of the problem. The TM-2 computer program (written in FORTRAN 5), which employs the IQS method to numerically solve a two-dimensional form of the diffusion equations (with a correction to account for axial leakage), is outlined. Input and output descriptions for the TM-2 code are provided.

abstract: Thesis

abstract: Master of Engineering (MEngr)


title: Optimum System Modelling Using Recent Gradient Methods

contributor:
Sinha, N. K.
Bandler, J. W.
Electrical Engineering

subject: optimum, system, modelling, recent gradient methods, Fletcher-Powell, algorithms

abstract:
 A study of gradient optimization techniques, in particular as applied to system modelling problems, is made. Three efficient techniques are used to derive optimum second-order and third-order models for a seventh-order system. The optimization techniques are the Fletcher-Powell method, a more recent method proposed by Fletcher and a method based on a more general objective function proposed by Jacobson and Oksman.

 The approximation is carried out in the time domain. Least squares and least pth criteria are used, and almost minimax results are obtained for large values of p. Values of p up to 10^12 are successfully used. The results are compared with other minimax type algorithms.

abstract: Thesis

abstract: Master of Engineering (MEngr)


title: Uranium(VI), Thorium(IV) and Scandium(III) Complexes of Tropolone

contributor:
Corsini, A.
Chemistry

subject: uranium, thorium, scandium, complexes, tropolone, solvates, ligand, molecule

abstract:
 New complexes formed between U(VI), Th(IV) and Sc(III) and tropolone have been prepared. These include the solvates UO2T2⋅X and ThT4⋅X (T = the tropolone anion; X =H2O and CH3OH), and the unsolvated chelate Sc3⋅. Some U(VI), Th(IV) and Sc(III)
tropolonates reported in the literature have been re-examined and found to be incorrectly formulated.

 The adduct chelates UO2T2⋅HT, ScT3⋅HT and the previously unreported
ThT4⋅HT have been prepared. Evidence has been presented for hydrogen-bonding in the additional monodentate tropolone ligand.

 The thermal conversion of the above solvates and adducts to yield UO2T2, ThT4 and ScT3 has been described.

 The ability of tropolone and other bidentate ligands to displace the water molecule in UO2T2⋅H2O and ThT4⋅H2O, and the addition of such ligands to ScT3, has been studied.

abstract: Thesis

abstract: Master of Science (MSc)


title: Optimal Detection and Estimation for Echo Ranging in a Randomly Fading Environment

contributor:
Sinha, N. K.
Electrical Engineering

subject: optimal, detection, estimation, echo, fading, environment, a posteriori,  binary

abstract:
 A self-synchronized echo ranging system with optimum utilization of signal estimation and detection strategies has been designed and simulated. A binary convolution code has been utilized to modulate the transmitter signal. The random medium is modelled by a vector sum of a fixed and a random component; the medium fading process has a Rician distribution density. A channel estimator has been derived using a maximum a posteriori probability criterion. The estimator is an adaptive processor whereby the variance of the medium fading process is recomputed during each updating cycle. The estimator attempts to provide a coherent input to the correlator. An optimum processor for the signalling described is an ordered serial estimator-correlator combination. It is conjectured that the estimator offers an
improvement in signal processing gain of approximately 5 dB over and above the non-optimized system. Accompanying this is an improvement in peak-to -sidelobe ratio and in false alarm probability. A 3 bit (8 level) quantized system is conjectured to be a 'good' trade-off between degradation in system performance and simplification in system implementation.

abstract: Thesis

abstract: Master of Engineering (MEngr)


title: FACTORS INFLUENCING AIR QUALITY HEALTH INDEX ADOPTION BY THE AT RISK POPULATION IN HAMILTON, CANADA

contributor:
Newbold, K. Bruce
Eyles, John
Williams, Allison
Earth and Environmental Sciences

subject:
public health
air pollution
environmental risk perceptions
health behaviour
Socioeconomic Status
Air Quality Health Index

abstract: The Air Quality Health Index (AQHI) is a 10-point scale that communicates the cumulative health risks associated with air pollution (ECCC, 2016). The general theme of this dissertation centers on an understanding of AQHI adoption while accounting for socioeconomic status (SES) in order to facilitate AQHI uptake by the public with particular focus on “at risk” populations (i.e. young children, seniors, and those with pre-existing respiratory and/or cardiovascular conditions).   The study is unique since it approaches AQHI adoption consistent with the ecological model and an equity lens, and AQHI adoption is considered at the individual, organizational and community levels.  The study area for this dissertation is Hamilton, Ontario, Canada.  The findings from this dissertation contribute to an understanding of why AQHI is or is not being adopted and suggests potential intervention strategies to increase its uptake.  Consistent with health behaviour theory, demographics (gender, age, education, area of residence), knowledge/understanding and individual risk perceptions (neighbourhood air effects on health) were found to be significant predictors of AQHI adoption. Additionally, perceived benefits of AQHI adoption included protection of health for self and those cared for via familial and/or occupational duties. While perceived barriers of AQHI adoption included lack of time required to check and follow AQHI health messages and the inability to “self-identify” as belonging to the “at risk” population.   This dissertation proposes that increases in AQHI adoption may be achieved by increasing AQHI knowledge and emphasizing the benefits and relevance of AQHI such that “at risk” populations can self-identify.  Additionally, AQHI uptake may be increased by providing AQHI information at a neighbourhood scale via local media sources and wearable devices.

abstract: Dissertation

abstract: Doctor of Philosophy (PhD)


contributor:
Serdula, K.J.
Engineering Physics

abstract: Title: The Spacial Modes of Three-Region Partially Reflected Cylindrical Two Energy Mode Thermal Reactor, Thin Films and Ion Implantation, Author Madat Mamourian, Location: Thode

abstract:
The purpose of this study is to determine analytically
the spatial modes and their adjoints for a three region partially
reflected, CANDU-BLH type core, using modal expansion techniques.

abstract: Thesis

abstract: Master of Engineering (ME)


contributor:
Embury, J.D.
Metallurgy

abstract: Title: The Effect in Strain Path on Mechanical Behaviour of an Al-Cu Alloy, Author: Nicole D.W. Martin, Location: Thode

abstract:
The primary objective of the present study was to
examine the effect of a 90° change in strain path, on the
mechanical behaviour of an alloy, and its relation to the
microstructure. In order to achieve this, the mechanical
behaviour in uniaxial tension and compression of three different
heat treatments of an Al 3.6 wt% Cu alloy and of pure
aluminum were investigated. The heat treatments include a
solid solution, a peak aged and an averaged condition. The
results show a large 'Bauschinger' type effect in the overaged
Al-Cu after 15% pre strain.

The differences in mechanical behaviour in the materials
studied were rationalized with the aid of transmission
electron microscopy observations, and work hardening models
from the literature. A simple model which relates the work
hardening behaviour to a measurable microstructural feature
via the initial obstacle spacing, is presented and compared
with the experimental data.

The fracture behaviour of each of the materials was
also observed. The results are documented in a generalized
form of a plane stress map, and discussed in terms of the
movement of the material as yield surface in stress space as
it work hardens. The potential use of this type of map for representing ductile fracture processes as well as intergranular
surfaces ( for a wide range of stress states ) is discussed.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Hamed, M.S.
Mechanical Engineering

abstract: Title: Study of Wetting Phenomenon During Cooling of Curved Surfaces Using Impinging Water Jets, Author: Muhammad Akmal, Location: Thode

abstract:
Wetting phenomenon during cooling of hot cylindrical specimens using Impinging Jet
of water has been studied. Effect of jet velocity, jet diameter, water temperature,
specimen surface temperature and surface curvature on propagation of wetting front has
been analyzed. Propagation of wetting front correlated well with power function of time.
Experiments were conducted at specimen surface temperatures of 250, 500 and 800°C.
Water temperatures of 20, 50 and 70 or 75 or 80°C were employed with Jet velocities of
5 and 7.75m/sec. Jet diameters of 3mm and 4mm were utilized during experiments.
Propagation of wetting front strongly depends upon water temperature. Wetting front
grows faster at low water temperature and high jet velocities. For constant water
temperature, growth of wetting front is high with high jet velocities. Velocity of wetting
front increases with jet diameter of 4mm when compared with that of 3mm due to
increase in mass flow. The influence of jet diameter is greater for low water temperature,
low surface temperature and high jet velocities. Effect of jet velocity and degree of subcooling
on constant "a" and exponent "n" of the power relation are studied. Constant "a"
is found to be linear function of jet velocity and degree of sub-cooling. Exponent "n"
appears to be independent of jet velocity but weekly dependent on degree of sub-cooling.

Propagation of wetting front with time was analyzed in comparison with the
transient temperature drop of material for different thermocouples embedded at stream
wise locations within specimen at a distance of 1mm from surface. Temperature readings
were used to predict the propagation of wetting front, which was found to be valid for a
distance of 10mm from impingement point.

Effect of surface curvature was analyzed by comparing the results of present
study with those reported by previous researchers. Surface curvature was found to have
significant impact on propagation of wetting front.

abstract: Thesis

abstract: Master of Applied Science (MASc)


title: Transport in Dilute Alloys

contributor:
Carbotte, J.P.
Physics

abstract: Title: Transport in Dilute Alloys, Author: John A. Mason, Location: Thode

abstract:
In essence this work is a study of transport
properties of dilute alkali alloy systems and the
numerical methods used to study them. The first chapter
deals with the theory of lattice dynamics and the methods,
based on this theory, of calculating phonon frequency
distributions. These distributions are subsequently used
to determine properties of alkali alloy systems.

Chapter II examines the use of the Ashcroft
pseudopotential. Different types of screening are
considered and the effects of adding many body corrections
are examined.

A study of alkali alloy systems is undertaken in
the third part of the work. Impurity theory is considered
and calculations are undertaken for several alkali dilute
alloy systems. Finally the results of the impurity
calculations are examined for deviations from Matthiesen's
rule.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Masterson, J.S.
Computation

abstract: Title: An Interactive Dialogue for the Creation, Maintenance and Querying of a Data Base Representative of the Anatomy of an Administrative System, Author: Pratima Mathur, Location: Thode

abstract:
The logical structure of a database is given, and is
representative of the anatomy of an administrative system,
and of the personnel organization by which it is operated.
This project will adopt an appropriate host computer,
terminal, and physical representation of the database, for
the main purpose of developing a user-terminal dialogue by
which the database can be created and maintained. The
dialogue should be as easy and flexible to use by an audit
analyst as is possible, while at the same time imposing a
systematic and disciplined approach to the task.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Wade, J.H.T.
Mechanical Engineering

abstract: Title: The Two-Dimensional Development and Analysis of Blade Profiles Having Larger Turning Angles, Author: Ramesh K. Malhotra, Location: Thode

abstract:
The advances in gas turbine technoloqy in recent years
has focussed attention on problems associated with the attainment of
high work output. This led to the consideration of high work output
per blade, and thereby to the consideration of designing the blades
with large turning angles. The blade's profile, pressure distribution, pressure gradients and
velocity triangles are drawn for each set of blades. The theoretical performance
of the blades has been examined over a range of incidence angles
from zero to nine degrees.

abstract: Thesis

abstract: Master of Engineering (ME)


contributor:
King, G.W.
Chemistry

abstract: Title: Calculation of the Electronic States of the Linear Methylene (CH2) Radiacal by the LCAO/ASMO/CI Method, Author: Gulzari L Malli, Location: Thode

abstract: The electronic energy levels of the linear CH2 radical are calculated by the LCAO/ASMA/CI method and it is definitely established that 3Σg is the ground state. Various electronic transitions are predicted as being spectroscopically accessible. Possible electronic states involved in the spectral transitions observed so far for CH2 are also suggested. The role of the "Configuration Interaction" and the effect of including doubly excited configurations in calculation energy levels by the Molecular Orbital method are discussed.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Crocket, J.H.T.
Geology

abstract: Title: The Concentration and Distribution of Gold in the Uraniferous Conglomerates of Elliot Lake, Author: Robert D. Martindale, Location: Thode

abstract:
<p>A neutron activation procedure for the determination
of Au in sulfides has been utilized to examine the concentration
and distribution of Au in pyrite, and, to a lesser extent, in chalcopyrite
of the conglomeratic uranium ore of the Denison Mine, Elliot Lake,
Ontario. An extensive literature review of the geology of the Elliot
Lake area is presented together with brief surveys of the geologies
of two analogous areas, the Witwatersrand of South Africa, and the
Jacobina of Brazil. A discussion of the two leading theories regarding
the origin of such deposits follows. The present state of knowledge
concerning the nature and causes of the distribution of Au in both
rocks and sulfides is discussed. Analytical results are presented for
Au in 58 pyrite, 8 quartz, and 2 chalcopyrite samples, and for Ir in
4 pyrite samples, all from the Denison Mine ore zones. These results
are discussed with respect to their implications concerning the
origin of the ore and of auriferous and/or uraniferous quartz pebble
conglomerates in general.<p>

abstract: Thesis

abstract: Master of Science (MS)


title: Adaptive Signal Processing for Digital Communication Over Dispersive Unknown Channels

contributor:
Haykim, S. S.
Electrical Engineering

subject: adaptive, signal, digital, communication, dispersive, unknown channels, pulses

abstract:
 The problem of communication would have been trivial if the channel through which the signal must propagate were ideal, that is, an all pass system with a linear phase response. In practice, channels are non-ideal; imperfections in the physical channel, such as time-dispersion and frequency-dispersion, are the results of signal dependent distortions. In addition, upon reception the signal is further corrupted by the inevitable presence of additive random noise. Time dispersion causes successive pulses to overlap, thereby creating a phenomenon which has been termed 'intersymbol interference'. Frequency dispersion causes the received signal spectrum to vary both in amplitude and phase. Unless these channel imperfections are taken into account in the design of the communication system, the rate of data transmission can be limited by the physical channel. Also, the presence of additive noise poses further limitations on the ultimate performance of the system.

 This thesis is concerned with adaptive signal processing techniques for digital communication through dispersive unknown channels. The research undertaken has been principally aimed at the analytical derivations of an adaptive recursive filter and an adaptive recursive equalizer, and the simulations of overall binary communication systems, taking into account dispersive effects as well as random noise.

 Computer simulation tests have indicated that the new adaptive equalizer exhibits a much more robust operation capability and improved system performance than the conventional adaptive equalizer. This study has indicated that adaptive signal processing is a viable technique upon which a reliable communications system may be designed.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Suffering in the Face of Death: The Social Context of the Epistle to the Hebrews

contributor:
Westfall, Cynthia Long
Porter, Stanley E.
Christian Theology

subject: suffering, face of death, social context, epistle, Hebrews

abstract: The topics of suffering and death appear throughout the Epistle to the Hebrews but have rarely been examined in New Testament scholarship. This study offers a thorough investigation of each reference to these topics in the epistle using semantic domain analysis. Incorporating the work of linguist M.A.K. Halliday, it then attempts to connect these topics to the social situation addressed by the author of Hebrews. It is determined that the author is responding to the reality of suffering in the lives of his audience. This is closely connected to a perceived threat or fear of death on the part of the probable recipients. With this social context in place, this study examines how the author responds to this situation by creating models of endurance in suffering and death. The author establishes these exemplars in order to motivate his audience toward similar endurance within their own social context.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: MODELLING THE SPREAD OF INFECTIOUS DISEASES

contributor:
Dushoff, Jonathan
Earn, David
Computational Engineering and Science

subject:
epidemiology
mathematical model
HIV
syphilis

abstract:
Mathematical models applied to epidemiology are useful tools that help understand how infectious diseases spread in populations, and hence support public-health decisions. Over the last 250 years, these modelling tools have have developed at an increasing rate, both on the theoretical and computational sides.
This thesis explores various modelling techniques to address debated or unanswered questions about the transmission dynamics of infectious diseases, in particular sexually transmitted ones.
The role of sero-discordant couples (when only one partner is infected) in the HIV epidemic in Sub-Saharan Africa is controversial. Their importance compared to other sexual transmission routes is critical when designing intervention policies. In chapter 2, I used a compartmental model with an original partnership process to show that infection of uncoupled individuals is usually the predominant route, while transmission within discordant couples is also important, but to a lesser extent.
Despite the availability of inexpensive antimicrobial treatment, syphilis remains prevalent worldwide, affecting millions of individuals. Development of a syphilis vaccine would be a potentially promising step towards control, but the value of dedicating resources to vaccine development should be evaluated in the context of the anticipated benefits. In chapter 3, I explored the potential impact of a hypothetical syphilis vaccine on morbidity from both syphilis and HIV using an agent-based model. My results suggest that an efficacious vaccine has the potential to sharply reduce syphilis under a wide range of scenarios, while expanded treatment interventions are likely to be substantially less effective.
General concepts in epidemic modelling, that could be applied to any disease, are still debated. In particular, a rigorous definition and analysis of the generation interval – the interval between the time that an individual is infected by an infector and the time this infector was infected – needed clarification. Indeed, the generation interval is a fundamental quantity when modelling and forecasting epidemics. Chapter 4 clarifies its theoretical framework, explains how its distribution changes as an epidemic progresses and discuss how empirical generation-interval data can be used to correctly inform mathematical models.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: EXTERNAL CEPHALIC VERSION BEFORE TERM AND THE RISK OF PRETERM BIRTH

contributor: Clinical Epidemiology/Clinical Epidemiology & Biostatistics

abstract:
Background: External cephalic version (ECV) is an obstetric maneuver used to turn a fetus from breech (buttocks first) to cephalic (head first) presentation. A Cochrane Review suggests that beginning ECV earlier in pregnancy (before 37 weeks) compared to later in pregnancy (37 weeks onwards) is associated with a decreased likelihood of breech presentation and cesarean section; however, it appears to be associated with an increase in late preterm birth (PTB; <37 weeks).

Objective: To explore the association between early ECV and the risk of PTB.

Method: Secondary data analyses of the Early ECV Trials. 1765 women with low-risk breech pregnancies were enrolled with 749 receiving at least one ECV before term. Accounting for centre in our analyses, risk factors for PTB, including exposure to early ECV, were analyzed for their contribution to odds of PTB. Interactions between risk factors and early ECV were explored. Characteristics among women who received an ECV before term and delivered PTB (N=48) were described.

Results: Early ECV exposure was not an independent predictor of PTB; however, the interaction between early ECV and anterior placental location was a significant predictor, and associated with a two-fold increase in the odds of PTB (OR: 2.05; 95% CI: 1.12 – 3.71; p=.02). Compared to other women in the study, women with an ECV before term who delivered PTB (N=48) were more likely to have an anterior placenta (67% vs. 35%), and this proportion was even higher among women who delivered preterm and within 48 hours of early ECV exposure (75%).

Conclusion: Exposure to early ECV was associated with risk of PTB for women with an anterior placenta. The manipulation that occurs during an ECV may induce fetal distress in a preterm fetus and/or increase risk of uteroplacental hemorrhage for those with an anterior placenta. These biological pathways may be triggered and initiate PTB.

abstract: Thesis

abstract: Master of Science (MSc)


title: Mass Extinction of Caribbean Corals at the Oligocene-Miocene Boundary: Paleoecology, Paleoceanography, Paleobiogeography

contributor:
Risk, Michael J.
Geology

subject: extinction, Caribbean corals, Oligocene-miocene, paleoecology, turbidity, reefs, sedimentation

abstract:
 About half the Caribbean hermatypic corals died out at the Oligocene-Miocene boundary, about 25 Ma. Roughly two thirds of those corals which died out in the Caribbean are still extant in the Indo-Pacific. The coral and coral associate faunas of three Upper Oligocene and three Middle Miocene fossil reefs in western Puerto Rico were compared. Corals on these sites suffered 59% generic extinction, and 54% species extinction. Nearly all coral genera which are tolerant of turbidity or turbidity and cold water survived. All corals found exclusively or principally on Oligocene shelf-edge reefs became regionally extinct. There are no shelf-edge reefs documented from the Miocene in the Caribbean.

 Coral associates, the endolithic organisms which live in coral skeletons, were almost completely unaffected by this extinction. Likewise, reef and off-reef gastropods, bivalves, and echinoids suffered only insignificant reductions in diversity. Only corals and large benthic foraminifera were strongly affected by the extinction. It is significant that zooxanthellate organisms were the primary victims of this extinction. There is no evidence to suggest effects at higher trophic levels.

 Paleontological evidence from corals, coral associates, and gastropods suggests enhanced upwelling in the Caribbean during the Miocene and Early Pliocene. This enhanced upwelling could account for the extinction by cooling Caribbean coastal surface waters and restricting reef development to on-shelf patch reefs, where corals would be subject to more intense sedimentation. Paleoceanographic models indicating West to East deep circulation through the Central American Seaway during the Miocene provide a mechanism for this enhanced upwelling.

 Life history characteristics may have influenced survivorship among the corals, but apparently had no effect on coral associates. Corals which brood their larvae survived in greater proportions than corals which broadcast. This pattern is opposite that observed in studies on molluscs and other invertebrates.

 This regional extinction was important in the division of a previously cosmopolitan reef fauna into the modern provincial faunas. Explaining this minor mass extinction may contribute to an understanding of the volatile record of reefs in the larger mass extinctions of the Phanerozoic.

abstract: Thesis

abstract: Master of Science (MSc)


contributor:
Burghardt, A.F.
Geography

abstract: Title: An Analysis of Administrative Areas and Centres Used by Eight Human Service Agencies in Southern Ontario, Author: Bryan H. Massam, Location: Thode

abstract: This thesis describes the spatial arrangement of eight human service agencies for the case of Southern Ontario. Using the location of the administrative centres and the distribution of population, a measure of the compactness of each area is derived. This is the moment of inertia. The administrative centres are relocated within the areas currently used in such a way as to minimize the moment of inertia. This is the optimal location of the centre. By comparing the moment of inertia for the optimal location and moment of inertia for the actual location, an index of efficiency for each administrative unit is calculated. Using four variables a ranking of importance of administrative centres is provided. The approach is essentially quantitative.

abstract: Thesis

abstract: Master of Arts (MA)


contributor:
Johns, M.W.
Chemistry

abstract: Title: Structure of Rubidium and Strontium Nuclides of Mass 90 and 91, Author: James F.A. Mason, Location: Thode

abstract:
The level structures of 90,91Rb and 90,91Sr, as populated in beta decay, have been investigated using Ge(Li) and NaI(Tl) gamma ray and plastic beta ray spectrometers, and standard spectroscopic techniques. Beta-gamma and gamma-gamma coincidence experiments have been used to establish twelve levels in 90Rb, four levels in 91Rb and to determine the ground state Q-values for the decay of
both 90Kr and 91Kr. Thirty-one levels have been proposed in 90Sr and eighteen in 91Sr on the basis of gamma-gamma coincidence experiments only. The lifetime of the first excited state in 91Sr has also been measured.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


contributor:
Huber, D.G.
Mechanical Engineering

abstract: Title: An Evaluation of a Cold Cranking Simulator for Oil Viscosity at Sub-Zero Temperature, Author: Michael G. Malloy, Location: Thode

abstract: An experimental evaluation of the cold cranking simulator at -20°C is reported in this thesis. The evaluation was made on eight special research engine oils, ranging in viscosity grade from SAE 5W to SAE 20W, including multi-grade oils, and seven specially blended 5W30 oils of commercial nature. Repeatability and accuracy were analyzed statistically and correlations were made with other viscosity measurements on the same oils, including an engine cranking evaluation of the oils. The viscosities determined by the cold cranking simulator were found to correlate well with those from the engine cranking tests and a relationship between measured viscosity and engine cranking speed was established.

abstract: Thesis

abstract: Master of Engineering (ME)


contributor:
Thode, H.G.
Mills, R.H.
Macnamara, J.
Chemistry

abstract: Title: The Separation of Isotopes by Thermal Diffusion, Author: J. Gordon Lindsay, Location: Thode

abstract:
The phenomenon of thermal diffusion in gases consists in the fact
that a temperature gradient in a mixture of two gases or isotopic forms
of the same gas gives rise to a concentration gradient of the two gases.
The effect in general is to concentrate the lighter molecule in the hot reservoir and the heavier molecule in the cold reservoir. The phenomenon was predicted by Enskog (1) in 1911 and independently by Chapman (2) in 1917. It was experimentally verified in 1917 by Chapman and Dootson (3). In the case of isotopes the separation was small compared to other separation methods and did not appear to be of any practical use (4). In 1938 Clasius and Dickel (5) developed a method of greatly enhancing the thermal diffusion effect. Their apparatus consisted of a log vertical tube closed at both ends and containing a gas at approximately atmospheric pressure; along the axis of the tube was suspended a platinum wire which could electrically heated to be a high temperature. The lighter molecules being concentrated near the hot wall were carried upward by convection currents, while the heavier molecules were concentrated at the bottom. Equilibrium was established when the thermal siphoning effect is balanced by self diffusion.</p> <p> The separate stable isotopes of carbon, nitrogen, oxygen, and sulphur are of considerable importance in isotope exchange and tracer work. The method of chemical exchange is particularly suited to the production of relatively large quantities of material of medium enrichment. Where high dilution of the tagged material is necessary, or in experiments designed to measure the physical and chemical properties of the enriched isotope, a higher concentration is desirable. Thermal diffusion provides a convenient method for the production of small quantities of highly enriched material. Considerable quantities of sulphur and oxygen enriched in S34 and O18 respectively were produced at McMaster several years ago and it seemed desirable to secure further enrichment of these isotopes by the thermal diffusion method. Thermal diffusion columns set up previously (38) have been testes and used in the separation of the isotopes of nitrogen, oxygen, and sulphur using N2, O2 and SO2 gases respectively. Nitrogen gas was used in the separation of the nitrogen isotope due to its availability and its thermal stability. The simplest gaseous sulphur compound which is thermally stable in the temperature range necessary is SO2. Calculations from viscosity data (7,10) indicate that SO2 would be a particularly poor gas to use. However, since several factors influence the separation  it was decided to try SO2 before discarding the data. In the separation of the oxygen isotopes the starting material was water whose O18 content was 7.5 normal. Of the common gaseous compounds of oxygen: O2, CO and CO2, the gas predicted to give the largest separation is CO with O2 next. Oxygen was used due to its ease of preparation and the fact that its predicted separation is only slightly less than that of CO2.

abstract: Thesis

abstract: Master of Science (MS)


title: NMR Analysis of 5'-5' Phosphodiest Bonded rCUG

contributor:
Bell, R.A.
Chemistry

abstract: Title: NMR Analysis of 5'-5' Phosphodiester Bonded rCUG, Author: Garry W. Buchko, Location: Thode

abstract:
A mixture of two isomers of rCUG was separated by
HPLC, 5'C3'-5'U3'-5'G3' (low Rf) and 3'C5'-5'U3'-5'G3' (high
Rf). These were characterized by proton, carbon-13, and
phosphorus-31 NMR and enzymatic methods. This allowed for
the first detailed analysis of the effect of a 5'-5'
phosphodiester bond upon the solution structure of a
ribo - oligonucleotide trimer.

The proton spectra of both isomers were assigned with
the aid of COSY, NOE, RCT , and decoupling experiments.
Variable temperature chemical shift plots and the use of
first order coupling constants in various "Karplus-styled"
equations allowed for the building of a solution structure
model of the CUG high molecule that proved to adhere to
Sundaralingam's "rigid" nucleotide concept (1973). The 5'-5'
phosphodiester bond adopted a zig-zag right handed helical
conformation with the terminal ribose oriented with the H-1'
away from the center of base-stacking . This placed the C
more distant from U and resulted in U/G base-stacking taking
precedence over the dominant C/U base-stacking present in CUG
low. The presence of the 5'-5' phosphodiester did not
greatly effect the backbone structure of the adjacent 3'-5'
linked phosphodiester bond.

Both trimers were digested with Phy M to remove the G. Dimers with 2'/3' cyclic Us were obtained and compared with
3'-5' CpU.

The presence of a 5'-5' phosphodiester bond allowed
for a near complete assignment of the C-13 spectra of the two
isomers. These spectra represent an addition to the small
number of C-13 spectra available on ribo-oligonucleotide
trimers.

The P-31 spectrum of CUG low was unambiguously
assigned by selective CW proton decoupling. The high isomer
spectrum was interpreted on the basis of this assignment and
revealed a substantial downfield movement in the chemical
shift of the phosphorus involved in the 5'-5' bond.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Risk, M.J.
Geology

abstract: Title: The Petrography and Chemistry of Fossil Burrow Margins, Author: Steven C. Harding, Location: Thode

abstract:
A great deal of information may be attained from trace fossils. Burrow margins represent zones of complex interactions, which may be recognized in the rock record. Sediment deformation results during organism penetration and reoriented particles tend to align with the burrow structure. Sixty-five percent of all elongate grains show less than 10° tangential deviation parallel to burrow length, and 82% less than 20° tangential deviation for grains measured around the circular burrow cross-section. As suggested by fluid dynamic theory, fluctuation in burrowing velocity appears to induce grain rotation. Sediment type and fluidity,
in conjunction with the nature of burrowing, will control the preservation of reoriented grains.

Burrow walls are sites of metal accumulation. Metal cations become complexed to metabolites associated with decomposition of marginal organics, or to clay minerals entering the burrow. Some of these metals may also "scavenge" additional cations out of irrigated seawater. Concentrations are preserved as oxides or metal-rich cements within the marginal zone; characteristic of only those structures which are organically induced. Electron probe scans across burrow structures produce high relative peaks for Fe, Al, Cu and Ni in the wall region.

 These analyses may allow valuable interpretations, expanding the realm of Ichnology.

abstract: Thesis

abstract: Bachelor of Science (BSc)


title: The Effect of Low Temperature on the Physico-Chemical Treatment of Domestic Wastewater

contributor:
Benedek, A.
Chemical Engineering

subject: low temperature, physico-chemical, treatment, domestic, wastewater, polyelectrolyte

abstract:
 The effect of low temperature on the physico-chemical treatment (PCT) of domestic wastewater is examined with special emphasis placed on activated carbon adsorption. PCT is a recent processing scheme, wherein wastewater goes through sedimentation, precipitation, deep bed filtration and adsorption. In PCT, activated carbon adsorption takes the place of conventional biological treatment for organic removal.

 Both batch studies using powdered activated carbon (PAC) and continuous flow studies with granular activated carbon (GAC) on a pure compound, sodium dodecyl sulfate (SDS) and domestic wastewater from the Dundas, Ontario Water Pollution Control Plant were investigated.

 Theoretical analysis and batch feasibility studies indicate that the effect of low temperature on coagulation, flocculation and sedimentation were quite easily handled within established design parameters. Batch studies on PAC treatment show that the carbon floc is easily separable from wastewater with the aid of a small dosage of polyelectrolyte and high effluent quality is obtainable at temperatures ranging from 2° - 25°C.

 Granular activated carbon was evaluated first on a pure compound, SDS. Batch isotherms and kinetics were also conducted at the same time to determine parameters needed for continuous flow modelling. Results derived from this phase of the study indicate that the activation energy from column studies is quite low (approximately 3.0 kcal/mole). Close match is obtained between the theoretical model (a modification of Thomas' reaction kinetics) and experimental data.

 Finally PCT pilot plant studies on domestic wastewater were carried out, at 5°C and 25°C. Soluble organic carbon removal was in excess of that predicted by purely adsorption type phenomenon. This is attributed to microbial activity inside the carbon columns. Greater soluble organic removal was seen at 25°C than at 5°C. Denitrification inside the carbon columns was found to be quite significant, again with stronger denitrifying activity at 25°C than at 5°C. Microbiological investigation of the carbon from the exhausted columns revealed over 10^9 cells/cm^3) of GAC bed volume from the lead column at 25°C. Denitrifiers were also detected in the carbon. Iodine numbers were determined on used carbon, which indicated the exhaustion of activated carbon capacity. Organic removal, however, continued undiminished, due to bacterial activity.

 The study culminated with the development of a theoretical model incorporating bacterial activity. The results of column effluent profile, however, indicated great discrepancy between theoretical predictions and experimental observations. This was attributed to simplistic assumptions utilized in solving the fixed bed problem.

abstract: Thesis

abstract: Master of Engineering (MEngr)


title: ESR Isochron Dating of Speleothems

contributor:
Schwarcz, Henry P.
Geology

abstract: Title: ESR Isochron Dating of Speleothems, Author: Iakovos Karakostanoglou, Location: Thode

abstract:
Calcium carbonate precipitated in caves (speleothem) may contain more than 1 ppm of U but is devoid of Th or K. The major part of its natural radiation dosage (NRD) may have arisen internally from U and its short-lived daughters. By analysing adjacent, approximately coeval samples with varying U content, it is possible to construct an isochron of NRD versus U content which, when extrapolated to zero, gives the external NRD component. The slope of the isochron is a function of the age of the samples, taking into account appropriate corrections for disequilibrium between U-series daughter isotopes, and alpha-particle ESR efficiency ("a"-factor). Using speleothems which have been dated by the 230Th/234U method, the above procedure has been reversed to determine the average "a"-factor of the samples, and to establish that its values lie around 0.1.

Several discrete and reproducible ESR peaks of approximately constant g-value have been observed in speleothem calcites. The main peak (S 1A) with g=2.0008(±2), fades at approximately 220°C and corresponds to the principal TL peak, used for dating so far. Other weaker peaks of various g-values and fading temperatures are also radiation-sensitive. Several other peaks are present which are associated with Mn2+. Low-temperature annealing has a mild effect on the main peak, probably due to retrapping. This peak varies greatly with grain size, decreasing by more than half for particles less than 100 μm.

abstract: Thesis

abstract: Master of Science (MS)


contributor:
Ford, D.C.
Geography

abstract: Title: Fluvial Geomorphology on a Glacial Till Plain, Author: Alan D. Jackson, Location: Thode

abstract:
Fluvial channel adjustment on a glaciated till plain in
Southern Ontario is investigated. Mallot River, a component
of the Grand River system is used as an example. Concepts of
equilibrium and underfitness are discussed. Field studies
include over thirty miles of longitudinal and transverse
valley profiles. Laboratory investigation produced a detailed
map from air photographs. It contains more than 15,000 First
Order segments. Morphometric analyses were conducted using
this base. A hierarchy of drainage density is suggested. A
comparison with drainage on non-glaciated material concludes
the study.

abstract: Thesis

abstract: Master of Science (MS)


title: The Multilingual Jesus: An Analysis of the Sociolinguistic Situation of Ancient Palestine with Special Reference to the Gospel of Matthew

contributor:
Porter, Stanley E.
Westfall, Cynthia Long
Christian Theology

subject: multilingual, Jesus, sociolinguistic, Ancient Palestine, Gospel of Matthew, Christianity

abstract: Was Jesus multilingual? Which languages did he speak? What does the linguistic composition and sociolinguistic situation of first-century Palestine look like? On what occasions were Hebrew, Aramaic, Greek, and Latin spoken in that ancient community? These questions have biblical scholars searching for answers since the sixteenth century, proposing different opinions on the issues related to these questions. Answers to these questions significantly influence our understanding of the various sociolinguistic elements and facets of early Christianity, the early church, and the text of the New Testament. But those answers depend upon our depiction of the multifarious sociolinguistic dynamics that compose the speech community of ancient Palestine, which include its historical linguistic shifts under different military regimes, its geographical linguistic landscape, the social functions of the languages in its linguistic repertoire, and the specific types of social contexts where those languages were used. Using a sociolinguistic model, this study attempts to paint a portrait of the sociolinguistic situation of ancient Palestine, consequently providing answers to these questions.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: The Application of Molecular Signatures and Phylogenomic Techniques to The Classification and Identification of Prokaryotic Organisms

contributor:
Gupta, Radhey
Biochemistry and Biomedical Sciences

subject:
Evolution
Genomics
Molecular Signatures
Phylogeny
Taxonomy
Classification

abstract: The advent of large-scale genomic sequencing is providing researchers with an unparalleled wealth of information which can be used to elucidate the evolutionary relationships of living organisms. The newly available genome sequence data have enabled the use of comparative genomic techniques for the identification of novel molecular signatures, shared uniquely by evolutionarily related groups of organisms: conserved signature indels (CSIs) and conserved signature proteins (CSPs). These signatures allow for the unambiguous delineation of the prokaryotic taxa, independent of gene and genome based phylogenetic trees, and provide insights into novel aspects of their evolutionary relationships. The phylum Spirochaetes and the class Betaproteobacteria are large, diverse groups of bacteria, containing many important pathogenic and environmental organisms, which are classified primarily on the basis of 16S rRNA gene analysis. Here, I describe phylogenetic analyses of the phylum Spirochaetes based on genome derived molecular signatures. These analyses have yielded substantial evidence for differentiation between the three main sequenced groups of organisms within the phylum Spirochaetes and between the genus Borrelia from other closely related Spirochaetes. These findings have prompted a proposal to create three new orders and a new family within the phylum. These analyses have also supported the differentiation of two clinically distinct groups within the genus Borrelia and a proposal to divide the genus Borrelia into two genera. The use of molecular signatures and phylogenetic analysis of major groups within the class Betaproteobacteria are also described. The analyses of the order Neisseriales within this class resulted in a division of the order into two families, while the analyses of the genus Burkholderia supported the differentiation of the clinically relevant members of the genus Burkholderia from the plant-beneficial and environmental Burkholderia and a proposal to divide the genus into two genera. I also describe the use of phylogenomic techniques and molecular signatures to differentiate the seven main groups within the order Enterobacteriales and the integrated software pipeline used to produce the supermatrix based phylogenomic tree and genome distance calculations in the analysis of the order Enterobacteriales. The molecular signatures described in this thesis represent powerful new tools for evolutionary and systematic studies. Additionally, due to their taxon specificity, these molecular signatures are novel diagnostic markers for their specified group. Further analyses of these molecular signatures should lead to the discovery of novel functions and biological characteristics, mediated by CSIs and CSPs, which will provide important insights into the physiology, evolution, and adaptations of these groups.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Of Conflict and Concealment: The Gospel of Mark as Tragedy

contributor:
Porter, Stanley E.
Land, Christopher D.
Christian Theology

subject: conflict, concealment, Gospel of Mark, tragedy, Jesus, Messiah

abstract:
 Perhaps since its composition, the Gospel of Mark has troubled scholarship with regard to
its content and genre. In it, a number of anomalies appear: Jesus' use of secrecy, Jesus' use of the "son of man" title, how the miracles and exorcisms function with regard to plot, and why Jesus never convinces his listeners of his message. In this study, I argue that these anomalies can be explained by considering Mark's Gospel in light of the tragic genre. Mark's Gospel does not simply contain motifs or modes from tragedy; Mark's Gospel is a tragedy. Through the
examination of extant Greek Tragedy and an application of Hegel's theory of tragic Kollision,
this study illustrates the ways in which the plot of Mark's Gospel is built upon a tragic
foundation. Kollision describes how Jesus is in conflict as the tragic hero. Conflict becomes
central to this study, in which Jesus is the antagonist to the Temple and the cultural ethos it
creates. This antagonism defines Jesus as the Messiah and concealed Son of God, and it produces the suffering and death common to all of tragedy. What is more, this study critically engages with several tragic theories, ranging from ancient to modern. It specifically analyzes Aristotle's Poetics-the standard description of tragic genre-and ask whether Aristotle's categories really do provide an exhaustive definition of ancient tragedy.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Neural Precursor Cell Biology in the Postnatal Fmr1-Knockout Mouse Hippocampus

contributor:
Doering, Laurie
Neuroscience

subject:
Fragile X Syndrome
Neural Precursor Cells
Astrocytes
Fmr1-KO mice

abstract: The regulation of neural precursor cells (NPCs), which encompass neural progenitor and neural stem cells (NSCs), is fundamental for proper brain development and function. These cells are regulated by orchestrated signalling within their local environment. Aberrant aspects of cell proliferation, differentiation, survival, or integration have been linked to various neurological diseases including Fragile X syndrome (FXS)—a disorder characterized by intellectual and social changes due to the silencing of the gene encoding FMRP. The biology of hippocampal NPCs in FXS during early postnatal development has not been studied, despite high FMRP expression levels in the hippocampus at the end of the first postnatal week. In this thesis, the Fmr1-knockout (KO) mouse model was used to study hippocampal cell biology during early postnatal development. A tissue culture assay, used to study the effect of astrocyte-secreted factors on the proliferation of NSCs, indicated that astrocyte secreted factors from Fmr1-KO brains enhanced the proliferation of wild type, but not Fmr1-KO NSCs (Chapter 3). Next, the proliferation and cell cycle profiles of NPCs in vitro and in vivo studied with immunocytochemistry, Western blotting, and flow cytometry revealed decreased proliferation of NPCs in the Fmr1-KO hippocampus (Chapter 4). Finally, cells isolated from the P7 dentate gyrus and characterized by flow cytometry, showed a reduced proportion of NSCs and an increased proportion of neuroblasts—neuronal committed progenitors—in Fmr1-KO mice. Together, these results indicate that hippocampal NPCs show aberrant proliferation and neurogenesis during early postnatal development. This could indicate stem-cell depletion, increased quiescence, or a developmental delay in relation to lack of FMRP and uncovers a new role for FMRP in the early postnatal hippocampus. In turn, elucidating the mechanisms that underlie FXS will aid in the development of targeted treatments.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)

abstract: Fragile X syndrome is the leading inherited cause of intellectual impairment and autism spectrum disorder. The syndrome is caused by a defect in one gene. This gene has been suggested to play a role in regulating the birth of new brain cells termed neural precursor cells. The importance of neural precursor cells stems from their ability to generate neurons and glia, the main cells in the brain. In this thesis, I focus on studying neural precursor cells from the hippocampus, a brain region important for learning and memory. A mouse model was used to compare neural precursor cells from healthy and Fragile X mice during early postnatal development. I found that neural precursor cells do not divide as much as they should in the Fragile X mouse hippocampus. The results help to determine the causes for learning and memory deficits in Fragile X and potentially open avenues for intervention.


title: Applications of chance constrained optimization in operations management

contributor:
Deza, Antoine
Huang, Kai
Computational Engineering and Science

abstract: In this thesis we explore three applications of chance constrained optimization in operations management. We first investigate the effect of consumer demand estimation error on new product production planning. An inventory model is proposed, whereby demand is influenced by price and advertising. The effect of parameter misspecification of the demand model is empirically examined in relation to profit and service level feasibility, and conservative approaches to estimating their effect on consumer demand is determined. We next consider optimization in Internet advertising by introducing a chance constrained model for the fulfillment of guaranteed display Internet advertising campaigns. Lower and upper bounds using Monte Carlo sampling and convex approximations are presented, as well as a branching heuristic for sample approximation lower bounds and an iterative algorithm for improved convex approximation upper bounds. The final application is in risk management for parimutuel horse racing wagering. We develop a methodology to limit potential losing streaks with high probability to the given time horizon of a gambler. A proof of concept was conducted using one season of historical race data, where losing streaks were effectively contained within different time periods for superfecta betting.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Symptom Onset to First-Medical-Contact in ST-Segment Elevation Myocardial Infarction Patients

contributor:
Schwalm, Jon-David
Natarajan, Madhu
ElGuindy, Ahmed
Global Health

subject:
Time Delays
STEMI

abstract: ST-segment elevation myocardial infarctions (STEMI) make up approximately 25% to 40% of total myocardial infarction (MI) presentations. The total occlusion of the coronary artery that results in a STEMI makes timeliness to reperfusion crucial. Previously, the focus has been on decreasing door-to-balloon time (D2B). Although D2B time plays an important role in achieving timely treatment, it is only one component of the route from symptom onset to reperfusion. It has been shown that total ischemic time is a better predictor of clinical outcomes, including mortality and infarct time. Delays between symptom onset to first-medical-contact (FMC) consume the majority of total ischemic time, and remains one of the main reasons that patients do not receive timely care. Factors affecting symptom onset to FMC for STEMI patients receiving primary PCI as a method of reperfusion at the Aswan Heart Center (AHC) in Egypt and the Hamilton General Hospital (HGH) in Canada were examined using the prospectively collected data held in the STEMI registries at these sites and a modified version of the Response to Systems Questionnaire applied in Egypt. Exploring factors linked to early and late presentation in STEMI patients showed that delays were associated with gender, smoking, cardiac history, cardiogenic shock and mortality rate. Furthermore, the type and number of symptoms, presence and actions of bystanders, emotional response and the actions of the patients, as well as transportation time was shown to be different among delay groups.

abstract: Thesis

abstract: Master of Science (MSc)


title: Studying Macrophage Receptor Evolution and Function using Bioinformatics

contributor:
Bowdish, Dawn
Golding, Brian
Biology

abstract:
During infection, macrophages are important for the uptake and clearance of mi- crobial products, and producing inflamamtory cytokines. Receptors on the surface of the macrophage bind to bacterial components, and initiate inflammatory pathways. Although it is known that this inflammatory response is mediated through surface re- ceptors, the regulation of this response and the evolution of these receptors remains un- clear. This work uses a bioinformatic approach to study the effect of age on lipopolysac- charide (LPS) tolerized macrophages, and the evolution of the class A Scavenger Recep- tors (cA-SRs).
Previous work has shown that the cA-SRs are evolutionarily related to each other, however the exact nature of this relationship remains unclear because of differences in the functional domains of the proteins. Several of the cA-SRs possess a Scavenger Re- ceptor Cysteine Rich (SRCR) domain, however its exact function and origin remains un- known. Previous studies have shown the SRCR domain is involved in ligand binding in the MAcrophage Receptor with COllagenous structure (MARCO), a member of the cA-SR family. Using recently identified extant species, we show that the SRCR domain has a common origin within the cA-SRs and that several areas within the SRCR domain are under positive selection within MARCO. In addition, recent functional data sug- gests that MARCO may be co-evolving with the Toll-Like Receptor 2 and CD14 Using a model of 40 non co-evolving proteins, we show that MARCO has indeed co-evolved with TLR2 and CD14. We also identified a polymorphism within the collagenous do- main of MARCO that contains a human specific variant. Future experiments to confirm these bioinformatic predictions can further our understanding of macrophage biology and the innate immune system.

abstract: Thesis

abstract: Master of Science (MSc)

abstract:
The Class A Scavenger Receptor (cA-SRs) are a group of phagocytic receptors on the

surface of macrophages. The cA-SRs consist of five family members including the

Macrophage Receptor with COllagenous structure (MARCO) and the class A

Scavenger Receptor (SR-A). Previous work has shown that these receptors are

evolutionarily related, however the exact nature of this relationship remains unclear

because of differences in the functional domains of the proteins. Using extant

sequences from each of these receptors, from multiple species, we have investigated

the evolution of the cA-SRs.


title: Steady State Modelling and Parametric Study of a Vapor Recompression Distillation Unit

contributor:
Johnson, A. I.
Chemical Engineering

subject: steady state, modelling, parametric, Vapor recompression, distillation, polymer, CHESS simulation,

abstract:
 Steady state heat and mass balancing around an ethylene/ethane distillation unit at Polymer Corporation, Sarnia is studied using the CHESS simulation executive system.

 The unit involves a single column with reboiler heat provided by recompression of the overhead vapor stream.

 A new column model is developed, based on the approximate pseudo-binary method of Hengstebeck, and is shown to give good results with marked savings in computation time over the conventional tray to tray methods. Models for vapor compression and heat exchange are also presented.

 The system model is fitted to plant data and a routine developed to obtain satisfactory system convergence.

 A parametric study is carried out in which column pressure and distillate product enthalpy are varied to demonstrate significant improvements in plant operation.

 An evaluation of the CHESS simulation system is presented.

abstract: Thesis

abstract: Master of Engineering (MEngr)


title: Canadian Economic Development in Southeast Asia

contributor:
Lonergan, S. C.
Geography

subject: Canadian, economic, development, trade, investment

abstract:
 The focus of Canadian trade and investment has shifted from the Atlantic to the Pacific region. This paper looks at the increase in Canadian trade and investment within one area of
the Pacific region, the Association of Southeast Asian Nations. Trade between Canada and ASEAN, from 1970 to 1983, is analyzed. Canadian involvement in ASEAN is measured
through general investment data, and a survey of some Canadian firms in the region. Recommendations are given for continued Canadian economic involvement in ASEAN.

abstract: Thesis

abstract: Candidate in Philosophy


title: Products and Factorizations of Graphs

contributor:
Sabidussi, G.
Mathematics

subject: products, factorizations, graphs, prime, isomorphisms

abstract: It is shown that the cardinal product of graphs does not satisfy unique prime factorization even for a very restrictive class of graphs. It is also proved that every connected graph has a decomposition as a weak cartesian product into indecomposable factors and that this decomposition is unique to within isomorphisms. This latter result is established by considering a certain class of equivalence relations on the edge set of a graph and proving that this collection is a principal filter in the lattice of all equivalences. The least element of this filter is then used to decompose the graph into a weak cartesian product of prime graphs that is unique to within isomorphisms.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Design and Implementation of a High-Speed Inverse Walsh Transform Apparatus

contributor:
Elliott, A. R.
Electrical Engineering

subject: design, implementation, high-speed, inverse, Walsh transform apparatus, clock rate, pulse, adder

abstract: In this thesis, a high-speed inverse Walsh transform apparatus was designed and built which sums over the sixteen most dominant coefficients in the time base period. The transform includes a maximum of 64 terms. The Walsh function generator used works with a clock rate up to 10 MHz to produce 64 different sequency terms with accurate timing and hazard free operation. A synchronizing pulse is produced by the circuit to determine the beginning of the Walsh transform period. The final adder stage limits the speed of the apparatus to a 1 MHz square wave. An application of the instrument was made to reconstruct one line of an actual video signal.

abstract: Thesis

abstract: Master of Engineering (MEngr)


contributor:
Wood, H.A.
Geography

abstract: Title: Settlement Migration in Central Bonavista Bay Newfoundland, Author: Clifford G. Head, Location: Thode

abstract:
During the last two decades, the islands of Bonavista Bay --a large bay of Northeastern Newfoundland-- have been swept almost totally clear of settlements. Many of the dwellings
were floated to the local mainland to join existing communities, or to found new and separate settlements. To describe and to explain this dramatic movement, this study probes the establishment of a permanent population in Central Bonavista Bay, and its development over more than two centuries to the mid-1950's, paying particular attention to the factors of development which influenced the recent migrations. The traditional way of life of the archipelago settlements is detailed, as are the basic changes which brought about the settlement migrations. Finally, the conditions in 1964 are examined, and an attempt is made
to predict the future of the area.

abstract: Thesis

abstract: Master of Arts (MA)


title: Optimal Tolerance Allocation

contributor:
Siddall, J. N.
Mechanical Engineering

subject: optimal, tolerance, allocation, convex, design, variables

abstract:
 This thesis addresses itself to one of the most general theoretical problems associated with the art of engineering design. Viewed in its entirety the proposed approach integrates the relation between the design and production engineers through the theory of nonlinear optimization. The conventional optimization problem is extended to include the optimal allocation of the upper and lower limits of the random variables of an engineering system. The approach is illustrated by an example using a sequence of increasingly generalized formulations, while the general mathematical theory is also provided. The method appears to offer a practical technique provided a satisfactory cost function can be defined.

 The thesis presents an analytical approach to full acceptability design conditions as well as less than full acceptability or scrap design conditions. An important distinction between the design and the manufacturing scrap has been introduced and illustrated through examples.

 The space regionalization technique is utilized to estimate the system design scrap. Optimization strategies are introduced to the mathematically defined upper and lower limits of the regionalization region. This region is then discretized into a number of cells depending upon the probabilistic characteristic of the system random variables.

 The analytical approach exhibited does not rely explicitly on evaluation of partial derivatives of either the system cost objective or any of its constraints at any point. Moreover, the technique could be applied to engineering systems with either convex or nonconvex feasible regions. It could also be exercised irrespective of the shape of the probabilistic distributions that describe the random variables variation.

 Industrially oriented design examples are furnished to justify the applicability of the theory in different engineering disciplines.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


contributor:
Norman, J.D.
Civil Engineering

abstract: Title: A Continuous Biochemical Reactor Study Using Mixed Microbial Cultures, Author: Howard A. McLean, Location: Thode

abstract:
A completely-mixed biochemical reactor was used to study a mixed microbial culture using soluble organic carbon in the form of glucose as a growth limiting nutrient. The effect of various flow rates and feed concentrations was determined by evaluating the corresponding variations in unit organism growth rate, yield and effluent carbon concentration.

The effluent carbon concentration was independent of flow rate and feed concentrations for the range studied. The unit growth rate was similarly independent of the feed concentration but varied directly as the flow rate. No trend indicated that yield varied with either flow rate or
feed concentration. Large variations in yield often occurred at any one condition due to changes in the mixed microbial population. However, the reason for this microbial variation was not determined.

abstract: Thesis

abstract: Master of Engineering (ME)


contributor:
McNutt, R.H.
Geology

abstract: Title: The Petrography, Geochemistry, and Petrogenesis of Two Granite Suites, Churchill Province, Thekulthili Lake, N.W.T., Author: D. Keith MacDonald, Location: Thode

abstract:
A petrographic and geochemical analysis has been carried out on two granite suites with contrasting morphologies and field relations. Included is a discussion of their age relationships
relative to the Nonacho Series supracrustal sequence. The respective petrographic and petrochemical features of the two granitoids is given; followed by a comparison of the two, and a discussion on their modes of petrogenetic evolution. Petrographic descriptions of selected Nonacho supplement the granitoid study.

Analytical methods and a discussion of the results are included.

abstract: Thesis

abstract: Bachelor of Science (BSc)


title: Rama Township

contributor:
Reeds, L.G.
Geography

abstract: Title: Rama Township, Author: Georgia Henderson, Location: Thode

abstract:
This thesis is a regional study of the physical and human geography of Rama Township. An area of 35,954 acres, it is situated on the east shore of Lake Couchiching. Within the township's boundaries there are two lakes - Lake St. John (pronounced Sin-jun) and Mud Lake . There are also several rivers, the most important being the Black River and its tributary, the Head River. The Severn River marks the north-western limit of the township. Two railways,
both Canadian National, traverse the area, converging at Washago. Highway 11 and 12 lead to Rama from large population centres. There are 81 miles of road within the township. Highway #69 is provincial and follows the Couchiching shore. Although gravel, it is kept in fair condition. There is one county road reaching from O'Connell to Fawkham which is also well kept. The remaining are township roads and are not usually in very good condition. Rama Township has a population of 653. Of these, 379 are concentrated along the lakeshore. There is an additional 375 Indian residents. 1. A large summer population, much of which is transient, swells this total during the warmer months . The progress of Rama has been limited to some extent by the environment. In some cases, the people have overcome difficulties and made very satisfactory adjustments to adverse conditions. Yet if the people
of Rama Township could understand their environment more fully, they would be able to gain a more balanced economy, a more efficient land utilization, and some types of specialization which would provide a surplus for sale outside of the township . If this could be done, the threatening bonds of self-sufficiency would be broken.

abstract: Thesis

abstract: Bachelor of Arts (BA)


title: Studies of Euglena Mutants Resistant to U.V. and Nitroso Compounds

contributor:
McCalla, D. R.
Biology

subject: Euglena Mutants, resistant, nitroso compounds, mutagens, U.V. light

abstract: In order to compare the mode of action of mutagens which cause mass conversion of green Euglena to colorless forms lacking chloroplasts, mutants were selected either for resistance to U.V. light or for resistance to N-methyl-N-nitroso-p-toluenesulfonamide (MNTS). The U.V. resistant mutants selected showed strong resistance to U.V. but the slow growth of these mutants indicated that they probably carried multiple lesions. Some of the problems inherent in selection techniques were explored and discussed. A mutant selected for resistance to MNTS was found to have the ability to convert MNTS to an innocuous compound N-methyl-p-toluenesulfonamide. Experiments using the MNTS resistant strain provide information concerning the mode of action of MNTS and the related mutagen nitrosoguanidine.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


contributor:
Smeltzer, W.M.
Metallurgy

abstract: Title: The Oxidation Properties of Iron-Nickel Alloys in CarbonDioxide-Carbon Monoxide Atmospheres at 1000°C, Author: Larry A. Morris, Location: Thode

abstract:
In this thesis, the results of oxidation tests carried out on iron-nickel
alloys in carbon dioxide - carbon monoxide atmospheres at 1000°C are
presented. Linear oxidation kinetics were observed for the formation of
wustite on alloys containing up to 50 weight % nickel. Spinel oxides appear
on alloys containing greater them 50% nickel. A subscale developed in
all alloys investigated. An oxidation model is presented for the constant
uptake of oxygen based on detailed balancing of the individuol reaction
steps, assuming thet dissociation of carbon dioxide is the rate controlling
process. The subscale formation mechanism is based on the principles of
diffusion in multicomponent metallic systems . Theoretical relationships
are presented which adequately account for the experimental observation

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Factors Affecting Ground Ice Melting

contributor:
Rouse, W. R.
Geography

subject: factors, ground ice, melting, temperature, moisture gradients, thermal, environmental

abstract:
 The thaw rates of the active layer above the permafrost zone from a series of sites along the Hudson Bay coastline at lat. 56° have been examined with respect to temperature and moisture gradients, the characteristics of the surface layer and the bulk thermal properties for
each profile. The thermal properties have been examined using firstly a Fourier approach with the parameter of degree days and using secondly a graphical approach employing thermal relationships obtained in the laboratory analyses by Kersten (1949).

 It was found that thaw rates are controlled by the interaction of a number of environmental factors of which vegetation appears to be the most important.

 The two approaches to the derivation of thermal properties give quite different results, such that the graphical approach is deemed to be unsuitable to field application.

abstract: Thesis

abstract: Bachelor of Science (BSc)


contributor:
Middleton, Gerard V.
Geology

abstract: Title: The Sedimentology and Petrography of the Whirlpool Sandstone (Lower Silurian) in Outcrop and Subsurface in Southern Ontario and Upper New York State, Author: Margaret A. Rutka, Location: Thode

abstract:
The Whirlpool Sandstone (Lower Llandovery) is a
thin, sheet-like sandstone, less than 9 m thick, forming the
base of the Medina Group in Southern Ontario and western New
York. Two very distinct units, a lower and an upper, are
recognized in the Whirlpool. The lower unit lacks body and
trace fossils, marine microfossils, and wave-formed
structures, and is interpreted as being terrestrial in
origin. The facies and facies associations, erosional
facies relationships, consistent northwest paleocurrents,
and lack of lateral and vertical accretion deposits all
support a braided fluvial interpretation. Three facies
associations, each characterized by different amounts of the
trough and ripple cross-laminated and horizontal-laminated
facies, are present and are indicative of downstream changes
in the river's fluvial style, from a moderately braided
river with relatively deep channels in the southeast to a
more highly braided river with very shallow channels, in the
northwest. Erosional facies relationships and abundant mud
intraclasts in the Whirlpool suggest that the river
experienced frequent stage fluctuations. The upper unit
consists predominantly of interbedded sandstone and shale
and bioturbated sandstone, and contains fossils, trace
fossils (Skolithos and Cruziana ichnofacies), wave-formed structures and shallow water indicators. The upper
Whirlpool formed in a storm-influenced, low-energy nearshore
zone of a shallow, low-gradient epeiric sea, where 'normal'
wave energy was dissipated some distance from the shoreline.
Northwest- to southeast-striking symmetrical ripples
indicate that the transgression probably came from the
southwest.

The Whirlpool is a moderately spherical, rounded,
well-sorted subarkose. No compositional differences exist
between the upper and lower Whirlpool. The porosity is
secondary, comprises less than 3% of the rock, and shows no
regional or vertical trends. Regionally, the Whirlpool's
grain size shows an overall fining to the northwest.
Vertically, the Whirlpool shows an overall fining upward
trend with smaller fining-upward cycles (stacked channelfills)
superimposed on this trend. The sandstone's
mineralogical and textural maturity suggests a second cycle
or multicycle origin. The Oswego Sandstone may be the
Whirlpool's source.

A model of lithospheric flexure is used to explain
various aspects of the Whirlpool's deposition. Deposition
of the fluvial Whirlpool occurred on the northwest side of a
northwest-migrating peripheral bulge which formed in
response to overthrust loading in the southeast. Complex
lithospheric interactions of the Michigan and Appalachian
Basins and loading in the south caused the depositional plain to be tilted to the southwest, initiating the
transgression over the lower Whirlpool. The presence of a
deeper-water facies (Cabot Head Shale) overlying the
Whirlpool in the south than in the northwest (Manitoulin
Dolomite) suggests that the transgression may have come from
the south-southeast, as well.

abstract: Thesis

abstract: Master of Science (MS)


title: Burlington An Urban study

contributor:
Thampson, H.R.
Geography

abstract: Title: Burlington An Urban study, Author: John A. McCallum, Location: Thode

abstract:
The town of Burlington, located at the southwestern corner of
Lake Ontario {see Figure 1), has for the past fifteen years been growing
at a startling rate. Startling, for in this brief period of time the
population has roughly tripled. Noted just a few years ago for its farms
and orchards, the town has in recent years become a beehive of residential,
commercial and industrial activity. What factors have been responsible for
this transition? How has it taken place? How have these factors affected
the pattern of man's life in Burlington? It is the purpose of the following
chapters to examine and to answer these questions.

abstract: Thesis

abstract: Bachelor of Arts (BA)


title: North Gimsby Township

abstract: Title: North Gimsby Township, Author: Donald M MacLEOD, Location: Thode

abstract:
North Grimsby township occupies a unique position. Not
only does it form a part of the famous Niagara Falls Belt, but it is
also situated half way between the two industrial areas of the
Niagara Peninsula, Hamilton to the west, and Niagara- St.Catharines
to the east. As well, it is virtually cut in two by the Niagara
Escarpment which runs in an east -west direction through the township. The township forms the north-west corner of Lincoln
County; to the north is Lake Ontario; immediately west is Baltfleet
Township of Wentworth County; to the south and east, respectively,
are South Grimsby and Clinton Townships, both of Lincoln County.
North Grimsby Township lies between 43° 9' north latitude and 43° 14'
north latitude and between 79° 31' west longitude and 79° 39' west
longitude. Its western boundary bears North 18° East; the southern
boundary East 18° South and the eastern boundary bears approximately
North-South. The general shape of the township is rectangular,
modified greatly on the north by Lake Ontario. Discounting the
irregularity of this northern boundary, the area of the township is
approximately 28 square miles, seven miles from east to west and four
miles from north to south. The two main highways and one of the rail lines of the township run east and west and this, combined with
the prominence of the Niagara Escarpment and the narrowness of the
lake plain, tends to emphasize the rectangular shape.

abstract: Thesis

abstract: Bachelor of Arts (BA)


title: Intimacy with God: A Reorienting Pastoral Theological Reflection Upon Church Decline

contributor:
Zylla, Phil C.
Knowles, Michael P.
Christian Theology

subject: intimace, God, pastoral, theological, Church decline, spiritual, fear, love

abstract:
 This dissertation offers a reoriented perspective of church decline as discerned through a process of pastoral theological reflection. The conversation partners are: (1) statistical indicators of church decline; (2) case studies of church decline as described by congregational studies research; (3) church renewal materials; (4) elements of grief theory; and (5) theological and spiritual resources related to God's power and presence in weakness. Statistical indicators suggest that decline is still an issue for local churches today. In response to this ongoing situation of decline, myriads of renewal materials have been produced offering ways and means for the church in North America to be renewed. Unfortunately these materials, and the assumptions which undergird their proposals, can be detrimental to declining churches, and fail to address the actual experience of decline as revealed by the case studies. For this reason, this dissertation offers a reoriented perspective of decline. It is a perspective that affirms that even those churches suffering the effects of decline can experience intimacy with God, and participate in God's fruitfulness. This perspective affirms, in concert with grief theory, that declining churches will need to acknowledge and mourn their losses brought about by decline. It also asserts, however, that theological and spiritual resources are needed to support churches in this regard. To this end, two theological and spiritual polarities will be offered for the purpose of articulating the reorienting perspective. The first polarity involves the movement between decline and a focus upon God as the One who re-describes our experience of decline. The second polarity involves the movement
between an avoidance of decline and a focus upon God as the One who is present with us in it. Ultimately both of these polarities are understood as being grounded in the movement between fear and love. This pastoral theological reflection upon church decline is offered as a means of bringing hope and encouragement to those churches struggling with decline. Decline is serious, but it can also be an occasion of experiencing a profound deepening of the church's relationship and ministry with God.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Procoagulant and Anti-Fibrinolytic Properties of Cell-free DNA and Histones in Sepsis

contributor: Medical Sciences (Blood and Cardiovascular)

subject: Sepsis Histone DNA

abstract:
Sepsis is a devastating clinical condition characterized by a systemic inflammatory response to infection, with concomitant dysregulated pathological thrombus formation. Although sepsis is triggered by the release of microorganisms and/or microbial toxins into the circulation, the presence of infection itself is rarely the cause of death in these patients. Rather, mortality in sepsis is attributed to irreversible organ damage resulting from prolonged, uncontrolled activation of inflammatory and coagulation pathways within the microcirculation. Despite recent advances in clinical management, treatment continues to be largely supportive in nature. As a result, sepsis remains the leading cause of morbidity and mortality in non-coronary intensive care units with mortality rates ranging from 18-30%. Sepsis-induced mortality is further increased following the development of disseminated intravascular coagulation, a thrombohemorrhagic state defined by a primary thrombotic and secondary hemorrhagic diathesis that may culminate in multi-organ failure.
Clinical management of patients with sepsis is challenging and largely limited to supportive therapies, which is in part related to a limited understanding of the underlying pathophysiology. Recently, cell-free DNA (CFDNA) has emerged as an important link between innate immunity, coagulation, and inflammation. Furthermore, we have previously demonstrated that plasma levels of CFDNA have high discriminative power to predict ICU mortality in patients with severe sepsis. Patients with higher plasma concentrations of CFDNA are more likely to face severe complications such as organ dysfunction/failure, and death. The evidence presented in this thesis suggests that CFDNA may not simply be an innocuous marker of disease severity, but may itself exert pathological effects and contribute to the fatal coagulation abnormalities observed in sepsis patients.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Game Theoretic Revenue Management Models for Hotel Room Inventory Control

contributor:
Parlar, Mahmut
Business

subject: game, theoretic, revenue, management models, hotel room, inventory, control, Nash equilibrium

abstract:
 In this thesis, we focus on the rationing polices for the hotel room inventory control problems. Our study begins with a brief overview of revenue management in hotel industry, emphasizing the importance of room inventory control in revenue management problems. Mathematical models for controlling the room inventory in the literature are then reviewed along with recently developed game theoretic applications in revenue management. In game theoretic context, we establish three types of models to solve the hotel room inventory control problem in three different situations: 1) two-player two-fare-class static single-period game with complete information; 2) two-player two-fare-class dynamic multiple-period game with complete information; and 3) two-player two-fare-class single-period game with incomplete information.

 In the first situation, we find the existence of unique Nash equilibrium and Stackelberg equilibrium in the non-cooperative case. We provide the exact forms for these equilibria and corresponding conditions. Next, under the dynamic game settings, we provide the sufficient conditions for the unique Nash equilibrium. In the last situation, we consider the static single-period games with incomplete information and discuss the optimal strategies for the uninformed case, secret information case, private information case and public information case. The unique Bayesian Nash equilibrium in each case is found. We then analyze the values of different types of information and study their relations in different situations. Under each game theoretic setting, we present the managerial implications of our solutions along with the numerical examples. The thesis is concluded by a discussion of how game theory can is useful in hotel industry, and its relationship to other topics in revenue management.

abstract: Thesis

abstract: Doctor of Philosophy (PhD)


title: Characterization and Explanation of the Destination Choice Patterns of Canadian Male Labour Force Entrants 1971-76

contributor:
Liaw, Kao-Lee
Geography

subject: characterization, explanation, choice patterns, destination, Canadian, male labour, force, migration model

abstract:
 Since the classic study of migration and metropolitan growth by Lowry (1966), migration researchers have assumed a two-stage process wherein the decision to migrate is followed by the destination choice decision. Such an approach is employed here, to provide a characterization and explanation of the destination choice patterns of the male labour force entrants.

 Specifically, a nonlinear migration model, developed by Liaw and Bartels (1982), is applied to Canadian migration data for the 1971-76 period. The inter-metropolitan
migration patterns of the male labour force entrants is found to be well explained by six explanatory variables: population size, logarithmic distance, housing growth, employment
increase, cultural barriers and "strong ties". The last two variables are dummy variables derived from the characterization of the destination choice patterns through the application of entropies. The study examines factors involved in the destination choice decision and concludes with suggestions for future investigation.

abstract: Thesis

abstract: Candidate in Philosophy


contributor:
Siddall, J.N.
Mechanical Engineering

abstract: Title: A Study of Optimization Techniques and Their Applications to Design, Author: Mir W. Wahed, Location: Thode

abstract:
This thesis consists of a general survey of existing mathematical
optimization techniques and of an attempt to apply such techniques to
various design situations. Several analytical and numerical techniques
of determining extrema of univariable and multivariable known or unknown
functions subjected to equality and inequality constraints are investigated
when such extrema lie either in the interior or on the boundary
of a given region. Design examples are worked out to illustrate the
applicability and the limitations of the methods and the procedure of
attacking a problem for solution. Some of these applications are
original with the author. An extensive survey of applications of
optimization techniques to several design situations is also included.
No such design orientated survey seems to have ever been taken. Comments,
regarding the applicability of these techniques to various design situations
and suggestions for further research are made.

abstract: Thesis

abstract: Master of Engineering (ME)


title: An Analysis of the Ontario Waste Management Corporation's Site Selection Procedure

contributor:
Anderson, W.
Geography

subject: Ontario Waste Management, site selection, procedure

abstract:
Abstract Not Provided.
Thesis
Candidate in Philosophy


contributor:
Thode, H.G.
Chemistry

abstract: Title: The Design of a Heated Mass Spectrometer Ion Source for Isotope Abundance Measurements, Author: Robert H. Mills, Location: Thode

abstract: A simple furnace type mass spectrometer positive ion source has been designed constructed and tested. This source operated satisfactorily under certain conditions and was used in the determination of the relative abundances of the copper isotopes.

abstract: Thesis

abstract: Master of Science (MS)


title: A Computer Aided Study of the Film Loop in the Rolling Loop Projector

contributor:
Newcombe, W. R.
Mechanical Design

subject: computer, film loop, rolling, projector, clamping planes, coplanar

abstract:
 A review of movie projection principles and techniques as applied to conventional projectors and a description of general features, mechanism and film movement of the Rolling Loop Projector are presented.

 The characteristics of a film loop under static conditions with coplanar clamping planes are investigated in terms of loop shape, supporting forces and bending moments. An extension of this analysis is applicable to the case when the loop is fixed on a curved surface.

 The motion of a loop in the projector is simulated
as it grows and rolls on a flat surface and a numerical technique is employed to find the point paths and the velocity and acceleration vectors of these points on the loop at various instants in a projection cycle.

 Some design criteria are derived from an examination of the results, and these are presented.

abstract: Thesis

abstract: Master of Engineering (MEngr)


contributor:
Shaw, D.M.
Geology

abstract: Title: Petrology and Geochemistry of Some Early Tertiary Lavas of the Okanagan Lake Region, South Central British Columbia, Author: Robert J. Mepham, Location: Thode

abstract:
A petrological and geochemical study has been carried
out on some early Tertiary lavas of the Okanagan Lake region of
south-central British Columbia. Included are a discussion on
stratigraphy and petrographic descriptions, along with some
chemical investigations of the rocks and a discussion concerning
the general problem of petrogenesis. Analytical methods used
are explained, and a discussion of the results is included.

abstract: Thesis

abstract: Bachelor of Science (BSc)


contributor:
Pirdy, G.R.
Metallurgy

abstract: Title: Effect of Solid State Diffusion on Microsegregation in Steels, Author: Dipak B. Moharil, Location: Thode

abstract:
Controlled solidification of Fe-2wt% Ni binary and Fe-2 wt% Ni-Xwt%C ternary alloys was carried out in a travelling furnace. Metallographic studies were used to observe the effect of carbon on the morphology of growth. Electron probe microanalysis was carried out to obtain
quantitative results on the microsegregation of Ni in the binary and ternary alloys. The extent of homogenization of Ni, occurring both during and after solidification was quantitatively estimated.

abstract: Thesis

abstract: Master of Engineering (ME)