identifier: Mittal, Rakesh <https://research.library.mun.ca/view/creator_az/Mittal=3ARakesh=3A=3A.html>   (1993) Molecular mechanisms of glucocorticoid-dependent oncogenesis and expression of human papillomavirus type 16 DNA.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Human papillomaviruses have been implicated as a causative agent in the etiology of many human cancers, especially cervical carcinomas. Our laboratory had previously shown that the presence of the steroid hormones, dexamethasone and progesterone, markedly enhances the transformation of primary rodent cells by HPV type 16 DNA in cooperation with the EJ-ras oncogene. This enhancement could have been direct, through a previously known glucocorticoid response element (GRE) located at nt position 7640 in the transcriptional regulatory region of the HPV 16 genome. Two additional GRE-like sequences were also found at nt positions 7385 and 7474. Alternatively, indirect mechanisms could be conceived through hormone-mediated expression of other cellular transcription factors which in turn modulate HPV gene expression. To address the role of the GRE located at nt position 7640, site-directed mutational analysis was performed. In transformation assays in cultured rodent cells and in transient CAT assays with the human cervical carcinoma cell line, HeLa, I found that loss-of-function mutations of this GRE retained the response to dexamethasone, indicating involvement of other factors. However, converting this GRE into the consensus sequence resulted in an increased frequency of transformation and a greatly increased expression in transient assays, indicating the role of this GRE also. Retention of a hormone response for the loss-of-function mutations led me to examine the role of the other two GRE-like sequences in transformation and gene expression. A series of single, double and triple mutants, containing different combinations of mutations in the three GREs, were tested in transformation and transient gene expression assays. The results showed that all three elements are individually functional and are required to observe any hormone effect in both assays. The two newly identified GREs were further characterized using synthetic oligonucleotides. Both GRE sequences were studied for their ability to respond to dexamethasone in transient CAT assays. In addition, specific DNA protein interactions were examined using several in vitro DNA-protein interaction assays. Results have shown that both GRE sequences respond to dexamethasone and bind specifically to a protein of 97 kDa, the molecular size of the native glucocorticoid receptor. -- As the GRE at nt position 7640 is a composite GRE with an overlapping AP-1 motif, that interacts with the cellular c-jun and c-fos transcription factors, the role of these cellular oncogenes in glucocorticoid-dependent expression of HPV 16 genes was also examined. The results demonstrated that c-jun conferred a positive response of dexamethasone-induced expression of viral genes, whereas, presence of c-fos inhibited this response. Interestingly, the composite GRE was responsive to dexamethasone only in the presence of c-jun, indicating the special significance of the composite GRE in HPV gene regulation. -- To examine if the GREs are functional in the principle host tissue for HPV 16 infection, primary human ectocervical cells were cultured and used to examine the effects of hormones on HPV 16 gene transcription. Viral RNA was examined using in situ hybridization, after transfecting either wild type or mutated HPV genomes into these cells. Viral transcription was observed for the wild type HPV genome only in the presence of these hormones and could be blocked by RU486, an anti-progestin, in a dose-dependent fashion. Constructs with all single or double GRE mutations also responded to both hormones, whereas, a triple mutated construct, with all three GREs disrupted did not support any detectable induction of viral transcription. Thus, steroid hormones appear to be essential for episomal expression of HPV genes in primary human cervical cells. This result also emphasizes the role of hormones in early stages of HPV infection where the majority of HPV DNA is found episomally.


identifier: Mlewa, Chrisestom Mwatete <https://research.library.mun.ca/view/creator_az/Mlewa=3AChrisestom_Mwatete=3A=3A.html>   (2003) Biology of the African lungfish Protopterus aethiopicus Heckel 1851, and some aspects of its fishery in Lake Baringo, Kenya.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

type: Thesis NonPeerReviewed

abstract: The introduction of the marbled lungfish (Protopterus aethiopicus) into Lake Baringo created a new fishery. This study describes the life history characteristics and movements of this population, and provides baseline biological information for more rational exploitation and management of its fishery. Biological data were obtained from fishery landings, while movement and space use were studied using ultrasonic telemetry. -- Biological data indicate Lake Baringo lungfish grow allometrically, individual growth in length was about 14.5 cm year ⁻¹. Males mature later than females, but are less abundant in open waters, likely because they spend more time in inshore spawning areas. Spawning occurs year-round, probably related to the lack of a predictable rainy season in Lake Baringo. Internal differentiation of the digestive tract was apparent contrary to previous reports. Their diet in Lake Baringo is primarily piscivorous. -- Ultrasonic telemetry showed lungfish are not sluggish, but rather make nonrandom daily movements (likely in search of prey) in the open waters and were active at night as well as in the day. Their movements consisted of: 1) shorter daily movements over several weeks or months, followed by 2) a series of successive longer daily movements over a few days, and there was evidence of navigational ability. Sonically tagged lungfish ranged widely but tended to avoid shallow inshore waters where crocodiles are abundant. However, some had home ranges of varying size (5.8 - 19.8 km²) and which were occupied for 2 - 4.5 months. Ultrasonic-tagged fish were always relocated in the lake, however, one radio-tagged lungfish was caught in a swamp upstream on the Molo River about 4.5 months after release, indicating lungfish can and do migrate out of the lake. -- Radio telemetry results suggested that P. aethiopicus are not obligate air breathers. Aerial respiration is necessary, however, during stress situations and this probably explains the death of most lungfish caught on long-lines. Attaching hooks to long leaders will allow hooked fish to access the surface and increase live lungfish landings, which earn more income. Maintenance of a viable lungfish fishery in Lake Baringo depends on protection and conservation of shallow inshore riparian areas and control of illegal fishing practices.


identifier: Moetariyono, R. Didiek <https://research.library.mun.ca/view/creator_az/Moetariyono=3AR=2E_Didiek=3A=3A.html>   (1992) Sediment budget and estuarine circulation on the Brantas River Estuary, East-Java, Indonesia.  Masters thesis, Memorial University of Newfoundland.

abstract: The Brantas River with a catchment area of 12,000 sq km is the largest river in Eastern Java, Indonesia. Heavy monsoon rains create flooding and the sediment load is enhanced by fine volcanic ashes from Kelud Mountain, located in the middle of the drainage basin. Flood controls were placed on the river to minimize excessive floods. Every year large quantities of sediment enter the estuary. Some settles within the estuary, particularly the deltaic region, but a significant portion flushes directly to the surf zone bordering the Madura strait. Much of the material is redistributed in estuary areas as the fresh water flow subsides. – Topographical changes caused by this sediment load became more significant after a manmade channel, the shortcut channel, was dredged to bypass the existing delta. – Field measurements and collation of existing data were carried out during the dry season of 1991. Data were collected relating to tides, sediments, waves, currents, topographical changes and fresh water discharge with a view to understanding sediment movement and budget in the estuary and any chronological sequences. Theoretical analyses were also conducted to evaluate sediment inflow by tidal and longshore currents, river mouth processes and delta growth. – The study has shown that significant changes have taken place, that the processes are ongoing and that the discharge capacity of the two main channels is decreasing. One specific aspect of the study shows that since the dredged shortcut channel has been completed, the major delta growth has moved from the original river mouth to that of the shortcut channel. Consequently, new geometric formations of the surf zone have been developed. Now, the shortcut channel has become a main channel while the original river becomes shallower and narrower year by year. – Sedimentation in the estuary is an important aspect of flood and sediment management on the Brantas River. Further work is required to adequately determine the sediment budget and estuarine circulation to permit development in the Brantas estuary.


identifier: Haja Mohideen, Asan Meera Sahbi <https://research.library.mun.ca/view/creator_az/Haja_Mohideen=3AAsan_Meera_Sahbi=3A=3A.html>   (2013) Analysis of variations in hypoxia-pathway genes and mitochondrial DNA as prognostic markers in colorectal cancer patients.  Masters thesis, Memorial University of Newfoundland.

abstract: Colorectal cancer is a common malignancy, characterized by high incidence and mortality rates. Hypoxia induces angiogenesis, metastasis and aggressive tumour phenotype and hence promotes cancer progression. Similarly, dysfunctions in mitochondria have been shown to contribute to cancer progression. Therefore, in this thesis, genetic markers in both the hypoxia pathway genes and the mitochondrial DNA are hypothesized to be candidate genetic prognostic markers in colorectal cancer. -- The aim of this study is to test genetic markers that can predict outcome in colorectal cancer patients. This study consists of two projects: 1) the mitochondrial DNA variations project and 2) the hypoxia pathway Single Nucleotide Polymorphisms (SNPs) project. In the mitochondrial DNA (mtDNA) variations project, six mtDNA polymorphisms and the mtDNA copy number change were tested for their prognostic associations. However, none of the mtDNA markers selected was found to be associated with outcome. The hypoxia pathway SNPs project was done in two phases. In the first phase, 49 tagging SNPs from six hypoxia genes (HIF1A, HIF1B, HIF2A, LOX, MIF and CXCL12) were genotyped in a cohort of 272 colorectal cancer patients (cohort I). In the second phase, 77 tagging SNPs from seven hypoxia genes (HIF1A, HIF1B, HIF2A, HIF2B, HIF3A, LOX and CXCL12) were genotyped in a separate cohort of 536 colorectal cancer patients (cohort II). -- In phase I, the TT and AT genotypes of the HIF2A rs11125070 polymorphism was associated with increased disease free survival (DFS) in the multivariable model (p=0.004; HR=0.619; 95% CI: 0.446-0.859). In phase II, patients with TC and CC genotypes for the HIF2A rs4953352 polymorphism and patients with the GG genotype for the HIF2B rs12593988 polymorphism were associated with both reduced overall survival (OS) and DFS in multivariate models. However, the association of the HIF2A rs11125070 polymorphism with DFS detected in the phase I cohort was not replicated in the phase II patient cohort, suggesting this association was possibly a false-positive association. Similarly, association of the HIF2A rs4953352 polymorphism with OS and DFS detected in the phase II cohort failed to be detected in the phase I patient cohort, which may be due to the small sample size of cohort I. Association of the HIF2B rs12593988 polymorphism remains to be tested in another colorectal cancer cohort. -- In conclusion, this study shows no evidence of associations between majority of genetic markers in hypoxia pathway genes and mtDNA with prognosis in colorectal cancer. However, whether or not the HIF2B rs12593988 polymorphism is associated with prognosis needs to be confirmed by investigating other patient cohorts.


identifier: Mohidin, Sharifah <https://research.library.mun.ca/view/creator_az/Mohidin=3ASharifah=3A=3A.html>   (2006) A phenomenological study: the lived experience of women with breast cancer who are receiving adjuvant therapy.  Masters thesis, Memorial University of Newfoundland.

abstract: Understanding women's experiences with breast cancer and adjuvant therapy is important for nurses in order to help these women deal with a number of important issues that are related to their condition and treatment. There is a growing literature on women's breast cancer experiences, but most of these studies have been done from the perspective of women living in western societies and the findings may not be appropriate to women living in Malaysia. The purpose of this study was to obtain a deeper understanding of the experience of women who are living with breast cancer and who have undergone adjuvant therapy, focusing particularly on changes in the life perspective of these women in Malaya. Using Giorgi's phenomenological method six Malaysian women who had survived breast cancer and had received adjuvant therapy were interviewed in-depth. Through data analysis seven themes were identified. These themes were: 1) Not knowing what to do; 2) The meaning of a diagnosis of breast cancer; 3) Suffering through the treatment; 4) The changing body; 5) Trying to protect others; 6) Finding strength and making changes; and 7) The importance of support. The findings are similar to other research that has been done in this area, but suggests the concern these breast cancer survivors have for others, especially close family members, may prevent them from seeking earlier diagnosis and treatment. The findings also indicate the importance of cultural beliefs on women's experiences with breast cancer. The research has implications for how nursing practice and education is carried out in Malaysia. A number of areas are recommended for further research.


identifier: Monajemi, Mahdis <https://research.library.mun.ca/view/creator_az/Monajemi=3AMahdis=3A=3A.html>   (2012) Novel role of APOBEC3G/F enzymes in adaptive immunity.  Masters thesis, Memorial University of Newfoundland.

abstract: Human immunodeficiency virus (HIV) utilizes our immune system to replicate in the body while having developed ways to evade it. However, immune cells have intrinsic barriers against HIV. Apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC), most notably APOBEC3G (A3G) and APOBEC3F (A3F) are cytidine deaminases that act by mutating deoxycytidine (dC) to deoxyuridine (dU) in the(-) strand DNA that is generated upon reverse transcription of the viral genome. A3G/F are constitutively expressed pre-infection with HIV and act non-specifically throughout the viral DNA. For these reasons, they are considered anti-viral host restriction agents that participate in the initial innate immune response against HIV. Adaptive immunity is a more specific immune response that carries an immunological memory, and in the case of HIV, consists of anti-viral antibodies as well as cytotoxic CDS+ T cells (CTL). Here, we hypothesize that beyond A3G/F role in innate immunity within infected cells, mutations by A3G/F modulate HIV recognition by the adaptive immune system through modifying peptide epitopes recognized by CTL. To test our hypothesis, we I) identified all CTL epitopes restricted to each human leukocyte antigen (HLA) in silica, 2) identified the CTL epitopes and A3G/F hotspots therein that are mutable by A3G/F and simulated mutations in them, 3) measured the CTL responses of HLA-matched, HIV-infected individuals to peptides containing A3G/F mutations ex vivo, and 4) analyzed the frequencies of A3G/F hotspot motifs inside and outside of the CTL epitopes in silica. Our results reveal for the first time that rather than being beneficial for the adaptive immune system, mutations of the HIV genome by A3G/F may have the opposite effect by assisting HIV to escape from CTL responses. Furthermore, we show that the HIV genome has adapted to position A3G/F hotspot motifs selectively in CTL epitopes to maximally subvert the action of A3G/F towards immune escape.


identifier: Montes, Patricia <https://research.library.mun.ca/view/creator_az/Montes=3APatricia=3A=3A.html>   (2004) L'Espagne camusienne.  Masters thesis, Memorial University of Newfoundland.

title: L'Espagne camusienne

abstract: L’ascendance espagnole d'Albert Camus- tirée du côté de sa mère - est présente dans l’oeuvre de l'écrivain algérien. Dans ce mémoire, je me propose d'examiner Ia manière dont l'Espagne imprègne I'oeuvre camusienne. Mon corpus est constitué des deux pièces de théâtre de Camus qu'il à situées en Espagne, ses essais qui manifestent les sentiments de Camus sur Ia culture espagnole et ses adaptations de deux pièces de l’Age d'Or espagnol -La dévotion à la croix de Calderón de la Barca et Le chevalier d'Olmedo de Lope de Vega. -- Révolte dans les Asturies est caractérisée par I’accent que met Camus sur les valeurs humaines. Elles sont manifestées par I'altruisme des ouvriers qui sacrifient volontiers leur vie pour Iutter contre l'injustice. Malgré l'échec, leur fraternié, leur fidélité et leur courage continuent car la solidarité se perpétue parmi les citoyens après la révolte. Bien que Camus expose la violence de l'armée et des mineurs, il est clair que ce sont la force et la grandeur qu'il identifie au peuple espagnol. -- Camus introduit le thème de l'abondance de la terre espagnole dans cette pièce avec le personnage d'Alonso. Celui-ci exprime sa nostalgie de son village natal, du soleil et des produits de la terre. L'idéalisation camusienne de l'Espagne trouve done son origine dans les valeurs humaines manifestées par les ouvriers d'Oviedo et dans le thème de l'abondance dans Révolte dans les Asturies. -- La célébration des valeurs humaines qu'on vient de signaler dans Révolte dans les Asturies s'intensifie dans l'état de siège. Diego guérit ses concitoyens de la peste en appelant à Ia justice et en reconnaissant la force et Ia dignité humaines. Son engagement personnel dans Ia lutte contre La Peste, son appel à la solidarité et l'héroïsme qu'il démontre en se sacrifiant pour sauver  Cadix découlent de sa foi dans la grandeur innée de l'homme. -- La notion de I'abondance de la terre revient dans des images hautement euphorisées de l'Espagne. Dans leur nostalgie de l'Espagne perdue, Le Choeur se souvient de l'abondance de l'été espagnol et de l’opulence de sa récolte. L'appel à Ia mer et au vent guérissants renforce le lien entre I'homme et son milieu. -- Le fil de l’idéalisation camusienne de l'Espagne devient une glorification du pays, du peuple et de Ia culture dans les essais et les adaptations - La dévotion à la croix et Le chevalier d'Olmedo. Ses essais exaltent ouvertement la fidele et loyale amitié de ses "frères espagnols" et son admiration pour Ia culture espagnole- surtout pour le théâtre du Siecle d'Or - est sans bomes. Les buts avoués de ses adaptations de Caldéron de la Barca et de Lope de Vega sont de transmettre à Ia jeunesse, Ia passion de vivre et l’esprit de grandeur du théâtre espagnol pour faire renaitre le théâtre désillusioné. Le terme "esprit de grandeur" que le dramaturge emploie pour décrire le théâtre espagnol correspond à Ia grandeur de I'homme qui anime Ia révolte de Diego. -- La notion embellie de l'Espagne chez Camus arrive à son point culminant lorsqu'il célèbre l'harmonie entre le corps de l'homme méditerranéen et la volupté du monde qu'il habite. La fusion géographique, historique et culturelle entre l'Espagne et I'Algérie - entre l'Occident et l'Orient- est, pour l'écrivain algérien, sa "religion" basée sur le monde sensuel. Le soleil et la mer - toute Ia volupté du monde physique de l'Algérie- se mêlent à Ia lumière eta l'abandon de l'été espagnol. Tout ce que Camus admire dans l'Espagne sont des échos de ce qu'il apprécie déjà dans son pays natal. Ainsi son culte de l'Espagne se transforme-t-il en culte méditerranéen.


identifier: Montevecchi, Gioia Lorraine <https://research.library.mun.ca/view/creator_az/Montevecchi=3AGioia_Lorraine=3A=3A.html>   (2012) Factors influencing access to health care services in Labrador: a case study of two distinct regions.  Masters thesis, Memorial University of Newfoundland.

abstract: This research explores the factors that influence access to health care services and addresses strategies for improvement in two distinct regions of Labrador. This qualitative project employed an interpretive epistemology and case study methodology. The environmental scan and interview analysis outlined the major challenges accessing health care and strategies to overcome them from the perspective of local healthcare administrators, providers, and community members. The findings identified thirteen factors that create challenges accessing health care associated with the physical environment, socio-cultural and political environment, gender, and continuity and comprehensiveness of care. These factors were considered in light of factors that influence access to health care in other rural regions of Canada. Despite the complexities encompassed within these factors, participants identified seven strategies to overcome the challenges accessing health care services, notably: Tele-health, bringing services to communities, recruitment and retention strategies, the Medical Transportation Assistance Program, navigation tools, the scheduled evacuation system, and the medical evacuation system.


identifier: Moore, Eric J. <https://research.library.mun.ca/view/creator_az/Moore=3AEric_J=2E=3A=3A.html>   (1971) Pontryagin multiplication and a relation with the Whitehead product.  Masters thesis, Memorial University of Newfoundland.

abstract: The space Ω of loops over a 1-connected space X possesses a natural multiplication, namely the composition of loops. This multiplication induces a Pontryagin product in homology, while the properties of the multiplication induce, in homology, the structure of an associative algebra with identity. -- The first three chapters of this thesis are introductory: The first describes the concept of cubic homology, the second, spectral sequences, and the third, the spectral sequence of a fiber space. -- In Chapter 4, the Pontryagin product is defined for P, a path space over a 1-connected space X. Since P is well known to be a fiber space over X with fiber Ω, the results of the previous chapters may be used to determine certain properties of the Pontryagin product in P these results are summarized by Theorem (4.45). -- Finally in Chapters 5 and 6, the two main theorems are presented and proven in complete detail. Theorem A, due to Bott and Samelson, determines the Pontryagin algebra of the loop space Ω, where the elements of the homology groups of X are transgressive (in the spectral sequence of P), and its corollaries determine the Pontryagin algebra of the loop space over a sphere, the loop space over the one point union of spheres, and the loop space over the suspension of a 0-connected space. Theorem B, due to Samelson, gives a relationship between the Whitehead and the Pontryagin products. Two proofs are given for Theorem B : the first establishes the relationship up to a factor of ±1, the second determines the sign. -- Both Theorem B and the second corollary of Theorem A are valuable in the determination of the homotopy groups of the one point union of spheres.


identifier: Moore, S. J. <https://research.library.mun.ca/view/creator_az/Moore=3AS=2E_J=2E=3A=3A.html>   (2003) The clinical and genetic epidemiology of Laurence-Moon-Bardet-Biedl syndrome in Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: Background -- Bardet-Biedl Syndrome (BBS) and Laurence-Moon Syndrome (LMS) are differentiated by the presence of spasticity and the absence of polydactyly in LMS. The aims of this study were to determine whether BBS and LMS are the same disorder, describe the clinical and genetic epidemiology and examine genotype-phenotype relationships.  -- Methods -- A population-based, prospective study was conducted. 46 patients from 26 families were enrolled. Patients and relatives were genotyped at BBS loci. Longitudinal and cross-sectional clinical data were analysed. -- Results -- There were at least six BBS genes in the cohort. Characteristic craniofacial dysmorphic features were identified. Neurological manifestations were prevalent. 2/46 patients were diagnosed clinically as LMS but both had mutations in a BBS gene. Major clinical outcomes were similar for all genotypes. – Conclusions -- LMS and BBS are the same disorder. It is associated with a characteristic craniofacial dysmorphology and abnormalities in almost every organ system. The widespread systemic involvement and lack of a genotype-phenotype correlation implies that the BBS genes are involved in the same early developmental pathway.


identifier: Moorehead, Paul C. <https://research.library.mun.ca/view/creator_az/Moorehead=3APaul_C=2E=3A=3A.html>   (2013) Clinical and laboratory variables associated with clinically significant bleeding in pediatric intensive care unit patients.  Masters thesis, Memorial University of Newfoundland.

abstract: Existing research into clinically significant bleeding in Pediatric Intensive Care Unit (PICU) patients is limited to specific bleeding sites and specific patient groups. Existing literature does not accurately describe the epidemiology of clinically significant bleeding in the PICU and may not correctly identify potential risk markers. Using a broadly inclusive definition of clinically significant bleeding, we conducted a retrospective cohort study of PICU patients and identified clinical risk markers including mechanical ventilation, antibiotic and antacid medications, performance of multiple procedures, and cardiac surgery. A threshold for platelet count associated with clinically significant bleeding in PICU patients was also identified, but other common laboratory tests of hemostasis had no association. We designed a prospective observational cohort study to further examine the association of laboratory tests with clinically significant bleeding. Platelet count was again associated with clinically significant bleeding, but the International Normalized Ratio (INR) and the activated Partial Thromboplastin Time (PTT) were not. This association was present even after adjustment for potentially confounding clinical variables. These results suggest that thrombocytopenia is an important and potentially modifiable risk factor for clinical significant bleeding in PICU patients.


identifier: Moores, Justin Nathaniel <https://research.library.mun.ca/view/creator_az/Moores=3AJustin_Nathaniel=3A=3A.html>   (2007) Analysis of Huntingtin-interacting protein 1 in Drosophila melanogaster.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Huntington's disease (HD) is associated with a wide range of effects including selective neuronal death and altered levels of neurogenesis that are ultimately dependent upon altered activities of Huntingtin (Htt) interacting proteins. These effects are similar in nature to those observed with mutations in the Notch signal transduction pathway. Huntingtin interacting protein 1 (Hip1) shows decreased binding to expanded Htt. Hip1 plays a key role in endocytosis and intracellular transport and activation of the Notch signal requires both. Based on this observation links between Hip1 and Notch-dependent neurogenesis were investigated. In Drosophila two hip1 mRNAs may be naturally produced through the use of alternative splicing of the first exon: full length hip1 with lipid binding ANTH domain and hip1ΔANTH lacking this domain. Directed expression of hip1 decreases while expression of hip1ΔANTH increases microchaetae density in the dorsal notum, a field of sensory bristles on the fruit fly back, suggesting a functional role for Hip1 in neurogenesis. The following studies demonstrate genetic interaction between hip1 and deltex, a key mediator of Notch signaling, with hip1 enhancing and hip1ΔANTH suppressing deltex phenotypes. Reduction of bristle microchaetae density associated with NotchMCD alleles is sensitive to hip1 and hip1ΔANTH. This pathway is shown to be independent of classical Notch control through E(sp1) and tightly controlled by both GSK3β and achaete levels. Building on this the possibility of an analogous pathway in human neuronal development was investigated using the Ntera-2/D1 neuronal precursor cell line along with siRNA and antibody technologies. These studies demonstrate that the Hip1 functions in a similar deltex-dependent, HES1-independent process of neuronal differentiation. Hip1's novel role in neurogenesis provides a functional link between Notch signaling and proteins related to HD advancing the understanding of HD neurogenic phenotypes. -- During the course of these investigations it was noted by others in our laboratory that high levels of Ga/4 in the developing eye result in elevated apoptosis in the eye imaginal disc. Suppression of apoptosis by expression of the caspase inhibitor p35 prevented this phenotype. These studies were extended to analyze Gal4 phenotypes associated with microchaetae density using the pannier-Ga/4 transgenic line. The reduction in microchaetae density associated with pannier-Ga/4 is suppressed by co-expression of p35 but unaffected by expression of GFP. These results show that Gal4 has effects outside the Drosophila eye and that similar mechanisms of disruption are at work at least in the eye and dorsal notum.


identifier: Moores, Lisa Connor <https://research.library.mun.ca/view/creator_az/Moores=3ALisa_Connor=3A=3A.html>   (2013) Come from away, far away: the lived experience of international students in a predominantly homogeneous host culture.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: International students face a variety of challenges and triumphs over the course of their cross-cultural transitions. While a body of literature has investigated these experiences within the context of large and culturally diverse urban centres, little research has examined cross-cultural transitions in host sites that lack such diversity and resources. This paper explores the lived experience of nine international students in a small urban centre with a relatively homogeneous host culture that has not traditionally been a receiving site for international newcomers. Purposeful sampling was employed to assemble a diverse group of international undergraduate and graduate students and two in-depth individual interviews were conducted with each participant. An empirical phenomenological methodology (Colaizzi, 1978) was utilized to provide a rich description of the lived experiences of these participants as they crossed cultures. A total of 516 significant statements regarding experiences deemed important, hindering, or facilitative by the participants were extracted from individual interview transcripts. Participant checks, during which participant feedback on authenticity of findings was invited, were completed at the individual and group levels. Eight thematic clusters emerged from this data: (a) Influence of Host Environmental Context, (b) Influence of Academic Context, (c) Process of Cross-Cultural Transition, (d) Language Challenges, (e) Supportive Relationships, (f) Meeting Across Cultures, (g) lntrapersonal Factors, and (h) Personal Significance. Thirty-one themes were found within these clusters. Major findings discussed include endorsement of an immersion strategy toward acculturation, proactive and creative means of connecting with the host community, the importance of positive experiences with locals as a facilitative factor, the personal transition accompanying cross-cultural transition, heavy academic workloads as a barrier to availing of support services, a dearth of international perspective within the host curriculum and academic environment, and an indication that international student participants at the host location may not be true sojourners (temporary residents for study purposes), but fall into a pre-immigrant category. A consideration of how this research fits with studies of international student transition in larger centres, implications for postsecondary institutions and the mental health services that support these academic sojourners, in addition to future research directions, are provided.


identifier: Moreau, Darek T. R. <https://research.library.mun.ca/view/creator_az/Moreau=3ADarek_T=2E_R=2E=3A=3A.html>   (2011) Potential for ecological effects and gene flow resulting from growth hormone transgenic Atlantic salmon (Salmo salar) interactions with wild conspecifics.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Growth hormone (GH) transgenic Atlantic salmon (Salmo salar) exhibit tremendous growth rates under hatchery conditions. This phenotypic response has created interest within the aquaculture industry; however, possible escapee events have raised concerns regarding their potential ecological impacts. This thesis applied an eco-evolutionary approach to empirically assess the potential ecological effects of GH transgenic Atlantic salmon on non-transgenic intraspecific populations. Specifically, my goal was to explore the relative survival and reproductive success of GH transgenic and non-transgenic salmon under near-natural conditions. To accomplish this, key fitness-related traits were compared between GH transgenic and non-transgenic Atlantic salmon over periods of their life cycle when natural selection is typically intense. Specifically, this thesis focused on the young-of-the-year stream and the breeding periods. -- Two studies (Chapters 2 and 3) compared fitness-related traits between transgenic and non-transgenic Atlantic salmon during early life history. Chapter two explored the potential differences in developmental rate and respiratory metabolism between transgenic and non-transgenic siblings at three early stages of life; the eyed-embryo, alevin (larval) and first-feeding fry (juvenile) stages. Chapter three explored the foraging behaviour and the growth and survival of transgenic and non-transgenic first-feeding fry reared under low feed, stream-like conditions. Collectively, the result of these chapters suggest that there is an ontogenetic delay in the phenotypic response induced by the transgene, such that biologically significant differences in fitness-related traits between GH transgenic and non-transgenic Atlantic salmon are minimal during this critical early life history period. -- The final two studies (Chapters 4 and 5) compared fitness-related traits between transgenic and non-transgenic Atlantic salmon during the reproductive phase of the life cycle. The fourth chapter compared the breeding performance of growth hormone transgenic and non-transgenic Atlantic salmon males of both alternative reproductive phenotypes to test for the potential of the transgene to introgress into wild populations. The fifth chapter used populations of GH transgenic and non-transgenic Atlantic salmon siblings to elucidate the effects of growth on precocious parr maturation. Collectively, these data suggest that transgenic males may experience reduced reproductive success relative to non-transgenic individuals. However, the potential for the transgene to introgress into wild populations was demonstrated. The empirical contributions of this thesis inform decisions regarding the potential ecological impacts associated with GH transgenic Atlantic salmon.


identifier: Moreira, Manuel F. <https://research.library.mun.ca/view/creator_az/Moreira=3AManuel_F=2E=3A=3A.html>   (2007) Mapping spaces and fibrewise homotopy theory.  Masters thesis, Memorial University of Newfoundland.

abstract: If q : Y → B is a fibration and Z is a space, then the free range mapping space Y!Z has a collection of partial maps from Y to Z as underlying set, namely those maps whose domains are individual fibres of q. -- It is shown in [B3] that these maps have applications to several topics in homotopy theory. Three results [B3, Ths. 5.1, 6.1 and 7.1], concerning identifications, cofibrations and sectioned fibrations, are given in complete detail. The necessary topological foundations for two more complicated applications, to the cohomology of fibrations and the classification of Moore-Postnikov systems, are also given. The applications themselves are outlined in Chapters 8 and 9 of [B3]. -- The argument of [B3] is in the context of the usual category of all topological spaces, and this necessarily introduces some limitations. Whenever we work with exponential laws for mapping spaces in that category, we usually find that we are forced to assume that some of the spaces are locally compact and Hausdorff. These conditions detract considerably from the generality of the results obtained. -- In this thesis we develop the aforementioned topological foundations in the category of compactly generated or CG-spaces, which is free of the inconvenient assumptions mentioned above. Furthermore we do not require the Hausdorff condition for CG-ification as in [S]. Thus we obtain the CG-space versions of the applications to identifications, cofibrations and sectioned fibrations, a theorem on infinite CW-complexes, and establish improved foundations for the CG-versions of the other two applications, i.e. the cohomology of fibrations and the classification theorem for Moore-Postnikov factorizations.


identifier: Morgan, David, 1953- <https://research.library.mun.ca/view/creator_az/Morgan=3ADavid,_1953-=3A=3A.html>   (1980) Paleomagnetism of tillites on the Avalon Peninsula, Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: Please see thesis for abstract.


identifier: Morneau, Jean Philippe <https://research.library.mun.ca/view/creator_az/Morneau=3AJean_Philippe=3A=3A.html>   (1997) Trace metal analysis of marine zooplankton from Conception Bay, Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: Stripping Voltammetry has been used in the determination of the concentration, speciation, and for toxicity studies of trace metals in the marine environment. Anodic Stripping Voltammetry (ASV) and Cathodic Stripping Voltammetry (CSV) are two highly sensitive techniques that have frequently been used in the study of trace elements at environmental (or trace) concentrations in both water, sediment, and biota. Due to the information that may be obtained through the use of stripping voltammetry, the cycling and fate of trace elements may be determined. The determination of the speciation of metals provides knowledge of what forms are present in the water column. Upon use of stripping voltammetric analysis it is determined what ASV- and CSV-labile concentrations of metals, such as Zn, Cd, Pb, and Cu are present in sea water. This information is extremely valuable since it correlates with most of the dissolved fraction, that is the free ionic and weakly bound (both organic and inorganic), in sea water which is believed to be the bioavailable fraction. An ASV method was developed for the analysis of zooplankton for Zn, Cd., Pb, and Cu which could be used to study the cycling of trace metals in the Labrador Current.


identifier: Morris, Corey John <https://research.library.mun.ca/view/creator_az/Morris=3ACorey_John=3A=3A.html>   (2013) Population connectivity and its application to marine protected area effectiveness in a sub-Arctic coastal ecosystem.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Atlantic cod (Gadus morhua) in Gilbert Bay provides an opportunity to better understand the potential effectiveness of a Marine Protected Area (MPA) in providing protection for a specific population, including the roles that oceanography and behaviour may play in population connectivity. This thesis uses long-term monitoring and research (1998-2011) through mark-recapture tagging, oceanographic sampling, ichthyoplankton tows, and acoustic telemetry tracking to describe demographic trends and population connectivity of the Gilbert Bay Atlantic cod population in southeastern Labrador, Canada. The population declined considerably after Gilbert Bay became a MPA, presumably as a direct result of legal fishing activities outside MPA boundaries. Therefore connectivity research was undertaken to investigate population dynamics and infer strategies to Improve MPA effectiveness. The locally adapted timing and location of spawning strongly influences the population's localized connectivity, resulting in egg retention at the spawning area. Tagging showed high site fidelity in juvenile and adult cod and that migratory adults exhibit strong homing behavior. Migratory adults move up to 40 km rom the population's core area, but return to that core area to overwinter and spawn. Transplant experiments demonstrated the importance of prior experience for successful homing. Fish displaced outside their known or assumed home range displayed very low homing success compared to those displaced to areas within their home range. Adolescent and adult Atlantic cod migrated briefly from the head of the bay towards coastal areas for summer feeding, which increased susceptibility to fishing in areas outside the MPA. However, most ultrasonically tagged fish moved less than 10 km outside MPA boundaries. This new information on the timing and locations of fish movement can improve MPA effectiveness by identifying times and locations when a portion of the protected population moves away from the MPA and becomes vulnerable. Such knowledge can facilitate adaptive management and improved co-operation between MPA stakeholders and fisheries managers.


identifier: Morris, Richard Joseph <https://research.library.mun.ca/view/creator_az/Morris=3ARichard_Joseph=3A=3A.html>   (1988) "Confidentiality in social work", the professional secret or the profession's secret?: a study of social workers' knowledge of and attitudes toward confidentiality.  Masters thesis, Memorial University of Newfoundland.

abstract: While some research about confidentiality in social work has been undertaken, this study is believed to be the first which explores what social workers actually know about confidentiality Eighty-seven social workers in St. John’s, Newfoundland, responded to a questionnaire designed to measure their ability to discern violations of confidentiality in hypothetical situations. – The results of the study indicate that the social workers studied had deficits in their knowledge about confidentiality. Further, the respondents displayed overconfidence about their knowledge, being significantly more confident than they were correct. The evidence demonstrates a positive relationship between education and ability to make correct decisions with regard to the vignettes. – The major concern emanating from this study is that in balancing the right of the individual to privacy with often competing societal interests, social workers make unnecessary errors on both sides because they lack existing knowledge to guide their decision-making. The results have negative implications for the social worker – client relationship in terms of trust, and the development of the profession itself as relates to ethics. This is of particular relevance in Canada, where the profession of social work is attempting to assert its status with some vigor. The results of this study are a pointed indication of the need for better training in the principles underlying confidentiality and their application in practice. It is only with improved knowledge of confidentiality that the social work profession’s secret, namely, that little is clearly understood by many social workers about confidentiality, can be transformed to its desired status of the professional secret so as to protect the interests of individuals and of society.


identifier: Morris-Jenkins, Melanie <https://research.library.mun.ca/view/creator_az/Morris-Jenkins=3AMelanie=3A=3A.html>   (2003) Fishers' and scientists' social-ecological knowledge and Newfoundland's capelin fisheries.  Masters thesis, Memorial University of Newfoundland.

abstract: Using a case study of the Newfoundland capelin fisheries, this thesis explores the potential benefits of a social-ecological approach to gathering fishers' knowledge, analyzing both fishers' and scientists' knowledge, and attempting to integrate insights from both knowledge forms. In doing so, the thesis employs data from two types of personal interviews with fishers, as well as findings from scientific studies, to highlight points of both agreement and disagreement between fishers and scientists on four major issues that were forefront in the Newfoundland capelin fishery in the 1990s. Using a social-ecological approach to knowledge, possible reasons are posed to understand why scientists and fishers disagree with each other and why some fishers disagree with others. -- The thesis demonstrates that this approach to understanding fishers' and scientists' knowledge is essential for projects that aim to critically assess and effectively integrate insights from these different sources. The thesis also sheds light on areas of scientific research that may require further research and analysis and proposes a series of policy recommendations that may strengthen future collaborative efforts that aim to integrate fishers' and fisheries scientists' knowledge.


identifier: Morrow, Gregory P. <https://research.library.mun.ca/view/creator_az/Morrow=3AGregory_P=2E=3A=3A.html>   (2012) Formate metabolism in the rat.  Masters thesis, Memorial University of Newfoundland.

title: Formate metabolism in the rat

abstract: The folate-associated one-carbon (1C) metabolic pathways provide the building blocks for key components of DNA (thymidylate and purines), as well as the supply of methyl groups for methyltransferases. The free formate pool plays an essential role in the transport of one-carbon units from production to utilization. An enzymatic assay was optimized for the determination of the plasma formate concentration in rats under normal and folate-deficient conditions. Stable isotope tracer infusions were used to quantify the endogenous production rates of formate; this amounted to 75 μmol/hr /100 g body weight in folate-replete rats, dropping to 45 μmol/hr /100 g body weight in folate-deficient rats. This means that, in (healthy) folate-replete rats, endogenous formate production accounts for -35% of the total ingested potential 1C groups (44% of that remaining after accounting for net protein synthesis). This could indicate that formate production is a central component of the metabolism of some of these 1C precursors. We investigated the importance of known dietary 1C precursors to the 1C pool through a dietary precursor supplementation study. Serine, histidine, and choline were found to be significant precursors to formate.


identifier: Morton, Kathryn E. <https://research.library.mun.ca/view/creator_az/Morton=3AKathryn_E=2E=3A=3A.html>   (2011) Development of larval fish: a multi-species perspective.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: This thesis progresses from the previous examinations of finfish early life history by first examining the differences and similarities of larval fish development among species, and then building on this knowledge base to test for species similarities based on phylogeny and/or ecology. The first analysis undertaken was a corroboration of external characteristics with internal characteristics (Chapter 2). Second, a detailed analysis of lipids in larval fish across multiple species was completed (Chapter 3). The third analysis chapter (Chapter 4) examines the interplay among developmental processes within larval fish, and how these tradeoffs vary between species. The fifth chapter further extends this question and utilises variation amongst individuals to determine which of these processes are optimised to produce larvae that survive. In the final analytical chapter (Chapter 6), all of this information is incorporated into an exploratory multispecies model. -- The contribution of this thesis in its entirety to the field of marine fish ecology is in three general areas: 1) the relevance of body size to larval fish; 2) the potential applicability of a multispecies model of larval fish development; and 3) sources of larval fish mortality. Research within this thesis favoured the use of mass to determine internal state of a larval fish, although to allow comparison across studies, reporting of both mass and length continues to be the most effective approach. Explicitly explaining the similarities and differences observed among species was not assisted by the use of phylogenetic analysis, but ecological patterns such as demersal or pelagic life cycle phases, and season of hatch were somewhat more successful. Additional information about sources of larval fish mortality resulted from highlighting the importance of variables that characterise developmental events during ontogeny (i.e. development progress variables, Chapters 4 and 6) and through the analysis of patterns of intrinsic selection (Chapter 5).


identifier: Mouland, Darrell <https://research.library.mun.ca/view/creator_az/Mouland=3ADarrell=3A=3A.html>   (2005) Semi-automated characterization of thin-section petrographic images.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis represents the continuation of work on PetrograFX, an automated image analysis toolkit for petrographic image analysis. These types of images are used in the petroleum industry to provide valuable information, however, the retrieval of data from these images is time consuming and prone to operator bias. An integrated solution that combines a number of basic image processing concepts, each tailored towards segmenting a particular type of grain, is developed to automate this process. Specifically, an attempt is made to replicate the methodology and analysis carried out by core laboratories, which typically place more emphasis on overall 'interpretation of the image rather than just the measurement of the porosity and quartz grain distribution. This requires a solid treatment of the geological background to ensure the data being collected will be useful. Due to their complex nature there will be regions within these images that are unidentifiable. This approach necessitates a classification routine to eliminate objects once they have been segmented to ensure that they are unaffected by subsequent routines. To provide a quick and objective assessment segmentation performance an automated accuracy routine is presented.


identifier: Mouland, Derek J. <https://research.library.mun.ca/view/creator_az/Mouland=3ADerek_J=2E=3A=3A.html>   (2003) A study of algal biofouling on pearl nets in Charles Arm, Notre Dame Bay, Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: This study examined the development of biofouling on pearl nets used for culture of the sea-scallop (Placopecten magellanicus) in Charles Arm, Notre Dame Bay, Newfoundland over a two year period, May 1998 until July 2000. The site showed salinities of approximately 30 ISU and surface seasonal temperature fluctuation between  -1.5C and 20C. The greatest part of the fouling biomass consisted of macroalgae : Chlorophyta (10 species), Phaeophyta (24 species), Rhodophyta (19 species), together with Cyanobacteria (33 species) and two species of tube dwelling diatoms. All the species recorded were common members of the local benthic flora. Fouling biomass was measured on nets placed at two, and four metre depths. Rapid colonization occurred with growth initially faster at the shallow depth, but after the first year biomass stabilized at approximately I kg per net wet weight, with no significant differences between depths. The fouling community was analyzed using two multivariate techniques, Detrended Correspondence Analysis (DECORANA) and Two-Way Indicator Species Analysis (TWINSPAN). The first year's growth showed considerable floristic changes as the algal fouling developed, with samples from the latter part of the year showing considerable differences from the late spring and early summer. After one years growth few floristic changes were noted. There was no obvious difference in the algal communities between the two depths. -- Two algal grazers, the periwinkle, Littorina littorea and the green sea urchin Strongylocentrotus droebachiensis were investigated as potential biofouling control organisms. Two experiments were conducted, one in the summer months and one over winter. The pearl nets with the urchin treatment showed no significant decrease in fouling, while the periwinkle treatments significantly reduced fouling in the summer. DECORANA and TWINSPAN analysis showed no differences in algal community structure between the experiments and controls, showing that grazing was not species preferential. -- During the course of this study there was a large, and as yet still unexplained, die-off of the cultured scallops at the site, which confounded attempts to determine if the inclusion of algal grazers in the nets affected growth and survival of the scallops. These preliminary studies, however, showed no differences in the growth rate of the scallops with depth, or treatment with snails or urchins. Survival of the scallops was, however, significantly enhanced by the snail treatment in both experiments including enhanced survival in the summer experiment, when scallop loss was greatest.


identifier: Mounier, Robert Alan <https://research.library.mun.ca/view/creator_az/Mounier=3ARobert_Alan=3A=3A.html>   (2008) The aboriginal exploitation of Cuesta Quartzite in Southern New Jersey.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: This thesis explores the aboriginal exploitation of Cuesta quartzite in southern New Jersey. The stone is an orthoquartzite, a silica-cemented quartzite that was formed at or near the earth's surface. The geological distribution of this material coincides with the Cuesta, the geomorphological ridge that separates the Inner and Outer Coastal Plains of New Jersey. Cuesta quartzite takes its name from this association. Although the material is very difficult to knap, it was extensively used in prehistory, principally for stemmed and notched bifaces, but also for hammerstones. Repetitive heat-treatment improves its flaking qualities and enabled ancient knappers to work the stone according to a staged sequence of bifacial reduction. When used as hammerstones, Cuesta quartzite was also repeatedly heated, with the apparent goal of modifying its toughness so as to customize the hammers to the stone being worked. In addition to affecting its toughness, heating the stone tends to redden it, to add luster, and to cause the entrapped quartz grains to sparkle, all of which had probable symbolic significance. The research employed experiments to gauge the effects of heat on the stone. Four skilled experimental knappers also flaked matched pairs of bifaces-consisting of one heated and one unheated specimen - to evaluate the knapping characteristics before and after thermal alteration. In all cases, the knappers reported improvement in the ease of flaking after heating. X-ray fluorescence analysis and laser ablation microprobe-inductively coupled plasma mass-spectrometry establish the geochemical composition of the material. The quartzite consists chiefly of silica with a host of other minerals and trace elements. The petrological analysis does not permit linking archaeological specimens to particular geological deposits. A battery of radiocarbon dates places the utilization of Cuesta quartzite between 6600 and 1600 B.P. Using the chaîne opératoire approach as its theoretical basis, this thesis integrates archaeological data and experimental results to reconstruct the aboriginal technology associated with the use of Cuesta quartzite during the period of its efflorescence. The analysis leads to the conclusion that both the ascendancy and decline of Cuesta quartzite as a lithic resource were fundamentally economic adaptations to a changing landscape. This thesis further highlights the benefits of collections research, archaeological investigations in the field of cultural resource management, and replicative experimentation. The work marks an advance in knowledge respecting a widely used but heretofore little studied lithic material.


identifier: Mudalige, Wasana A. K. A. <https://research.library.mun.ca/view/creator_az/Mudalige=3AWasana_A=2E_K=2E_A=2E=3A=3A.html>   (2007) Structure function of actin and tropomyosin isoforms and discovery of a unique actin isoform.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: 1. Tropomyosin [TM] was isolated from following sources; shark fast skeletal muscle, which contains a single, partially phosphorylated, alpha type isoform, and salmonid fast, slow and cardiac muscle. At 50mM ionic strength [pH 7.0, room temperature], thin filaments composed of shark phosphorylated TM produce a higher steady-state activation of the myosin-S1MgATPase compared to those containing the unphosphorylated protein. This difference is attributable to the extra negative charge associated with phosphoserine 283 which, under certain conditions [neutral pH, low ionic strength], enhances the interaction of adjoining TM molecule. By comparison, none of the salmonid TMs are unphosphorylated. Of the substitutions, which are distributed throughout the molecule, one occurs within the overlap region [Asn276 in fast, His in slow and cardiac]. This correlates with observed weakening of the end-to-end association of the C-terminal histidine-containing isoforms [cardiac and slow] relative to one present in fast muscle (1). Surprisingly, however, thin filament activation of myosinS1MgATPase increases in the order: fast TM < slow TM < cardiac TM. Since thin filaments composed of cardiac TM generate the greatest amount of activation it is apparent that tightness of the joint site is not the sole determinant for regulation. Thin filament based regulation is also sensitive to substitutions within the internal region of tropomyosin. The results of myosin binding show very little difference in the affinity of myosin for thin filaments containing non-identical isoforms of tropomyosin. Therefore these data suggest that the observed changes in steady state rate are due to a change in a kinetic step in the actomyosin ATPase cycle. -- 2. Unlike other vertebrates, salmonids synthesize a unique isoform of actin in each type of striated muscle [fast, slow and cardiac]. Two are virtually identical to each other but one [slow actin] is divergent and is inferred to contain six or seven non-conservative substitutions depending on the pairing [out of a total of twelve] when compared to the other salmonid actins and rabbit actin. Four of these replacements are predicted to occur in sub-domain 3. The other two or three are in sub-domain 1. Of particular interest is the substitution at residue 360, where a neutrally charged amino acid in a variety of isoactins is replaced by Asp in slow actin. This is consistent with the observation that slow actin migrates ahead of other isoactins when analysed by alkaline urea PAGE. Of all actins tested, the one from slow muscle is the least conformationally stable G-actin [calcium form + ATP], as gauged by a number of techniques including electronic circular dichroism. The midpoint of the change in far-UV ellipticity versus temperature for this isoform is 10°C lower than that of other actins studied [transition temperature, 45°C versus 55°C]. The slow isoform also displays a reduced rate of polymerisation, a faster rate of nucleotide dissociation and a lower level of myosin activation. These data suggest that actin heterogeneity is a source of thin filament diversity in some vertebrate skeletal muscle. -- 3. A survey was conducted to determine the distribution of slow muscle actin throughout the animal kingdom. Skeletal muscle actin extracted from certain species, selected on the basis of their taxonomical position, was characterized. Of the species surveyed, a unique isoform was identified in slow muscle of Chondrichthyes [mako shark] and Osteichthyes [teleosts, salmon, Atlantic herring and tuna] but not amphibians [frog] and avians [chicken]. In the latter two cases, the same isoform is present in both types of skeletal muscles. Further, a slow muscle actin gene is absent from the genomes of puffer fish and human. This suggests that a slow muscle actin gene starts to express randomly and then stops expressing after short period of time. This appearance and disappearance is a unique feature, which has occurred during the course of evolution in other genes as well. According to phylogenetic tree analyses performed using several methods [neighbour-joining, minimum evolution and MrBayes method] for selected amino acid and nucleotide sequences, a close relationship between salmon slow muscle actin and puffer fish cardiac actin which is considered one of the oldest actins, was observed. Finally, an actin clone was isolated from a dogfish shark skeletal muscle cDNA library and sequenced. The nucleotide sequence clusters with that chicken actin, which again underlines the extraordinary degree to which the protein has been conserved.


identifier: Mudde, Anna <https://research.library.mun.ca/view/creator_az/Mudde=3AAnna=3A=3A.html>   (2004) The justice of the pieces: liberalism, democracy, and the globalization of the nation-state.  Masters thesis, Memorial University of Newfoundland.

abstract:
For Carl Schmitt, sovereign rule and the nature of sovereign power are conceptions of
what makes a state political. The sovereign nation is legitimated by its conceptualized (or
real) democratic foundation, but is maintained by the absolutist nature of its sovereign
power. Similarly, Hobbesian sovereignty presupposes the notion of state as that body by
which sovereign power governs. I argue that the international community is formulated
on a Hobbesian conception of nation-state sovereignty, which embodies a contradiction:
the political value of nations as (state) individuals, and the liberal value of a common
humanity. This contradiction is mirrored in the tension that exists within the state
between democracy and liberalism, and is central to Western international political theory
and policy. The validity of Hobbesian-based conceptions of nation-state sovereignty are
being pulled into question. Nation-states, I argue, are increasingly required to use the
sovereign decision in order to justify their sovereignty, as defined by the 'nation'. I
attempt to show why the present international system, as a contributor to the forces of
liberal globalization, naturally leads us to question state sovereignty, which ensures the
continued use of violent sovereign power.


identifier: Muggeridge, Karen Julie <https://research.library.mun.ca/view/creator_az/Muggeridge=3AKaren_Julie=3A=3A.html>   (1994) Investigation of control strategies and development of a hydraulic actuator mechanism for accurate positioning of subsea robots.  Masters thesis, Memorial University of Newfoundland.

abstract: Subsea robot control must be robust in the face of dynamic uncertainties encountered in the unstructured ocean environment. In this thesis, the main control strategies are examined and evaluated in terms of their potential for underwater robot control. It is concluded that robust control would be achieved with a mix of supervisory and classical control strategies. In particular, neural networks and fuzzy logic combined with error-driven compensation are recommended for high performance underwater control. -- A new propulsion device for short duration fine-positioning control of small subsea robots is proposed. This device uses a hydraulic actuator mechanism operated from an energy source of compressed gas to mimic the jet propulsion of squids. Experimental work conducted demonstrated the potential of the proposed propulsion device.


identifier: Mugo, Samuel Mutuura <https://research.library.mun.ca/view/creator_az/Mugo=3ASamuel_Mutuura=3A=3A.html>   (2007) Humic substances studies and new approaches to analysis of small molecules by MALDI-TOFMS.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Humic substances (HS) are complex natural materials that are thought to be produced by decomposition of biogenic matter. HS are known to be involved in various processes such as amending soil fertility, metal chelation and sequestration of organic contaminants; they also are precursors of harmful water disinfection byproducts (DBPs). To understand the role of HS in all these processes it is imperative to understand their structural features. A MALDI-TOF MS method has been developed to characterize these materials and the results showed clear evidence of the oligomeric nature of HS. However, the inherent complexity of HS demands a multi pronged approach, thus thermally assisted hydrolysis-methylation-GC-MS was employed to aid in elucidating possible structural constituents of HS. Thermochemolysis results demonstrated a strong similarity between natural organic matter standard and humic acid model synthesized from polymerization of 4-oxo-2-butenoic acid, derived from oxidation of furfural, a well known product of dehydration of polysaccharides. These results suggest the concept that polysaccharides are important precursors in HS formation. -- Studies of DBPs resulting from chlorination and chloramination of HS were also carried out. Based on our understanding of key structural features of HS and rigorous mass spectral analysis, haloketones were found to be one of the major classes of DBPs formed and numerous other potentially new DBPs were also identified. Their formation was replicated using selected plant flavanoids as model compounds for HS. Most of the resulting DBPs were polar, thermally labile and of high molecular weight and hence not amenable to analysis by the standard technique, GC-MS. To circumvent these problems, we have developed a new, rapid, selective, quantitative and very sensitive (detection limits in the sub parts per billion range) "reactive matrix"-LDI MS method fix the analysis of carbonyl and α-dicarbonyl compounds. These techniques can be extended to the analysis of carbonyl compounds of importance in other fields: e.g., metabolomics, clinical diagnostics, food science, etc. Finally with good understanding of the structural properties of HS obtained from our studies, aquatic fulvic acid has been demonstrated as a novel universal MALDI matrix.


identifier: Muir, Christopher Alan <https://research.library.mun.ca/view/creator_az/Muir=3AChristopher_Alan=3A=3A.html>   (2007) Stress-activated hormonal response following predator stress mediates the precipitation of long lasting changes in affective behavior in rats.  Masters thesis, Memorial University of Newfoundland.

abstract: The role of β-adrenoreceptors, glucocorticoid receptors (GRs), and mineralocorticoid receptors (MRs) in the consolidation of changes in anxiety-like behavior following predator stress were studied by injecting specific receptor blockers 1 minute after the stress event and testing for behavior change in a battery of tests 1 week later. Propranolol dose dependently blocked stress effects in all behavior tests except startle. GR block (RU486) alone was ineffective, but in combination with low dose propranolol blocked stress-induced anxiety-like behavior in all tests. Surprisingly, MR block (spironolactone) also prevented the consolidation of anxiety-like behavior in all tests except the light-dark box. -- Startle results were complicated by the presence of both stress-induced increases and decreases in peak startle amplitude. Treatment with chlordiazepoxide and RU486 effectively blocked startle suppression, but not enhancement, indicating that the consolidation of these two memory processes may be mediated by different mechanisms. In contrast, when administered in combination with propranolol, RU486 prevented stress-induced startle enhancement, as did MR block using spironolactone. -- Predator stress delayed habituation to startle in all rats. This was blocked by post-stress treatment of spironolactone, chlordiazepoxide, and RU486 + propranolol in combination, but not by RU486 or propranolol given alone. -- Present findings indicate that consolidation of predator stress-effects share neurochemical mechanisms in common with fear conditioning models, and are relevant to the study of stress-induced changes in affect in humans.


identifier: Mulcahy, Barbara L. <https://research.library.mun.ca/view/creator_az/Mulcahy=3ABarbara_L=2E=3A=3A.html>   (2012) The evolution of settlement services and educational programs offered by the association for new Canadians: 1979 to 2011.  Masters thesis, Memorial University of Newfoundland.

abstract: Research on immigrants and refugees in Canada has focused mainly on immigration, immigration policy, and settlement sector developments, with a dearth of studies on settlement service agencies. This study focused on the genesis and evolution of one service provider in Newfoundland and Labrador. The purpose of this research was to explore the efforts of this organization to assist with settlement and integration. Three aspects of settlement were explored: settlement services, language education, and labour market integration. This qualitative research used a case study methodology. Data was generated through data analysis and semi-structured interviews. The study provides information about and insight into an organization that has not been previously documented or fully recognized. It also forefronts considerations for the provision of ongoing and future programs and services. This research has important considerations for similar organizations, as well as for policymakers, educators and researchers.


identifier: Mulrooney, Rhoda <https://research.library.mun.ca/view/creator_az/Mulrooney=3ARhoda=3A=3A.html>   (2001) A study into the need for a bullying/harassment program at St. Stephen's High School, Stephenville, Newfoundland, Canada: a school psychology internship report.  Masters thesis, Memorial University of Newfoundland.

abstract: The internship for the Master of Education (Educational Psychology) at Memorial University, St. John's, Newfoundland, Canada was completed at St. Stephen's High School in Stephenville, Newfoundland. The report consists of a placement component, which includes the intern's goals and objectives; and the internship experiences (activities and learning). -- A research component studied the perceptions of bullying and harassment among students at St. Stephen's High School. A questionnaire developed by a school team of teachers and students was administered to four hundred and thirty-eight students. Results indicated that bullying is a significant problem at the school and that the implementation of an anti-bullying program should be considered to help reduce bullying. This information will be useful for many schools and school boards for future planning and the delivery of anti-bullying programs. Limitations of the research are also discussed.


identifier: Munasinghe, Dona Lalani Lekha <https://research.library.mun.ca/view/creator_az/Munasinghe=3ADona_Lalani_Lekha=3A=3A.html>   (2013) Protein synthesis in mucin-producing tissues is conserved when dietary threonine is limiting.  Masters thesis, Memorial University of Newfoundland.

abstract: Mucins in mucus are particularly rich in an indispensable amino acid, threonine, and their continuous synthesis and secretion represent a major use of dietary threonine. In piglets, the small intestine is particularly sensitive to a low threonine intake resulting in compromised mucin production. Other epithelial tissues also synthesize large amounts of mucin but their impact on threonine requirement is not as well known. Yucatan mini-piglets were fed test diets with different threonine intakes and various tissues were analyzed for protein synthesis. The threonine intake at which maximal protein synthesis was reached was lower for mucin-producing tissues, suggesting mucin-producing tissues are conserved when dietary threonine is limiting, compared to muscle, liver and kidney. So if neonates are on a marginal threonine intake, then growth and the functions of other vital tissues are likely compromised at the expense of maintenance of the mucus layer.


identifier: Munawar, Iram <https://research.library.mun.ca/view/creator_az/Munawar=3AIram=3A=3A.html>   (2004) Structural and magnetic phase transitions in hexagonal perovskites.  Masters thesis, Memorial University of Newfoundland.

abstract: Please see thesis for abstract.


identifier: Munden, Jenna G. <https://research.library.mun.ca/view/creator_az/Munden=3AJenna_G=2E=3A=3A.html>   (2013) Reducing negative ecological impacts of capture fisheries through gear modification.  Masters thesis, Memorial University of Newfoundland.

abstract: Capture fisheries provide the world with a healthy source of protein than can have minimal environmental impacts if harvested sustainably. Negative environmental impacts of capture fisheries include; overexploitation, modification of food webs, mortality of nontarget species, habitat alteration and biodiversity loss. A mitigation technique often used to reduce ecological impacts of fishing without compromising commercial catches is gear modification. This thesis explores modification of two gear types; shrimp trawl and turbot longline. Modifications were made to shrimp trawl footgear to reduce habitat alteration and to turbot longline gear to reduce Greenland shark bycatch. Testing of modified with traditional gears demonstrated that the modified gears with reduced ecological impacts did not negatively affect commercial catches. The 200 lb monofilament gangion is recommended for commercial testing by turbot longline fishers in Cumberland Sound; however the aligned shrimp trawl requires further modifications due to unexpected increases in turbot bycatch compared to the traditional trawl.


identifier: Munier, Anne <https://research.library.mun.ca/view/creator_az/Munier=3AAnne=3A=3A.html>   (2006) Seedling establishment and climate change: the potential for forest displacement of alpine tundra (Mealy Mountains, Labrador, Canada).  Masters thesis, Memorial University of Newfoundland.

abstract: Loss of alpine habitat is of concern due to upslope migration of altitudinal treelines in response to climate change. The possibility of a rise in the tree-line of the Mealy Mountains of Labrador (Canada) was investigated by planting tree seeds and seedlings (Picea mariana, Abies balsamea, and Betula papyrifera) into experimental treatments along an elevational gradient in the tree-line ecotone. Treatments included passive warming with open top chambers; ground disturbance, and herbivore exclosures. Responses in seedling emergence, growth, damage sustained and mortality were monitored over one (A. balsamea, B. papyrifera) or two (P. mariana) growing seasons. Planted seedlings were able to establish and over-winter above present tree-line, but none were observed growing naturally. A lack of viable seeds may be limiting current tree-line migration, though seed viability improves with climate warming. While seedbed conditions and herbivory may eventually control the rate of seedling establishment, the results point to a strong possibility that tree-lines in the Mealy Mountains are capable of migrating upslope, with potentially significant changes or losses to the existing alpine habitat.


identifier: Murphy, A. Mary <https://research.library.mun.ca/view/creator_az/Murphy=3AA=2E_Mary=3A=3A.html>   (2003) The theory and practice of life writing: a group biography of Adele, Craig, Laura, Henrietta, Lucy, and Mary Pierce 1915-1940.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Personal histories, public events, geographic location, and cultural forces interact at the level of family and community to make group biography legitimate as both literary and historical work. My work constructs the lives of a family; its greatest significance is its inscription on Canadian history and culture of women whose stories have not been told outside their family and of a man whose public story has not been told within the context of his family life. A. Craig Pierce is a significant figure in Alberta agriculture, through farming practice and participation in the Progressive movement between the World Wars. My work seeks to place him in the midst of his family-his wife Adele, and their daughters Laura, Hetty, Lucy, and Mary-and is undertaken in an attempt to resist the inclination of group biography to grant a constant centrality to one member of the group; instead, I incorporate a shifting focus appropriate to an ensemble cast in an attempt to shape each of the women as a rounded character of equal importance to the man in the house. Through reading a variety of verbal and non-verbal texts, including journals, letters, photographs, and needlework, I give a material existence to a specific familial past at the: same time that I delineate the individual entities within the symbiosis of family. -- This experiment in the theory and practice of life writing opens with a theoretical and anecdotal framework for use by life writers, tracing a project from conception to conclusion and considering the involvement of the writer in the process by including my self-reflexive participation in the text. It then provides a temporal and spatial setting, followed by an exploration of  the project's primary documentary source, before it progresses to shaping the lives of its subjects. Educational and family background, including birth order, are given lengthy consideration in these segments. Finally, six appendices supplement the project: a physical description of A. Craig Pierce's journals; a transcription of the 1919 journal; a reproduction of selected journal pages; family tree charts; an exercise in the analysis of material possessions as text; and the ethics protocol and consent form for the project.


identifier: Murphy, Madonna <https://research.library.mun.ca/view/creator_az/Murphy=3AMadonna=3A=3A.html>   (2007) The adequacy of vitamin E and vitamin C intakes by residents of Newfoundland and Labrador and its possible relationship to diabetes status: secondary analysis of data collected by the Nutrition Newfoundland and Labrador survey.  Masters thesis, Memorial University of Newfoundland.

abstract: This study is a secondary analysis of data collected by ‘Nutrition Newfoundland and Labrador’. Its primary goal was to estimate the adequacy of total vitamin E and total vitamin C intakes, by residents of this province. A secondary goal of this study was to look for a possible relationship between dietary intakes and diabetes status. Participants included 1927 non-institutionalized residents aged 18-74 years for the vitamin C analysis and 1181 participants for the Vitamin E analysis. The results suggest 82.3% of residents are not consuming enough total vitamin E to meet their estimated needs. Considering intake of total vitamin C, 48.3% of male non-smokers, 45.3% of female non-smokers, 78.8% of male smokers and 73.6% of female smokers have inadequate intakes. The intake of no nutrient studied was found to be associated with diabetes status. Residents of the province should be encouraged to consume diets of higher micronutrient density.


identifier: Murphy, Philip A. <https://research.library.mun.ca/view/creator_az/Murphy=3APhilip_A=2E=3A=3A.html>   (2005) Changes in perforant path: dentate gyrus evoked potentials during classical fear conditioning in the anesthetized rat.  Masters thesis, Memorial University of Newfoundland.

abstract: Neural changes accompanying fear conditioning in the hippocampus, specifically the dentate gyrus, have been described in awake rats. Doyere et al. (1995) examined the time course of synaptic modifications in perforant path-dentate gyrus connections during learning. They found an increase in slope (m V /ms) of the field excitatatory synaptic potential (EPSP), a reflection of system drive, for the conditioned group while a decrease was noted for the pseudoconditioned group. As for the reactivity of the granule cells in the dentate gyrus, population spike decreases were found in both groups. The primary goal of this study was to apply the conditioning methods of Doyere et al. (1995) and measure the perforant path-dentate gyrus responses during an anesthetized state using urethane. -- Following a 30 min initial baseline period, animals in the conditioned group received 32 tone-footshock pairings over a 90 min conditioning period, followed by a 60 min rest period, and then a 90 min extinction period during which 32 tones were presented. Mean EPSP slope and population spike responses were plotted over time and compared to the responses recorded in a pseudoconditioned group where animals received 32 deliberate CS-US unpairings during the 90 min conditioning period. -- The EPSP slope responses in both groups did not vary significantly from baseline level over the 300 min period and were not affected by the manner in which tone and footshock presentations were received. As for the population spike response, no group differences were noted during the conditioning period but a significant group by block interaction was found for the 60 min post-conditioning period. In contrast to the slope responses, significant group effects were found in the extinction period and the final 30 min period of recording. Consistent results were noted following analysis of the calculated ratios of the population spike/slope responses. Correlation analyses of the slope and population spike suggested that conditioning led to an increase in cell excitability such that a smaller slope was associated with a larger population spike. This effect occurred after conditioning and disappeared with extinction. -- The overall pattern suggested that  conditioning changes perforant path-dentate gyrus connections in the urethane anesthetized rat and that the changes are unlike those that occur during the awake state. While EPSP slope changes were non significant in both pseudoconditioned and conditioned rats, the difference in spike amplitude profile with conditioning relative to pseudoconditioning implies that pairing-related modifications can occur in the anesthetized state.


identifier: Murphy, Phoebe <https://research.library.mun.ca/view/creator_az/Murphy=3APhoebe=3A=3A.html>   (2011) The southern component of the Labrador Inuit communal house phase: the analysis of an 18th century Inuit house at Huntingdon Island 5 (FkBg-3).  Masters thesis, Memorial University of Newfoundland.

abstract: The focus of this thesis research is the excavation of a Labrador Inuit winter house occupied during the 18th century. The 18th century in Labrador was the period in which permanent European settlement began and intensifying Inuit-European and inter-Inuit trade networks developed. Furthermore, in the 18th century the Labrador Inuit began to construct large multi-family houses and this is referred to as the Communal house phase. This research concerns the excavation and analysis of an Inuit winter house at the Huntingdon Island 5 site (FkBg-3) in Sandwich Bay, southern Labrador. This excavation represents the first single component Labrador Inuit communal house to be investigated south of Groswater Bay, and consequently, contributes to the overall understanding of the Communal House phase and the distinct southern component of this period of Inuit history.


identifier: Murray, Anne F. <https://research.library.mun.ca/view/creator_az/Murray=3AAnne_F=2E=3A=3A.html>   (2004) Investigating the Professional Development Alliance: a study of an inter-agency education committee.  Masters thesis, Memorial University of Newfoundland.

abstract:
The Professional Development Alliance (PDA) is an alliance of educational organizations
in the province of Newfoundland and Labrador established to promote professional
development among educators. There is a need to explore the challenges faced by such
an inter-agency organization in achieving its objectives. The purpose of this thesis was to
investigate the formation of the PDA, the development of its model for teacher
professional development and the perceived supports and barriers to the implementation
process. A qualitative approach was used to gather data through interviews with each
member of the PDA committee. Interviews were taped, transcribed and analysed using
both inductive and deductive methods. Analysis of these interviews revealed how and
why the PDA was formed and how the PDA developed an inter-agency framework for
teacher professional development. Factors unique to Newfoundland and Labrador appear
to support inter-agency collaboration although barriers to implementing the PDA model
remain to be overcome. It is concluded that explicit identification and resolution of
potential difficulties needs to be part of the ongoing inter-agency process.


identifier: Murray, Brendan E. <https://research.library.mun.ca/view/creator_az/Murray=3ABrendan_E=2E=3A=3A.html>   (1981) A study investigating two hierarchical models relating to the attainment of the concept of momentum.  Masters thesis, Memorial University of Newfoundland.

abstract: The present study is concerned with a theoretical and empirical examination and extension of an earlier study by Raven (1967). Raven attempted to determine whether the concept of momentum followed a logical sequence, as determined from a logical analysis of the momentum concept, or a psychological sequence, as suggested by Piagetian research. The objections to Raven's study are threefold. Firstly, Raven based his hierarchy on only one task for each step in the hierarchy, with the exception of the concept of momentum where two tasks are used. Secondly, it is suggested that some of Raven's tasks do not test what is purported. Thirdly, Raven's results imply the superiority of a psychological as opposed to a logical model in the development of the momentum concept. It will be argued that Raven's logical hierarchy was inadequately developed and hence does not allow a meaningful conclusion, either with respect to the specific concept or to the relationship between psychological and logical hierarchies. -- The purpose of this study is to investigate Raven's (1967) claim that the development of the concept of momentum by young children follows a psychological rather than a logical progression. The psychological hierarchy involved is that used by Raven. The logical hierarchy is different from Raven's because of the investigator's belief that Raven's logical hierarchy was inadequately constructed, thereby biasing his findings. -- Data were obtained by the group-testing of 197 subjects from grades one to eight in a St. John's school. Two statistical tests, namely the White and Clark 'test of inclusion' and the 'ordering-theoretic' method, were used to analyse the data. The results of this analysis do not support Raven's contention that young children develop an understanding of the concept of momentum in accordance with a psychologically derived hierarchy, rather than a logical hierarchy. Instead, with little change, a logical hierarchy hypothesized by the present investigator is substantiated.


identifier: Murray, John James <https://research.library.mun.ca/view/creator_az/Murray=3AJohn_James=3A=3A.html>   (1984) The effects of wave grouping on the slow drift oscillations of floating moored structures.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: An original combined analytical and experimental study of the effects of wave grouping on the slow drift oscillations of floating moored structures has been presented. The work constitutes the first incorporation of existing techniques of simulating wave groups and the slow oscillating response of a moored model of a rectangular barge. The analytical model assumes that each pair of frequencies in a discrete wave spectrum will give rise to a regular wave group. Each of these regular wave groups will produce a low frequency force that is proportional to the product of the wave amplitudes in the ·group and varies at a frequency equal to the difference in the frequency pair. Furthermore, this low frequency force is related to a modified SIWEH of the regular wave group by a constant phase angle. Therefore the resultant force is determined by superposition of these regular slow-varying forces. Subsequently the ensuing slow oscillating motions can be established and related to the SIWEH spectrum. This relation is expressed in the form of a transfer function. The analytical model is then evaluated by means of a set of detailed experimental tests conducted on a rectangular barge. A JONSWAP spectrum was modelled for a range of grouping characteristics and the results compared to the analytical model. Results indicate that the slow drift motions are highly influenced by free motion effects. An empirical transfer function which included these free motion effects produced good agreement between subsequent predicted and measured slow drift responses. The technique developed in this study shows that the second-order response to linear waves can be related to the wave envelope when the effects of these linear waves are dominant.


identifier: Murray, Maribeth S. <https://research.library.mun.ca/view/creator_az/Murray=3AMaribeth_S=2E=3A=3A.html>   (1992) Beyond the laundry list: the analysis of faunal remains from a Dorset dwelling at Phillip's Garden (EeBi 1), Port au Choix, Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: The analysis of a large sample of faunal remains from a Middle Dorset semi-subterranean dwelling at the Phillip's Garden site (EeBi1), Port au Choix, Newfoundland, was undertaken. Results indicate that harp seal hunting was the focus of the Dorset occupation in this location. The age profile of the sample suggests that the dwelling from which the bone material was obtained was utilized in the early winter for the hunting of harp seals on their southward migration past the Point Riche peninsula to the Gulf of St. Lawrence. A detailed study of Phocidae body part representation within the dwelling suggests that complete seal carcasses were brought to the site and butchered. -- The study of refuse distribution and feature placement within the dwelling revealed a c-shaped activity zone located around the short-axis of the central depression. Refuse was deposited within two large pit features and along the back of a raised rear platform. This pattern of house organization is unique to Phillip's Garden and suggests that there is greater variability in Dorset house form and use of internal house space than previously thought. This variability may be a function of seasonally specific dwelling use.


identifier: Murrin, David <https://research.library.mun.ca/view/creator_az/Murrin=3ADavid=3A=3A.html>   (2007) A three-dimensional simulation of vortex induced vibrations (VIV) on marine risers at high Reynolds number using computational fluid dynamics.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The flow of seawater around marine risers is subject to vortex shedding which excites oscillations known as Vortex Induced Vibrations (VIV). When the VIV frequency approaches one of the natural frequencies of the structure, resonance occurs. This results in enhancement of the vibration amplitude of the structure and may have potentially destructive consequences. At present, the prediction of this phenomenon is one of the most challenging areas in the offshore industry. -- The focus of this research is on the development of a new approach for simulating vortex induced vibrations on marine risers at high Reynolds numbers using a Large Eddy Simulation (LES) computational fluid dynamics code. This method considers the span-wise variation of the lift and drag forces, and determines the moment acting on the cylinder. The predicted motion then consists of a rotational component to accompany the traditional cross-stream translation. -- A simulation of flow around a stationary cylinder was performed to establish the vortex shedding pattern and determine the lift and drag coefficients. At this point a harmonic model was invoked and the cylinder was free to respond to its shed vortices. Results are presented for the simulation of turbulent flows past a 3m long cylinder with 1m diameter, undergoing vortex induced vibrations at a Reynolds number equal to 1 x 10⁵.


identifier: Murrin, Michael Ronald <https://research.library.mun.ca/view/creator_az/Murrin=3AMichael_Ronald=3A=3A.html>   (2001) An examination of selected schools' experiences in implementing block scheduling.  Masters thesis, Memorial University of Newfoundland.

abstract: The aim of this study was to examine the various experiences of the administrators, teachers, and students with regard to the block scheduling experience at their school. In an effort to address anonymity and confidentiality the schools studied will be referred to as Cedar High and Woods High.  At the heart of the matter was the question of whether or not the block scheduling experience was a positive one. The study was qualitative in design and used the open-ended interview technique. In total there were 15 participants interviewed. – The participants interviewed in this study generally agreed that their experience with block scheduling as it existed at their school was a positive one. Post-secondary preparation, early graduation, and increased course options were given as contributing to the positive nature of their experiences.


identifier: Rahman, Md. Musfiqur <https://research.library.mun.ca/view/creator_az/Rahman=3AMd=2E_Musfiqur=3A=3A.html>   (2013) Input variable selection for multivariate statistical process monitoring.  Masters thesis, Memorial University of Newfoundland.

abstract: Multivariate statistical methods are widely used in process operations for predicting unmeasured quality, and detection and diagnosis of faults. Performance of these monitoring tools greatly depends on selecting the right set of variables as input to the tools. In a typical chemical process on average 1500 variables arc logged. Selection of appropriate input variables from these large set of variables is a daunting task. This thesis investigates the application of retrospective Taguchi method in selecting input variables for multivariate statistical monitoring tools. Taguchi's design of experiment (DoE) approach has been widely used in industrial process design, primarily in manufacturing industries for optimizing process parameters. Instead of relying on an arbitrary selection of levels, experiments are conducted following an orthogonal array as determined by the Taguchi method. In the current research, the method is adapted for selecting important input variables for process monitoring tools, namely, support vector regression (SVR) and principal component analysis (PCA). Taguchi's DoE assumes t hat variables are uncorrelated which is contrary to process data. Process variables are highly correlated and show dynamic variations due to the frequent change made in the set points causing difficulty to select data to match the orthogonal array of the Taguchi method. These implementation difficulties were addressed in the proposed methodology. Retrospective Taguchi method was adapted for dealing with process data. Additional data preprocessing and correlation analysis steps were proposed to condition process data for Taguchi method. Detailed methodologies to apply Taguchi method to select input variables for SVR and PCA are described in the thesis. The methodologies were demonstrated using industrial data from a petrochemical process and a hydrometallurgy process respectively. The performance of the proposed Taguchi based method was compared with variable importance in projection (VIP) method. The industrial case studies clearly show that the proposed methodology can minimize the computational efforts in variable selection and it can improve the performance of the monitoring tools.


identifier: Muzale, Henry R. T. <https://research.library.mun.ca/view/creator_az/Muzale=3AHenry_R=2E_T=2E=3A=3A.html>   (1998) A reconstruction of the proto-rutara tense/aspect system.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: This study begins by locating the Rutara subgroup in the major group of Lacustrine, and by showing its internal relationships, lexicostatistically, phonologically, lexically, and morphologically. All these show that Rutara is a coherent linguistic group that originates from one common ancestral language labelled as Proto-Rutara. Out of this have evolved most of the differences that distinguish its daughter languages today. Following the classification of Rutara languages, a basic description of the tense/aspect (T/A) systems for eight languages of the group is presented. The description takes a cognitive approach, partly stemming from Guillaume's concept of chronogenesis (which concerns the mental time image and stratification of the development of verbal systems from simple to more complex forms), in the light of historical and comparative linguistics. Thus, the description has two levels: first, the analysis of the basic meanings of various T/A formatives, from simple forms to complex and compound markers, which constitute various T/A systems in the eight sample languages studied and, second, a comparative study of these formatives and markers across the group. The analysis surveys and reveals both the basic as well as the extended functions of the formatives, from a morphosemantic, morphosyntactic, and cognitive point of view. Consequently, the study proposes the levels at which the development of T/A in the Rutara languages exists. -- From the cognitive point of view, the mechanisms behind the apparent asymmetry found, for instance, in the markers for Past and Future tenses, as well as in the Persistive and Progressive aspects are explained. Similarly, various cognitive and psychosemantic reasons for the innovation of different T/A markers, and reasons for combining simple formatives to create complex markers are also established. It is argued that these processes led to the mechanism of recycling and reassigning formatives in terms of their functions, alongside phonological, morphological and semantic changes in the system(s). These complex and recycled verbal systems have created a number of distinctive tenses and aspects, most of which are characterised by morphological syncretism. Finally, the Proto-Rutara T/A system is reconstructed. This study thus shows how different markers have developed diachronically into their contemporary forms.