identifier: Barhoum, Suliman Abdallah <https://research.library.mun.ca/view/creator_az/Barhoum=3ASuliman_Abdallah=3A=3A.html>   (2012) NMR studies of multi-component macromolecular solutions.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: My doctoral studies deals with model systems in soft matter. In these model systems, we address questions that are on the interface between physics and biology. The primary focus of the studies is to explore the dynamics and structural changes of aggregations of biologically relevant multi-component polymer, protein, peptide, and micellar systems using nuclear magnetic resonance (NMR) based techniques. Diffusometry, relaxometry, and deuterium NMR techniques were chosen since they complement one another in understanding the dynamics and structure in the process of macromolecular self-assembly. Moreover, identifying the size of nanoparticle clusters in these model systems is a challenging problem and there is no technique that gives complete answers . Therefore, my doctoral work is a systematic attempt to use NMR as a tool to make quantitative statements about the nature of macromolecular clustering. -- During my PhD, we used a model polymer-surfactant solution in order to identify surfactant concentration regimes relevant to understanding the behavior of biomolecules in a "crowded environment" consisting of multiple species of macromolecules. Such crowded environments are a characteristic of intracellular plasma . We studied a system composed of nonionic polymer poly(ethylene glycol) (PEO) and an anionic sodium dodecyl sulfate (SDS) at different SDS concentrations. Using NMR diffusometry, we measured the self-diffusion coefficients of the polymer (PEO) and surfactant (SDS) components simultaneously as a function of SDS  concentration. Also, we obtained NMR relaxation rates for PEO and the chemical shifts as a function of SDS concentration. Using a simple model to interpret our experimental results, we developed a precise  method to identify the onset of aggregation of SDS on PEO chains (critical aggregation concentration CAC=3.5 mM) and a crossover concentration (C2 = 60 mM) which is associated with a sharp change in the relaxation behavior, as well as an increase in free surfactant concentration. Moreover, in the context of a simple model, we identified the SDS concentration (Cm = 145 mM) beyond which the diffusion of the aggregates was strongly hindered by the presence of other structures such as free micelles. -- Another source of hindered diffusion, apart from macromolecular crowding, is diffusion in the presence of geometrical constraints. In the case of cylindrical or wormlike micelles, the constraint is to diffuse within the cylinder. Aggregates in a multi-component wormlike micelle are difficult to study via scattering techniques because they would require contrast matching. Therefore, We studied a system composed of a zwitterionic surfactant N-tetradecyl-N, N-dimethyl-3-ammonio-1-propanesulfonate (TOPS) and an anionic surfactant SDS in brine. NMR diffusometry indicates that the self-diffusion coefficients of surfactant is consistent with restricted diffusion within a reptating micelle. Using a simple model to interpret our diffusometry results, we estimated the average end-to-end micellar distance to be ͌ 1 μm. Using NMR relaxometry, we obtained the wormlike micelle overlap concentration (a characteristic concentration Cthreshold = 4.5 mM). Deuterium NMR spectra indicate that the internal structure of the wormlike micellar system includes domains with different orientation orders with slow exchange between domains. Our experimental results (NMR diffusometry and rheometry) revealed that the wormlike micelles exhibit remarkable polymer-like scalings with a crossover from Zimm-like (diffusion) to Rouse-like (rheology) regimes. -- During the latter part of my PhD, we explored protein solutions . We were motivated by the fact that scattering techniques in concentrated lysozyme protein solutions show conflicting reports over the existence of an equilibrium cluster phase. It is recognized that protein aggregation is essential in understanding the biophysics of proteins. Also, it must be noted that protein aggregations and misfoldings, which are implicated as a root cause of some diseases that are thus sometimes called “conformational diseases” are technically challenging to quantify. To address this problem,  we worked on diffusion of lysozyme proteins in concentrated lysozyme solutions. Lysozyme is a common mammalian protein, which is found in human amylases. Using NMR diffusometry, we obtained the self-diffusion coefficients of lysozyme in concentrated lysozyme solutions. Diffusometry and relaxometry showed that both the observed diffusion coefficient and relaxation rates are a weighted average of monomer and aggregate fraction s. Therefore, our studies gave a strong evidence for both lysozyme monomers and thermodynamically stable lysozyme clusters in the protein solution with a rapid exchange between monomer and aggregate on the NMR time scale. -- Finally, we addressed a practical problem of relevance to biochemists and biophysicists. Studying the dynamics of macromolecules and aggregates in multicomponent systems composed of peptide or protein and surfactants is challenging. Many peptides and proteins are synthesized in tiny quantities. We used NMR diffusometry and relaxometry to explore systems composed of peptides that are very long compared to the surfactant, dissolved with an anionic surfactant in an aqueous solution. We compared the results to those for shorter dipeptides whose size is comparable to the surfactant. Diffusometry shows that the longer peptide behaves as if there is no free fraction of peptide molecules in the solution. Based on that, we extracted reliable physical quantities such as the true hydrodynamic radius of long peptide-surfactant aggregate as a function of surfactant concentration. On the other hand, the smaller dipeptides are partitioned between the bound and free state such that the fraction of the bound peptide varies with surfactant concentration.


identifier: Batstone, Rebecca <https://research.library.mun.ca/view/creator_az/Batstone=3ARebecca=3A=3A.html>   (2012) The evolution of thyasirid clams (bivalvia: thyasiridae) from a subarctic fjord in Bonne Bay, Newfoundland.  Masters thesis, Memorial University of Newfoundland.

type: Thesis NonPeerReviewed

format: application/pdf application/pdf

abstract: In process


identifier: Kader Bathia, Wasiim Mohammad <https://research.library.mun.ca/view/creator_az/Kader_Bathia=3AWasiim_Mohammad=3A=3A.html>   (2012) Ornamental fish as complementary species in aquaponics.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Bohloul, Saeed <https://research.library.mun.ca/view/creator_az/Bohloul=3ASaeed=3A=3A.html>   (2012) Theoretical study of tunneling conductance in normal-metal/insulator/PrOs₄Sb₁₂ junctions.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Bojman, Kerri M.(Kerri Michelle) <https://research.library.mun.ca/view/creator_az/Bojman=3AKerri_M=2E=28Kerri_Michelle=29=3A=3A.html>   (2012) An examination of the relationship between emotion regulation and alexithymia.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Brothen, David Lorentz <https://research.library.mun.ca/view/creator_az/Brothen=3ADavid_Lorentz=3A=3A.html>   (2012) Using the AVOW diagram analogy for teaching DC circuits from a conceptual change perspective.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Brown, Mark A.(Mark Andrew) <https://research.library.mun.ca/view/creator_az/Brown=3AMark_A=2E=28Mark_Andrew=29=3A=3A.html>   (2012) A comparison of absolute identification and function learning.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Buchanan, Kiah R.(Kiah Rikki) <https://research.library.mun.ca/view/creator_az/Buchanan=3AKiah_R=2E=28Kiah_Rikki=29=3A=3A.html>   (2012) Teachers' experiences and perceptions in working with students who have attempted suicide.  Masters thesis, Memorial University of Newfoundland.

abstract: A suicide attempt is a key risk factor for completed suicide. Teachers are often on the front line with students who have attempted suicide. No one has, however, asked about the impact of having a student in the classroom who has attempted suicide. This study utilized semi-structured interviews with six intermediate/secondary teachers in Newfoundland and Labrador concerning their experiences (the event) and perspectives (thoughts and feelings related to the event) of working with a student who has returned to the classroom after an attempted suicide. Interview data was transcribed verbatim by the first researcher and returned to participants for review. Coding was utilized to determine common themes among the data (Farber 2006). Findings indicate teachers experienced shock, uncertainty, anxiety, and fear in how to deal with such situations and in terms of the potential implications of such situations. As well, participants reported issues around access to student information and knowledge regarding appropriate actions. They recommended proactive and inclusive policy/program development as well as training in the area of preventing student suicide attempts. Study results are discussed in the context of the needs of students who have attempted suicide, the needs of teacher, and the role of the wider school system.


identifier: Bush, Warren Oliver <https://research.library.mun.ca/view/creator_az/Bush=3AWarren_Oliver=3A=3A.html>   (2012) Industrial disasters at sea around Newfoundland & historicizing maritime peril : 1914-1918.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Chini, Reza <https://research.library.mun.ca/view/creator_az/Chini=3AReza=3A=3A.html>   (2012) Marine energy harvesting from low cut-in speeds horizontal axis ocean current turbine: design, optimization and analysis of the rotor.  Masters thesis, Memorial University of Newfoundland.

abstract: Energy extraction from tidal currents using marine current turbines has been gaining attention in recent years. In the first part of this thesis, the design and optimization of a horizontal axis turbine is proposed to harvest available ocean kinetic energy from very low speed flow regimes. A horizontal axis marine current turbine is modeled and NACA 4 series foils are selected as the two-dimensional blade foils design domain. Blade geometry and foil shape are then optimized using Response Surface (RSM) and Steepest Ascent Methodologies (SAM). The performance and accuracy of the proposed design is compared and validated with the developed turbine Blade Element Momentum (BEM) theory model. In the second part of the thesis, hydrodynamic properties of the optimized foil are simulated through a commercial Computational Fluid Dynamic (CFD) package and then compared with the conventional Eppler 61 foil properties. The two-dimensional analysis confirms the effectiveness of the optimization for the Reynolds number of 42000. A three dimensional start-up CFD simulation is then performed to calculate the unsteady load distribution over the blade surfaces which have been further utilized in a static Finite Element Analysis (FEA) to measure the rotor's blade tip deflection. This stage guarantees the safe and optimum structural performance of the rotor in regard to various existing material choices and manufacturing technologies.


identifier: Connolly, Creighton P.(Creighton Paul) <https://research.library.mun.ca/view/creator_az/Connolly=3ACreighton_P=2E=28Creighton_Paul=29=3A=3A.html>   (2012) Singapore is a gold mine: re-orienting international flows of secondhand electronics.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis examines the processing and trading practices within the in/formal economy surrounding secondhand electronics in Singapore and its surrounding region by asking two main questions: first, it asks how the international trade networks for electronic waste are formed, organized and regulated by considering who and what are the actors enabling the trade; second, it considers to what extent il/legality or il/licitness is or is not a characteristic of these trading practices. This thesis builds on previous work demonstrating that there are no clear boundaries between the il/legal or the in/formal and evaluates the (in)effectiveness of legislative measures employed at varying levels of jurisdiction to regulate the trade in secondhand electronics. The Basel Convention is the international treaty that supposedly regulates the international trade and traffic in hazardous (including electronic) waste, yet there are several shortcomings in the Convention which leave room for exploitation. A key finding of this thesis is Singapore's role as a global source of secondhand electronics to developing regions, which contradicts the logic of mainstream publications criticizing e-waste flows to the developing world, and is a pattern not accounted for in the laws of the Basel Convention. -- Key words: E-waste; Singapore; Basel Convention; legal geographies; informal economies; licit/illicit trade.


identifier: Conway, Megan G.(Megan Gabriella) <https://research.library.mun.ca/view/creator_az/Conway=3AMegan_G=2E=28Megan_Gabriella=29=3A=3A.html>   (2012) HspB1 protection against amyloid-ß toxicity.  Masters thesis, Memorial University of Newfoundland.

abstract: Alzheimer's disease (AD) is hallmarked by the presence of neurofibrillary tangles and amyloid-β plaques. Amyloid-β plaques consist of the amyloid-β peptide (Aβ) that has been shown to induce toxic effects on neurons through the activation of stress-related signalling and neuronal loss. The small heat shock protein, HspB1 (also referred to as Hsp27 and Hsp25 in mouse), is accumulated in 15% of neocortical amyloid-β plaques in AD brains (Wilhelmus, 2006). Whether this represents a potentially protective response to stress, or is part of the disease process is unknown. We have previously reported that expression of HspB1 not only protects cortical neurons against amyloid toxicity, but also enhances total neurite growth in these neurons(King et al., 2009). -- The amyloid-β peptide is derived from the proteolytic processing of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Mutations in  APP alter secretase cleavage sites, resulting in higher production of the toxic Aβ(1-42) peptide that undergoes aggregation more readily. Since HspB1 has been shown to protect neurons against amyloid toxicity, it is conceivable that HspB1 may interact directly with Aβ or APP. Recent studies have demonstrated exogenous HspB1 binding to synthetic Aβ. We have replicated these results in an attempt  to determine the role of HspB1 in the inclusion of Aβ aggregates. We hypothesize that HspB1 interacts with Aβ or its precursor APP, to either alter the distribution of Aβ/APP within the cell, or its release from the cell. -- In order to test our hypothesis, we incubated His-tagged HspB1 with synthetic Aβ(1-42), at physiological temperature 37°C overnight. Immunoprecipitation, using agarose protein A/G beads incubated with the monoclonal anti-His primary antibody, was used for our primary analysis of interaction. Western blotting of the nitrocellulose membrane, using the 6E10β-amyloid (1-16) mouse monoclonal antibody, demonstrates  that Aβ is immunoprecipitated with His-HspB1. These results point to a direct interaction between HspB1 and Aβ(1-42). We investigated the interaction of HspB1 with APP in HEK293 cell line expressing wild-type APP (APP-wt) or APP-swedish mutation (APP-swe) that predominately yields Aβ(1-42) through immunoprecipitation. His-tagged HspB1 was incubated with the conditioned media from the APP-wt and APP-swe cells  overnight at 37°C. Immunoprecipitation was performed using magnetic protein A/G beads incubated with either 6E10β-amyloid (1-16) mouse monoclonal antibody, or anti-HspB1 human (SPA-803)rabbit polyclonal antibody. Subsequent western blotting of the nitrocellulose membrane using the 6E10 and the 803 antibodies demonstrate that APP is immunoprecipitated with His-HspB1. -- These data suggest HspB1, perhaps via its chaperone activity, may be altering production of APP and/or Aβ within the cell preventing secretion into the extracellular environments.


identifier: Cooper, Kathryn Frances <https://research.library.mun.ca/view/creator_az/Cooper=3AKathryn_Frances=3A=3A.html>   (2012) Dog-assisted reading programs: a quest for alternative approaches to reading and learning for children.  Masters thesis, Memorial University of Newfoundland.

abstract: Reading challenges face many students daily in ourschools in  this province. Difficulty with reading impacts every subject  area. A balanced literacy program must have variety and teachers need several tools at their disposal to support their students. Dog-assisted reading programs are unique reading interventions that have shown tremendous promise across Canada and Internationally. Dog-assisted reading has potential for some of our students and teachers in Newfoundland and Labrador where there is, as yet, no such program. Along with improved reading, intimate time with a dog promotes empathy and, kindness, and it can deepen connections to the environment. In this thesis, I argue for the need for dog-assisted reading in Newfoundland and Labrador. Supported by the literature on literacy, learning,  motivation, and emotion, as well as literature about dog therapy and dog assisted reading therapy, the necessity for a program of dogs and reading is hard to ignore. Following a  review of several existing programs, a pilot program is proposed. This program connects to curriculum outcomes and expectations beyond the curriculum that can be met through dogs and reading.


identifier: Darmonkow, Valerie Zdravka <https://research.library.mun.ca/view/creator_az/Darmonkow=3AValerie_Zdravka=3A=3A.html>   (2012) Barriers to access to and uptake of genetic services from the perspectives of genetic professionals.  Masters thesis, Memorial University of Newfoundland.

abstract: This research examines barriers to the provision of genetic services from the perspectives of genetics professionals working in the province of Newfoundland and Labrador, Canada. Based on open-ended and semi-structured key informant interviews, the study assesses the structure and capacity of the Provincial Genetic Services Program, the referral process and protocols followed, and the social, historical, and cultural factors shaping the utilization of genetic services from the perspectives of those who provide the services. The thesis reports on the factors that support  the use of genetic services and factors that deter or decrease this use. It identifies strategies for overcoming challenges to access to and uptake of genetic services. The key findings are incorporated into recommendations to help define areas and directions for improvements in clinical genetics and to provide advice for those who develop and deliver genetic services.


identifier: Desjardins, Mariève <https://research.library.mun.ca/view/creator_az/Desjardins=3AMari=E8ve=3A=3A.html>   (2012) Molecular and seasonal basis for freeze resistance in wolffish species (Anarhichas lupus, A. minor and their hybrids).  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: During winter, the coastal waters of Newfoundland can be considered a "freeze risk ecozone" for teleost fishes. The benthic Atlantic (Anarhichas lupus - AW) and spotted wolffish (A. minor - SW) reside at opposite ends of this ecozone, with the AW facing the greatest risk because of its  shallower niche. To resist freezing, AW secretes five times the level of plasma antifreeze protein (AFP) activity than does SW. -- The main basis for this difference in plasma AFP  levels is gene dosage, as AW has approximately three times more AFP genes than SW. Perhaps as a result, AFP transcript levels in liver (the primary source of circulating AFP's) are several times higher in AW. One explanation for these gene and transcript dosage differences is the presence of tandemly arrayed AFP gene repeats in AW that make up two-thirds of its AFP gene pool. Such repeats are not present in  SW. AW and SW diverged from a common ancestor at a time when  the ebb and flow of northern glaciations would have resulted  in the emergence of "freeze risk ecozones". The duplication/amplification of AFP genes in a subpopulation of  ancestral wolffish would have facilitated the exploitation of this high risk habitat, resulting in the divergence and evolution of modem day AW and SW species. -- Investigations on artificially produced AW/SW hybrids showed that all the AFP genes of SW are likely shared with AW, which supports recent gene amplification as an impetus for speciation. The high dynamism of the AW AFP locus (through high variability in dosage and organisation) was best visualized in the single haplotype inherited by the hybrids. Their intermediate levels of plasma AFPs make these fish unfit for survival within the shallowest part of the "freeze risk ecozone". -- While the total levels of AFP gene transcripts varied little from winter to summer in both species (especially in the liver), differential expression of members of the two subfamilies of type III AFPs, the SP- and QAE-type genes (appellation based on the ion-exchange Sephadex resins to which each type of isoform binds), was observed. While the expression of the QAE-type transcripts was ubiquitous (both temporally and spatially), that of the SP-type genes seemed to show some level of tissue specificity, which highlights the complex evolutionary history of these genes.


identifier: Ditlecadet, Delphine <https://research.library.mun.ca/view/creator_az/Ditlecadet=3ADelphine=3A=3A.html>   (2012) Glycerol metabolism in smelt (Osmerus mordax).  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Rainbow smelt (Osmerus mordax) is a small fish that accumulates high amounts of glycerol in winter as a cryoprotectant. The principal objective of my thesis was to investigate the metabolic control of the synthesis and clearance (loss/catabolism) of glycerol in this species. As rainbow smelt lose 4-13% of their glycerol content daily, they have to vigorously synthesize this metabolite at temperatures below 0ﾟC to reach the exceptional levels reported (> 200 mM). In this context, the two main hypotheses of my thesis were: 1) glycerol loss/catabolism might be turned-off during the accumulation period and be turned on during the decrease period; and 2) the last step of glycerol synthesis, leading from glycerol-3-phosphate (G3P) to glycerol might be direct, involving a single reaction catalyzed by glycerol 3-phosphatase (G3Pase), an enzyme not yet convincingly described in any animal species. -- Activity and mRNA levels of glycerol kinase (GK), the first enzyme involved in glycerol breakdown, were measured in liver, the tissue displaying the highest activity in vertebrates. mRNA levels did not change over the cycle but GK activity did, suggesting a regulation at a post transcriptional level. Overall, GK activity was so low in liver, and in all other tissues assayed, that it likely has a minor quantitative role in glycerol clearance. Daily loss toward water was also determined over the cycle but was not lower over the accumulation period, ruling out the presence of any mechanisms to retain glycerol during this period. Taken together, these results suggest that glycerol levels are dictated primarily by the rate of glycerol synthesis. -- To produce glycerol, G3P can be directly dephosphorylated by  a G3Pase, as in yeast (Saccharomyces cerevisiae) or can enter the triacylglycerol pool and then be released as glycerol via reactions well recognized in mammals. Lipid content and activities of G3Pase and key enzymes involved in  lipid metabolism were measured over the glycerol cycle in liver, the site of glycerol synthesis. Lipid content did not  change over the cycle and was too low to account for a significant amount of glycerol, but activities of G3Pase and  of enzymes involved in lipid degradation were up-regulated early in the cycle, at the onset of glycerol accumulation. A  second set of experiments was performed using isolated smelt  hepatic cells incubated in optimal conditions to produce glycerol over 72h in the presence or absence of a potent inhibitor of lipid synthesis. It was shown that neither on-board lipids nor newly synthesized lipids could be the source of the glycerol produced, pointing out for the first time a direct dephosphorylation by G3Pase as the main source  of glycerol in an animal species. -- The last objective of my thesis was to partially purify and characterize G3Pase from smelt liver. The enzyme is most likely a cytosolic, acidic, low molecular weight phosphatase, in contrast to other species where the enzyme was previously purified and that has an optimal activity at neutral pH. -- These results  are crucial in terms of understanding glycerol metabolism in rainbow smelt but also for the elucidation of pathways involved in glycerol synthesis in vertebrates as they clearly showed that glycerol is not necessarily only a by-product of lipid degradation.


identifier: Drew, Matthew Charles <https://research.library.mun.ca/view/creator_az/Drew=3AMatthew_Charles=3A=3A.html>   (2012) 3D inversion modelling of the Nechako Basin, British Columbia, magnetotelluric data set.  Masters thesis, Memorial University of Newfoundland.

abstract: The Nechako Basin is an intermontane basin situated in south central British Columbia, Canada. Due to a desire for an alternative source of employment stemming from the impact of the mountain pine beetle on the forestry industry, the government of British Columbia has commissioned several geophysical and geological surveys of the area in order to assess its hydrocarbon potential.  This sedimentary basin is covered with a layer of volcanic extrusive rocks which renders seismic methods nearly ineffective. As an alternative, a magnetotelluric (MT) survey was performed in order to determine subsurface conductivity and structure. Data from this survey were used in this thesis to produce a 3D conductivity model of the subsurface, by running multiple inversions with varied parameters. Data from four profiles as well as additional sites filling in gaps between profiles were used: Profile A ran west of Nazko. Profile B ran south of Nazko, Profile C ran north-west of Nazko, and Profile D ran east from Nazko toward Quesnel. Models from inversion of this MT survey show sensitivity to thicker surface volcanic rock and show where these bodies may thin or pinch out (e.g. conductivity at the west end of profile A and south end of Profile B). Additionally potential faulting and partial melt is seen in the subsurface, in profile D and at depth between profiles A and C respectively. 3D inversion models have provided information in addition to previous 2D results, giving a different placement of features out of the restricted plane of 2D inversion and showing lateral extent of conductivity anomalies, thus contributing to hydrocarbon exploration in the Nechako Basin.


identifier: Dunne, Bradley Steven <https://research.library.mun.ca/view/creator_az/Dunne=3ABradley_Steven=3A=3A.html>   (2012) Ancient quarrel or sibling rivalry?: reconciling philosophy and poetry in Plato.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis will attempt to challenge the cogency of Plato's  anti-poetry position by dissolving the supposed opposition between philosophy and poetry. By surveying the claims Socrates makes that dismiss poetry and privilege philosophy, we discover that Socrates' antagonism stems from a charge that poetry does not require any discernible skill and is related to an irrational part of the human psyche; conversely, philosophy is superior because it requires a skill (dialectic) and is a strictly rational activity. However, this thesis argues that this is an unfair characterization of both philosophy and poetry. Firstly, we explore how the dialogues themselves undermine Socrates' championing of rationality and logos. This will take up the majority of the thesis. Secondly, we revaluate poetry by turning to Viktor Shklovsky's characterization of poetry, which illuminates the skill of poetry. Finally, we end by illustrating how philosophy and poetry are congruous insofar  as they both force the individual to consider new ways of thinking.


identifier: Elliott, Bradley James <https://research.library.mun.ca/view/creator_az/Elliott=3ABradley_James=3A=3A.html>   (2012) Centrifuge modeling of steel catenary risers in the touchdown zone.  Masters thesis, Memorial University of Newfoundland.

abstract: Field surveys of installed catenary risers have shown the creation of deep trenches cut into the seabed around the touchdown point. This section is a critical to the fatigue life of Steel Catenary Risers (SCRs) as it consists of a repetitive complex fluid-riser-soil interaction and often contains the maximum deflection and bending moment. Current practice and design programs typically assume a flat, rigid, "non-interacting" seabed and do not account for the complex nonlinear processes associated with the repetitive interaction of the riser with the seabed and trench formation. An important step forward in the state-of-the-art would therefore be to improve the fluid-riser-soil interaction models that are currently used in the analysis and design procedures for steel catenary risers. -- The thesis presented herein focuses on the development of a novel centrifuge experimental tool for modeling a 0.5 m outside diameter, 108 m long steel catenary riser at the touchdown zone and to investigate the trench formation mechanism arising from the fluid-riser-soil interaction and its influence on the fatigue stresses.  This thesis provides the details of a SCR model developed for the geotechnical centrifuge at C-CORE, the associated scaling laws, and the results of two series of physical tests along with the confirmatory finite element analyses.  Further, it discusses the current status of the state-of-the-art on steel catenary riser modeling at the touchdown zone, identifies the knowledge gaps, and provides recommendations for future research based on physical and numerical models. -- The results of the physical tests indicated that the SCR model was consistent with engineering theory and centrifuge scaling laws, verified using finite element analysis. It was also demonstrated that there was a considerable reduction in  bending and tensile fatigue stresses due to the change of trench geometry and the increase in trench depth from its original mudline state, potentially increasing the fatigue life of the SCR.


identifier: Eslamibidgoli, Mohammad Javad <https://research.library.mun.ca/view/creator_az/Eslamibidgoli=3AMohammad_Javad=3A=3A.html>   (2012) Density functional theory study of solid-state structure and optoelectronic properties of fluorene-based conjugated polymers.  Masters thesis, Memorial University of Newfoundland.

abstract: Using the dispersion corrected density functional theory (DFT-D/B97D) approach, we have performed molecular and solid-state calculations to study the influence of intra- and inter-molecular interactions on the bulk structure and the electronic and optical properties of fluorene-based conjugated polymers. In particular, we investigate the role of side-chain length on the molecular parking and optical properties of poly (9.9-di-n-alkylfluorene-alt-benzothiadiazole) or FnBT's where n is the number of CH₂ units in the alkyl side-chains. The results indicate that for the FnBT with longer side-chains, due to the significant inter-molecular interactions between the side-chains, the packing of these polymers forms a lamellar structure. On the other hand, for the FnBT with shorter side-chains, the cylindrical phase is more favorable and the corresponding crystals are almost hexagonal. These different packing structures can be attributed to the microphase separations between the flexible side-chains and the rigid backbones and are in agreement with previous investigations for other hairy-rod polymers [1, 2]. In addition, as a result of the efficient inter-chain interactions for the lamellar structures, the dihedral angle between the F and BT units is reduced by about 30ﾟ providing a more planar backbone which in turn leads to a decrease of about 0.2eV and 0.3 eV, in the band gap of the lamellar structure relative to its value for the gas and cylindrical phases respectively. Time-dependent DFT is also used to study the excited states of the monomer of FnBT with various lengths of side chains.


identifier: Fifield, Kathleen Elizabeth <https://research.library.mun.ca/view/creator_az/Fifield=3AKathleen_Elizabeth=3A=3A.html>   (2012) Inhibition of mTOR kinase via rapamycin blocks persistent predator stress-induced hyperarousal.  Masters thesis, Memorial University of Newfoundland.

abstract: Traumatic, stressful life events are thought to trigger acquired anxiety disorders such as post-traumatic stress disorder (PTSD). PTSD is characterised by several symptoms including both associative and non-associative tear memories. It has been previously established that the mammalian target of rapamycin (mTOR) pathway plays a key role in associative fear memories: however, it is unknown whether this pathway attenuates non-associative fear memories (or fear sensitization). Thus, the goal of these experiments was to examine the role of mTOR in non-associative fear memories. In the current set of experiments, non-associative fear memories were produced by predator stress. Predator stress involves an acute, unprotected exposure of a rat to a cat which causes long-lasting non-associative fear memories expressed as generalized hyperarousal (manifested as increased startle response and anxiety-like behavior and measured in the elevated plus maze, hole board and light/dark box). Here, we show that rapamycin. When given before (Experiment I) or after (Experiment 2) stress, attenuated predator stress induced hyperarousal, lasting at least three weeks. In addition, rapamycin blocked a subset of anxiety-like behaviors. Furthermore, when re-exposed to the predator stress context, rapamycin-treated predator stressed rats showed increased activity compared to vehicle controls. These data suggest that rapamycin blocks consolidation of predator stress-induced non-associative and associative fear memories. In a second set of experiments, we examined the effects of rapamycin following reactivation (Experiment 3) and without reactivation (Experiment 4) of predator stress-induced fear memories on non-associative  fear memories. A single, 10 minute re-exposure to the predator stress context was sufficient to extinguish predator stress -induced hyperarousal (Experiments 3, 4). Rapamycin blocked this extinction (Experiment 3). We also show that, consistent with previous data, rapamycin significantly reduced weight gain lasting at least four weeks (Experiments 1-4). Taken together with past research, our results indicate that mTOR regulation of protein translation is required for consolidation of both associative and non-associative fear memories. Overall, these data suggest that rapamycin, a drug already in clinical trials, may be a novel treatment for patients suffering from acquired anxiety disorders such as PTSD.


identifier: Fisher, Christopher M.(Christopher Michael) <https://research.library.mun.ca/view/creator_az/Fisher=3AChristopher_M=2E=28Christopher_Michael=29=3A=3A.html>   (2011) Improvements in in situ isotopic microanalysis: U-Pb and Lu-Hf analysis of zircon, Sm-Nd analysis of rare earth rich accessory minerals.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Fitzpatrick, Cheryll <https://research.library.mun.ca/view/creator_az/Fitzpatrick=3ACheryll=3A=3A.html>   (2012) The role of situation model dimensions in math word problems.  Masters thesis, Memorial University of Newfoundland.

abstract: Math word problems can be quite challenging to students. In recent years, the math word problem literature has emphasized the importance of situation models (SM). SMs are a way of building a mental representation (using the text and previous knowledge) organized around five dimensions: protagonist, causal, motivational, temporal, and spatial. Wording of math word problems was manipulated to reflect two of these dimensions - spatial and motivational. Spatial (associated and dissociated) and motivational (motivational and neutral) questions were  given to grades 3 and 5 students. Gender and grade were found to interact with performance in the spatial dimension, while only gender interacted with performance in the motivational dimension.


identifier: Garland, Shaun W.(Shaun Walter) <https://research.library.mun.ca/view/creator_az/Garland=3AShaun_W=2E=28Shaun_Walter=29=3A=3A.html>   (2012) Production and performance of the native Newfoundland plant species Alnus viridis subsp. crispa, Betula papyrifera, Cornus stolonifera and Myrica gale for restoration (Granite Canal, South-Central Newfoundland, Canada).  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Ghanim, Daw Farag Daw <https://research.library.mun.ca/view/creator_az/Ghanim=3ADaw_Farag_Daw=3A=3A.html>   (2012) Experimental determination of equivalent circuit parameters for a laborator salient-pole synchronous generator.  Masters thesis, Memorial University of Newfoundland.

abstract: Nearly all of the electric energy used for numerous applications in today's world, regardless of the assembly of the used prime movers, is generated by means of synchronous generators. These generators can be connected together in small-scale or large-scale generation power systems depending on the load demand. Indeed, it is of utmost necessity to pay serious attention to those electric machines, their performance characteristics, various operation conditions and their design parameters. One of the most important parameters of the synchronous generator that can be a good asset for synchronous machines designers is the synchronous reactance. The importance of this reactance lies in the significant role it plays in the quality of the produced electric power and thus the stability of the voltage obtained across the terminals of a synchronous generator. The synchronous reactance of a synchronous generator may have different values based on the mode of the operation or the loading conditions. The primary purpose of this thesis is to determine the direct-axis synchronous reactance values as well as the identification of stator leakage reactance of a real synchronous generator from the so-called Potier triangle method. A set of standard tests based on the IEEE standard 115 is set forth and conducted on the machine under test which is a laboratory synchronous generator of a salient-pole type, or so-called hydroelectric or waterwheel generator. The experimental test data and results are provided and analyzed with full details, and then the relevant machine parameters are calculated at the end of this thesis.


identifier: Gladney, Krista H.(Krista Hanorah) <https://research.library.mun.ca/view/creator_az/Gladney=3AKrista_H=2E=28Krista_Hanorah=29=3A=3A.html>   (2012) Heteroclitic peptides enhance IL-2 production and recognition breadth of HIV-specific CD8+ T Cells.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Guiry, Eric James <https://research.library.mun.ca/view/creator_az/Guiry=3AEric_James=3A=3A.html>   (2012) Dogs as analogs in stable isotope-based human paleodietary reconstructions: assessing the Canine Surrogacy Approach.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Hazenberg, Evan Nicholas Leo <https://research.library.mun.ca/view/creator_az/Hazenberg=3AEvan_Nicholas_Leo=3A=3A.html>   (2012) Language and identity practice : a sociolinguistic study of gender in Ottawa, Ontario.  Masters thesis, Memorial University of Newfoundland.

abstract: [S]ocial identity is not usually explicitly encoded by language but rather is a social meaning that one usually infers on the basis of one's sense of [...] linguistic constructions. -- (Ochs, 1993: 289) -- Contemporary theories posit that gender is performative (e.g., Butler, 1990): that it is something one does rather than something one has. Early variationist sociolinguists (e.g., Labov, 1963) saw sex as a social variable, while later researchers (e.g., Livia & Hall, 1997) focused instead on gender, including expressions of sexuality. The study of transsexuality and language variation is a recent addition to the field (e.g., Kulick. 1999). -- This study examines three sociolinguistic variables ([s], intensifiers, and prosodic variation) across a six-cell gender division (straight men and women, queer men and women, and transsexual men and women) in Ottawa, Canada, to investigate the linguistic resources that are used in the construction and presentation of gender. These variables show different patterns of usage across the gender groups, suggesting a relationship between the markedness of a variable (how aware speakers are that it indexes gender) and the strategies speakers adopt in using it. Transsexual speakers avoid using extremely gender-marked forms, while straight men use linguistic cues to distance themselves socially from queer men. These patterns are supported by Bucholtz & Hall's (2005) framework of sociocultural linguistics, which argues for an interactional model of identity and performance.


identifier: Hillier, Ashley Michelle <https://research.library.mun.ca/view/creator_az/Hillier=3AAshley_Michelle=3A=3A.html>   (2012) Interaction of serum lipids with lung surfactant as models of acute respiratory distress syndrome (ARDS).  Masters thesis, Memorial University of Newfoundland.

abstract: Lung surfactant (LS) is a lipid-protein mixture secreted by type 11 alveolar cells to the air-water interface of the alveoli. LS stabilizes the alveoli and prevents lung collapse during respiration. This occurs by surfactant forming a surface active film at the interface to lower the surface tension (γ) to very low values (~1 mN/m) at end expiration. Under certain conditions, LS can become dysfunctional. This is seen during acute respiratory distress syndrome (ARDS) and lung injury, among other lung diseases. During ARDS, serum components, possibly soluble serum proteins and lipids, or a combination of both, can leak into the alveolar space and thereby inactivate LS. Previously it was found in our laboratory that serum, as a whole entity, was two hundred times more potent an inhibitor than its individual protein components. This could suggest that there are possibly other components of serum than soluble proteins which are potent inactivators of LS. -- Interactions of a bovine lipid extract surfactant (BLES) with varying amounts of whole fetal calf serum (FCS), cholesterol, and low density lipoprotein (LDL) were studied using several biophysical techniques to examine serum lipid components and their effects on the structure and function of BLES in films and bilayers. BLES contains all lipids and hydrophobic proteins of LS except neutral lipids (like cholesterol) and the hydrophilic surfactant proteins A and D. This allowed us to study the effects of normal and excess cholesterol, lipoproteins and other serum lipidic materials on this surfactant system. Mass spectrometry and lipid Iatroscan showed LDL and serum lipid fraction to contain significant amounts of cholesterol-ester and lipids not found in BLES. From our adsorption studies both serum and low density lipoprotein (LDL) hindered the ability of BLES bilayer dispersions to rapidly form films at the air-water interface. However, low physiological amounts (5-10%) of cholesterol did not disturb the rate of adsorption of BLES. Langmuir-Blodgett films were studied using a Langmuir-Wilhelmy balance to study surface activity and structure of such adsorbed films. All serum lipid components except physiological concentrations of cholesterol (5-10% wt) significantly decreased the surface activity of the films. -- Images of these films obtained by atomic force microscopy (AFM), suggested that normal amounts of cholesterol formed gel-like condensed domains until compressed to a low γ. This domain formation was abolished at higher cholesterol concentrations. Whole serum, high cholesterol and LDL prevented BLES domain formation as well as γ reduction and in fact produced non-gel domains. Bilayer dispersions of such samples (used to form the adsorbed films), using Raman spectroscopy, suggested that serum components altered the bond vibrational modes of the fatty acyl chains (C-H, C-C) of BLES phospholipids, compared 10 serum proteins alone. The bilayer studies suggested that serum lipids components affected the fluidity and lipid packing of BLES and thereby possibly altered molecular arrangements and packing of films formed from such bilayer. The study suggests a molecular model of serum lipid component as an inactivator of LS in ARDS. -- The monolayer and bilayer studies suggested that these lipid components are far more potent inhibitors of LS than their protein counterparts and are able to disturb lipid packing and change structure and surface activity of LS.


identifier: Hollett, Michelle Lela <https://research.library.mun.ca/view/creator_az/Hollett=3AMichelle_Lela=3A=3A.html>   (2012) Finding family through the trees : emotional meaning in felling, milling and building.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Al Hujran, Tayel <https://research.library.mun.ca/view/creator_az/Al_Hujran=3ATayel=3A=3A.html>   (2012) Synthesis and characterization of macrocyclic naphthalene ring-based calix[n]arenes, lactones and amides.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The work described in this thesis is concerned mainly with the synthesis of some new molecular receptors which are naphthalene ring-based calixarenes, lactones and amide macrocycles. Their complexation properties with fullerenes C₆₀ and/or cationic guests such as tetramethylammonium acetate and/or alkali metal cations were studied. -- In Chapter 2, the syntheses of the macrocycle lactones and their clathrates are described. The structures of these macrocycles were determined by X-ray analysis which revealed that they formed either cage or channel-type clathrates when crystallized from different solvents. -- The work described in the Chapter 3 concerns the synthesis of a series of new di- and tetraamide macrocycles, respectively, from the [1+1] and [2+2] fragment cyclocondensation reactions of 4,4'-methylenebis(3-methoxy-2-naphthoyl chloride) and its derivatives with 1,8-diamino-3,6-dioxaoctane or with 1,10-diamino-4,7-dioxadecane. -- In Chapter 4, synthetic studies are described toward unprecedented acenaphthene, ring-based calixarene analogues, which could serve as wider and deeper bowl-shaped cavity-containing molecular receptors. The syntheses of homooxacalix[4]acenaphthene was achieved using a [2+2] fragment condensation strategy. Its X-ray structure showed the macrocycle in an 1,3-alternate conformation. As determined by ¹H-NMR spectroscopy, homooxacalix[4]acenaphthene was found to be a moderately good host for complexation with C₆₀  in toluene-d₈ solution. -- In Chapter 5 a series of new mixed naphthalene ring-based homooxacalix[4]arenes were synthesized also by employing a [2+2]-type fragment condensation reaction. X-ray structures of octahomotetraoxacalix[2]naphthalene[2]pyridine crystals grown from two different solvent systems revealed that the structures adopted 1,3-alternate and cone conformations. ¹H-NMR titration studies for this macrocycle revealed it to be a good host for binding TMAA in CDC1₃  solution in 1:1 ratio.


identifier: Emtehani Jahromi, Kambiz <https://research.library.mun.ca/view/creator_az/Emtehani_Jahromi=3AKambiz=3A=3A.html>   (2012) Drill string axial vibration and sonic head analysis.  Masters thesis, Memorial University of Newfoundland.

abstract: This study contains several analyses about vibration generation devices and axial vibration in the drill string. Advanced Drilling Group (ADG) has been seeking new technologies in drilling to improve the rate of penetration (ROP), and in this regard several vibration generation devices for rotary drilling have been reviewed for further analysis. The Sonic Head Drill (SHD) is one of the most prominent drilling tools in shallow depth drilling, and is the focus of the first part of this study. This study attempts to determine if this tool can be used for laboratory and field tests, and if the concept of unbalanced masses used in the SHD can be successful in oil and gas drilling. In order to determine the feasibility and ease of use of the SHD, a series of tests and simulations were conducted in this thesis. A sonic head is surrounded by four isolators. These isolators are experimentally characterized and the force transmitted to the rock and the frame is predicted. Several other vibratory systems were also reviewed and a basic model of a vibratory system based on the SHD principle is proposed. The vibration generation device designed is 127 mm (5 inches) in diameter and 0.5 m long. It can generate 74.5 kN vibratory force at the frequency of 150 HZ compared to 100 kN for the SHD. The drill string transfers rotary and vibratory motion to a drill bit. Drill string vibration is a very prevalent phenomenon: it has a great effect on drilling engineering, and drill string resonance is the main reason causing drill string fatigue. The drill string is connected to the vibration generation device proposed in this study, and it is another purpose of this study to analyze the effect of vibration on the drill string. Possible solutions are explored on how a shock sub can be used to mitigate a vibration generated by a vibratory tool or by bit rock interaction. In this regard, a model of the drill string is generated for real oil drilling at higher depth in commercial simulation software. This model includes self-weight, buoyancy forces due to the drilling fluid and realistic boundary conditions. This drill string model is used to predict the vibration tool force transmission to the rock and to the surface. This model is then used to design isolators to mitigate the vibration transferred to the surface. The result of this analysis shows that weight on bit (WOB), damping and spring constant of a shock sub have strong effects on the amplitude of vibration for the surface equipment. By applying higher WOB, damping and spring constant this amplitude would be reduced dramatically.


identifier: Jerome, David Kenneth <https://research.library.mun.ca/view/creator_az/Jerome=3ADavid_Kenneth=3A=3A.html>   (2012) The role of L-type calcium channels in early odor preference learning.  Masters thesis, Memorial University of Newfoundland.

abstract: These experiments provide evidence that L-Type Calcium Channels (LTCCs) are present in the neonate rat olfactory bulb, and that they are involved in the formation of early olfactory preference memories. Immunohistochemistry staining demonstrated that LTCCs arc present in the olfactory bulb, with the highest concentration observed on mitral cell apical dendrites, and on periglomerular cells. Inhibition of LTCCs was sufficient to block early odor learning induced by an intrabulbar infusion or β-adrenoceptor agonist isoproterenol. Stimulation of LTCCs in the olfactory bulb was not sufficient to induce an early olfactory learning event, but did succeed in rescuing isoproterenol-induced learning from a block of the NMDA receptor. Finally, an NMDA receptor block, but not LTCC block, was necessary to prevent learning induced by an infusion of the GABA receptor antagonist gabazine. These results support the theory that LTCCs contribute to the conditioned stimulus of early olfactory learning via the influx of calcium into the cell.


identifier: Johar, Pramod <https://research.library.mun.ca/view/creator_az/Johar=3APramod=3A=3A.html>   (2012) Effects of rapid and slower rotations to an inverted seated posture on human neuromuscular and cardiovascular functions.  Masters thesis, Memorial University of Newfoundland.

abstract: An inverted body posture is not common. During unusual situations (e.g. overturned helicopters or motor vehicle accidents) when the body is inverted, the neuromuscular responses can change. In order to manage these situations, it is necessary to examine changes in muscle force output and activation. -- Although the exact mechanisms are unknown, it is believed that both central And peripheral factors can contribute to changes in muscle force output. Increase in cerebral blood pooling, increase in hydrostatic pressure, and decrease in sympathetic activity during rapid and slow transitions from upright to inverted seated position are considered to be the main central factors leading to decrease in inversion-induced muscle force output. Peripheral factors such as decreased blood flow to the contracting muscle resulting in decrease perfusion pressure and oxygen deficit within the muscle are most likely to summate along with central factors inducing neuromuscular impairments during rapid and slower inversion rotations. -- There is no evidence examining possible impairments in neuromuscular functioning with more rapid versus slower inverted rotations as compared to an upright seated position. Maximal voluntary contraction (MVC) and electromyographic (EMG) activity were recorded and analyzed in biceps and quadriceps, concurrently and individually, for maximal force output and activation with upright seated position, and inverted within 1s and 3s rotations. It was anticipated that changes in muscle force and activation within 1s and 3s inversion rotations would suggest impairments in the functioning of neuromuscular system, as compared to the upright position. In addition, heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were also recorded. -- Both biceps and quadriceps exhibited significant decreases in maximal voluntary force and EMG activity, both concurrently and individually, when inverted within 1s and 3s rotations compared to an upright position.  HR, SBP, and DBP also demonstrated significant decreases when inverted within 1s and 3s rotations compared to upright position. This suggests both rapid and slower inversion impairs neuromuscular function.


identifier: Johnston, Matthew Joel <https://research.library.mun.ca/view/creator_az/Johnston=3AMatthew_Joel=3A=3A.html>   (2012) Controls on variability of mudstone mineralogy.  Masters thesis, Memorial University of Newfoundland.

abstract: The primary aim of this work is to investigate heterogeneity in the mineralogical composition of mudstones resulting from input (detrital, production and diagenetic) variability. With this aim four formations were examined with three unique investigations. -- Heterogeneity as a result of diagenesis in the Exshaw Formation (Devonian-Carboniferous) was investigated with a focus on the sulfur cycles influence on mudstone composition. Heterogeneity related to the carbon cycles influence on source and reservoir characteristics of mudstones was analyzed by comparing two carbonate-rich mudstone units (i) the Utica Shale (Ordovician) and (ii) the Winterhouse Formation (Ordovician). The Benbulben Shale (Devonian-Carboniferous) was utilized as a natural laboratory to investigate the scale of heterogeneity in mudstones. -- Accurately evaluating fine-grained rocks requires investigating rock properties on a sub-centimetre scale; therefore in all formations lithofacies variability was measured with both petrographic (transmitted light, SEM) and geochemical methods (XRD, XRF, TOC and δ¹³C  in addition to field logging.


identifier: Kavanagh, Mark B.(Mark Bradley) <https://research.library.mun.ca/view/creator_az/Kavanagh=3AMark_B=2E=28Mark_Bradley=29=3A=3A.html>   (2012) A fast, physically-based subglacial hydrology model applied to the North American ice complex over the last glacial cycle.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Kenney, Jessica L.(Jessica Lynn) <https://research.library.mun.ca/view/creator_az/Kenney=3AJessica_L=2E=28Jessica_Lynn=29=3A=3A.html>   (2012) Assessing and minimizing fillet discoluration in commercially harvested yellowtail flounder (Limanda ferruginea).  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Khalifa, Mohamed <https://research.library.mun.ca/view/creator_az/Khalifa=3AMohamed=3A=3A.html>   (2012) Optimal risk-based inspection and maintenance (RBIM) planning for process assets.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Process assets are subjected to deterioration during operation. Inspection is carried out at pre-defined intervals and at prescribed locations. This monitoring strategy is needed to ensure that all assets perform their intended functions and that plant integrity is not threatened. Based on the outcomes of the inspection, a maintenance decision such as repair or replacement is made. -- This thesis developed a framework for optimal risk-based inspection and maintenance planning for process assets subjected to fatigue and corrosion. This framework includes two main parts: -- Inspection sampling: This part aims at estimating the required size of the inspection sample for assets/systems subjected to general corrosion and localized corrosion such as stress corrosion cracking, hydrogen induced cracking and pitting corrosion. -- Optimization of the risk-based inspection and maintenance (RBlM) plan: This part aims at determining the optimal inspection interval, inspection technique and maintenance activity (repair, replacement and/or alteration). -- In the first part of the framework, the required sample size is estimated to assss general and localized corrosion of process assets/systems. In the case of general corrosion, a Bayesian approach-based method is proposed for calculating the required sample size. The proposed method ensures that the error in the posterior estimate of the mean metal loss due to general corrosion does not exceed a pre-defined acceptable margin of error at a specified confidence level. An analytical formula to estimate the sample size is introduced. The sample size obtained using the proposed method is smaller than a sample size obtained using the classical method with the same confidence level. This reduces sampling inspection cost without affecting the precision of the estimate. -- In the case of localized corrosion, a different methodology is proposed to estimate the required sample size. The proposed methodology uses the extreme value and bootstrap methods. This methodology ensures that the predicted maximum localized corrosion using the extreme value method is within an acceptable margin of error at a specified confidence level. Two closed-form formulas are proposed for calculating the sample size in case of localized corrosion. The two formulas address the both situations when prior information is available or unavailable. A Bayesian updating approach is used to update prior information obtained from previously performed inspections and engineering judgement. -- In the second part of the framework, a methodology for the optimal selection of an RBIM plan is proposed. This methodology is comprised of the following main steps: classification of asset's components/areas according to criticality of deterioration, asset deterioration modeling, risk assessment, cost estimation (inspection and maintenance) and finally the selection of optimal inspection intervals and a maintenance strategy. To solve the optimization problem, an objective function is formulated as a function of the present value of inspection cost, repair/replacement cost, risk of failure and the remaining value of the asset after a specified period of time. The selection of the optimum inspection interval, inspection technique and maintenance activity is based on minimizing the objective function subject to a safety constraint that the risk of failure over the lifetime of the asset does not exceed an acceptable level. The proposed methodology allows for a minimization of the inspection and maintenance cost over the lifetime of a deteriorated asset/system without compromising the safety. -- The developed RBIM framework will help operators to make well informed decisions, which will result in cost effective asset integrity management and a higher level of safety.


identifier: Khorshidian, Hossein <https://research.library.mun.ca/view/creator_az/Khorshidian=3AHossein=3A=3A.html>   (2012) Phenomena affecting penetration mechanisms of polycrystalline diamond compact bits.  Masters thesis, Memorial University of Newfoundland.

abstract: A drill setup is prepared to study the influence of borehole pressure and bit hydraulics on the performance of a drill bit. -- Experimental study of bit-rock interaction shows that the negative influence of the borehole pressure on penetration mechanisms of polycrystalline diamond compact (POC) bits, in addition to the rock strengthening under elevated borehole pressure, is the accumulation of cuttings in between the face of cutters and rock surface in the zone of penetration. -- The flow of cuttings on the surface of the cutter, results in applying a confining pressure on the zone of penetration. This confinement causes a considerable rock strengthening in the zone of penetration, which increases the mechanical specific energy and reduces the rate of penetration. The value of the confinement is observed to be related to the coefficient of friction between the cutter and cuttings and the geometry of the rockcutter interaction. -- On the other hand, utilizing a bit with an appropriate jet flow significantly improves the performance of the bit. However, the experimental results indicate that there is an optimum condition for applying the hydraulic power on the bit, which yields maximum drilling efficiency. -- In addition, in a simulation of a single POC cutter-rock interaction, using the distinct element method, it has been found that there is an optimum condition for vibrations of the bit which results in the minimum energy of penetration. The optimum condition of the cutter oscillation can be defined in terms of vertical displacement amplitude and vertical velocity amplitude of the  cutter while it is moving horizontally. These parameters can be changed by adjusting inertia of the cutter with respect to the horizontal speed of the cutter.


identifier: King, Heather Dawn <https://research.library.mun.ca/view/creator_az/King=3AHeather_Dawn=3A=3A.html>   (2012) Remote wilderness cabins on the Avalon Peninsula: male spaces and culture.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Javaheri Koupaei, Amir.H.(Amirhossein) <https://research.library.mun.ca/view/creator_az/Javaheri_Koupaei=3AAmir=2EH=2E=28Amirhossein=29=3A=3A.html>   (2012) Numerical modelling and inversion of borehole induced polarization data.  Masters thesis, Memorial University of Newfoundland.

abstract: The classical borehole Induced Polarization (IP) for mineral exploration is using a lateral probe where the two potential electrodes and one current electrode are deployed in one probe and used to measure the voltage in the drill-hole while the other current electrode is placed on the ground at infinity. Classical borehole IP has several limitations including an investigation radius that is restricted by borehole depth, depth of measurements limited by borehole depth, sensitivity to in-hole mineralization ,and data are not suited to 3D inversion. In the first part of this thesis, numerical modelling and inversion methods for the measurements of a novel IP borehole survey design have been investigated. The new survey design called, hole-to-hole lP, has been introduced by Abitibi Geophysics and aims to compensate the limitations of classical borehole IP especially in providing data that are suitable for 3D modeling and inversion. The geophysical modelling package "DCIP3D" provided by Geophysical Inversion Facility of the University of British Columbia has been used for forward modelling and inversion of hole-to-hole IP data. Different combinations of receivers and boreholes have been examined to obtain the economically optimum survey design including the minimum number of boreholes and receiver locations for a successful imaging of the chargeable ore body in a mineral exploration project. Also, a weighting function has been applied to improve the imaging of the mineral deposit located between boreholes. In the second part of the thesis, a 3D numerical modeling techniques based on integral equation methods for modelling of DC resistivity and IP data has been developed. The pivotal novelties in the code are, first, the application of unstructured meshes which is more flexible to complicated geometry with respect to the structured mesh. Second, the 3D code has been developed to allow both constant and linearly variable charge inside each cell and this enables us to simulate the charge accumulation over the boundary surface more precisely. Therefore, the developed code will enable numerical modelling to be done for more complicated ore bodies than was previously the case.


identifier: Li, Shuo <https://research.library.mun.ca/view/creator_az/Li=3AShuo=3A=3A.html>   (2012) Association of MTHFR and 9p21 with ischemic stroke in the Chinese Han population.  Masters thesis, Memorial University of Newfoundland.

abstract: Previous studies have revealed inconsistent results in examining the association of MTHFR c.677C>T, c.1298A>C variants and 9p21 locus with ischemic stroke. This thesis includes two case control studies by enrolling 1,429 ischemic stroke patients and 1,197 control individuals from the Chinese Han population. One study validates the association between the candidate 9p21 locus and ischemic stroke both at the SNP and Haplotype levels by genotyping four common variants encompassing a 44kb candidate risk region on 9p21. Moreover, the haplotype analysis reduces the candidate risk region on 9p21 locus to 28 kb. The other study indicates that the MTHFR locus is associated with ischemic stroke in the Chinese Han population. The MTHFR c. 677C>T variant is a risk factor, and its effect could be modified by genetic or environmental factors which vary among different ethnic populations. The MTHFR c. 1298A>C variant is more likely to play the role of a genetic marker than a causative variant in association with ischemic stroke. Combined analysis suggests the 9p21 locus and MTHFR risk alleles confer an additive co-effect for increased risk in ischemic stroke.


identifier: Liang, Shuai <https://research.library.mun.ca/view/creator_az/Liang=3AShuai=3A=3A.html>   (2012) Reversible dispersion and releasing of single-walled carbon nanotubes by stimuli-responsive TTFV-Phenylacetylene Polymers and their derivatives.  Masters thesis, Memorial University of Newfoundland.

abstract: Carbon nanotubes (CNTs) have drawn considerable research attention owing to their unique properties and wide spectrum of applications in materials science. However, most applications of carbon nanotubes are still in preliminary stages due to the poor processibility of CNTs (e.g., low solubility and strong aggregation). To overcome this barrier, a class of tetrathiafulvalene vinylogues (TTFY) and phenylacetylene based conjugated polymers were designed and investigated. The polymer backbone can reversibly fold and unfold under the control of redox and acid/base stimuli. This conformational switching property has allowed the polymer to reversibly disperse and release single-walled carbon nanotubes (SWNTs) in organic solvents in a controlled manner, which in turn opens a new avenue for recyclable and non-destructive SWNT processing techniques. In addition, a series of TTFY polymers with various side chains were synthesized for comparative studies to understand the effect of polymer structure on the supramolecular interaction with SWNTs.


identifier: Linegar, Anna Elizabeth <https://research.library.mun.ca/view/creator_az/Linegar=3AAnna_Elizabeth=3A=3A.html>   (2012) Palaeo-environmental history of the southwestern Black Sea during the late Holocene: an elemental and stable isotopic study.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Lysenko, Ekaterina <https://research.library.mun.ca/view/creator_az/Lysenko=3AEkaterina=3A=3A.html>   (2012) Labour market development in Newfoundland and Labrador: regional challenges and active solutions.  Masters thesis, Memorial University of Newfoundland.

abstract: High unemployment in Newfoundland and Labrador for a long time has been associated with a lack of employment opportunities. However. the situation has changed - provincial labour market is now challenged by lack of workers. Despite a quick adjustment in large urban centers, rural areas of the province continue to be challenged by a high unemployment. although now it co-exists with a growing demand for labour. Such coexistence indicates geographical and skills mismatch between labour supply and demand. This thesis takes a ease study approach 10 examine implementation of Active Labour Market Policies (ALMP) in Newfoundland and Labrador and in Norway.  ALMP are aimed to stimulate adaptation of labour force to changed labour demand. The research attempts to asses to what extent the labour market policy in Newfoundland and Labrador has shifted towards ALMP, and whether this shift can be complimented by a successful ALMP transferred from another jurisdiction, with respect to –place-specific factors in both case studies.


identifier: Ma, Yue <https://research.library.mun.ca/view/creator_az/Ma=3AYue=3A=3A.html>   (2012) Lactational changes in the bone metabolism of mice lacking one copy of the calcitonon receptor gene.  Masters thesis, Memorial University of Newfoundland.

abstract: Calcitonin plays a critical role in preventing excessive bone resorption during lactation. Mice lacking both copies of the calcitonin (CT) gene (CT null mice) lose 55% of bone mineral content (BMC) or twice the amount of wildtype mice during lactation. The calcitonin receptor (CTR) is expressed in the pituitary, lactating breast tissues and bone in mice. However, at which of the three tissues and through which mechanisms the calcitonin acts on CTR to regulate calcium metabolism during reproductive periods are still unclear. This project assesses mice lacking one copy of a CTR gene as a means to understand whether loss of CTR has the same phenotype as the loss of CT during the reproductive cycle. If so, it would enable more studies into the detailed mechanisms of how calcitonin works in each tissue during the reproductive period. --  Wildtype (WT) and heterozygous Ctr gene-deleted sisters (Ctr⁺/⁻) were used to compare BMC changes during pregnancy and lactation using the PixiMus DXA bone densitometer. Ctr null mice cannot be studied because they usually die prior to birth. Urine, serum and milk were collected and analyzed for the mineral content, bone formation, bone resorption markers, and parathyroid hormone (PTH). DXA scanning and urine/serum collections occurred at baseline (before pregnancy), late pregnancy, late lactation, and days 7, 14 and 21 of post-weaning recovery. Tibias were analyzed separately by microcomputed tomography (μCT), the 3-point bend test, and real-time quantitative RT-PCR for Ctr gene expression. -- WT and Ctr⁺/⁻ mice experienced typical lactational changes of BMC and bone microstructure and recovered quickly and fully to baseline levels after weaning. WT and Ctr⁺/⁻ females lost 10.7% ± 3.4% and 10.6% ± 2.0% BMC during lactation relative to baseline level respectively. No significant difference in BMC was observed between WT and Ctr⁺/⁻ mice at any time point. Urine calcium, phosphorus and magnesium levels changed appropriately during reproduction with no significant differences between WT and Ctr⁺/⁻, except for significantly lower urine phosphorus (11.0 ± 2.2 of WT vs. 4.4 ± 1.4 of Ctr⁺/⁻, p < 0.05) and a trend for lower urine calcium and magnesium in Ctr⁺/⁻ at late pregnancy. Bone turnover was increased in both genotypes at late lactation and early recovery. PTH showed an increasing trend from baseline to late lactation. Milk calcium content was the same in both genotypes. Bone strength was significantly decreased at late lactation with no difference between genotypes. WT and Ctr⁺/⁻ had equal levels of Ctr mRNA expression in the tibia. -- In summary, WT and Ctr⁺/⁻ underwent similar changes in bone mass, bone  microarchitecture, calciotropic hormones, and serum and urine minerals during pregnancy and lactation. After lactation, the skeleton of each genotype recovered fully and quickly. Loss of one copy of the calcitonin receptor gene does not cause the same phenotype as complete loss of the calcitonin gene (Ctcgrp) likely because one allele transcription of Ctr gene compensates.


identifier: Malone, Meaghan <https://research.library.mun.ca/view/creator_az/Malone=3AMeaghan=3A=3A.html>   (2012) Jane Austen's balls : the dance of masculinity.  Masters thesis, Memorial University of Newfoundland.

abstract: While several scholars have recently offered analyses of male sexuality in Jane Austen's novels and others have examined the gender dynamics of her scenes of dance, there is no extensive study of masculinity as developed in Austen's ballrooms. Focusing specifically on Austen's scenes of dance, this thesis analyzes the ways in which masculinity and the male body are presented in each of her six major works. Reconciling conflicting late eighteenth- and early nineteenth-century debates regarding masculinity, Austen creates heroes who are at once historically contingent and surprisingly modern. Her scenes of dance are at the narrative heart of each of her novels, and become opportunities for Austen to bring the body to the foreground. Her characters read each other through their bodies, and the male body is explicitly appraised in a society where sexuality is inextricably linked to visuality. Filtered through the eyes of Austen's female characters, the male body becomes an object of female scrutiny as Austen highlights the social and sexual power of the female gaze. Masculinity is consequently fully embodied in each of Austen's novels, and she presents dance as a man's means of self-fashioning. Moreover, the masculine ideal that Austen creates via the female gaze facilitates reciprocity between heroine and hero, and requires his response and adaptation to her expectations of what a man "ought to be."


identifier: Martin, Chris William <https://research.library.mun.ca/view/creator_az/Martin=3AChris_William=3A=3A.html>   (2012) Tattooed minds : expressing the self through shapes and lines.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: McGrath, Gerald Shane <https://research.library.mun.ca/view/creator_az/McGrath=3AGerald_Shane=3A=3A.html>   (2012) The safety of anti-tumor necrosis factor-alpha agents used for the treatment of inflammatory bowel disease: a systematic review and meta-analysis.  Masters thesis, Memorial University of Newfoundland.

abstract: Background. Anti-tumor necrosis factor alpha (anti-TNF-α) therapy is used to treat inflammatory bowel disease. Infrequent but serious adverse events related to these medications have occurred. -- Objective. The aim of this meta-analysis is to evaluate the safety of anti-TNF-α agents in patients with inflammatory bowel disease (IBD). -- Methods. Randomized trials that evaluated an anti-TNF-α agent (infliximab, adalimumab, certolizumab, etanercept, COP 571 and onercept) for the treatment of IBD were included. The studies had to report on safety and tolerability. Trials were identified by searching electronic databases and the data were analyzed using the Cochrane review manager (RevMan 5.1) software. -- Results. Twenty four studies were included in the meta-analysis. There was no statistical difference in the frequency of withdrawal due to adverse events, serious infections, death, malignancies or tuberculosis between anti-TNF-α and placebo groups. Placebo patients were more likely to experience a serious adverse event than patients treated with an anti-TNF-α agent. Patients treated with anti-TNF-α agents were more likely to develop pneumonia or experience an infusion reaction than placebo patients. There were no reports of opportunistic infections, congestive heart failure, or demyelinating disease, for any of the agents studied. However, post marketing surveillance has shown that patients are at an increased risk of opportunistic infections. Adverse events with anti-TNF-α agents were noted to occur irrespective of the indication. -- Conclusion. Overall, the results of this meta-analysis demonstrate that the use of anti-TNF-α agents is safe for patients with IBD.


identifier: Mehfuz, Omit <https://research.library.mun.ca/view/creator_az/Mehfuz=3AOmit=3A=3A.html>   (2012) Metals recovery from waste solution using bioadsorbents derived from biomass wastes.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Alemzadeh Mehrizi, Arezoo <https://research.library.mun.ca/view/creator_az/Alemzadeh_Mehrizi=3AArezoo=3A=3A.html>   (2012) Analysis of interferon-inducible gene expression following ras.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Melanson, Alexandre <https://research.library.mun.ca/view/creator_az/Melanson=3AAlexandre=3A=3A.html>   (2012) Numerical modelling of subglacial erosion and sediment transport and its application to the North American ice sheets over the last glacial cycle.  Masters thesis, Memorial University of Newfoundland.

abstract: In process


identifier: Midgley, Scott J.(Scott James) <https://research.library.mun.ca/view/creator_az/Midgley=3AScott_J=2E=28Scott_James=29=3A=3A.html>   (2012) Co-producing ores, science and states: high arctic mining at Svalbard (Norway) and Nanisivik (Canada).  Masters thesis, Memorial University of Newfoundland.

abstract: Though much media and academic attention has been paid to recent Arctic resource development projects such as the Mary River project on Baffin Island (Canada), the extraction of resources from circumpolar regions is not a new phenomenon. In fact enclaves in the Arctic have been industrialized (and in some cases, deindustrialized) for some time now, and these operations have been no less intertwined in historical and contemporary Arctic geopolitics. Through an analysis of historical and contemporary documents complemented by key-informant interviews, this thesis presents historical-geographical research on two case studies - Svalbard (Norway) and Nanisivik (Canada) that provide valuable insight into the political economies of extractive activities in the Arctic. This thesis argues that the mines at Svalbard and Nanisivik were not simply economic projects intended to produce valuable ores, but were "co-productive" in the sense that they reproduced state territory and fulfilled political, geopolitical or geostrategic objectives. Furthermore, this thesis suggests that the operation of these mines was not characterised by a productive phase followed by a closure phase, but other activities such as scientific research have revalorized these mining landscapes, owing to the geographical, geostrategic and environmental importance of these Arctic sites.


identifier: Miller, Matthew Bruce <https://research.library.mun.ca/view/creator_az/Miller=3AMatthew_Bruce=3A=3A.html>   (2012) Understanding the effects of exercise on gut hormones & obesity.  Masters thesis, Memorial University of Newfoundland.

abstract: This study was designed to investigate the effects of a high-intensity circuit training exercise program on obese sedentary males, and circulating levels of pancreatic polypeptide. A total of 8 participants underwent an exercise intervention in which 12 exercise sessions over four weeks were completed. In each exercise session participants performed 7 resistance/body weight exercises in 3 circuits with as little rest as possible. Each week participants exercised 3 times and had blood work taken 2 times on alternating days. A dual-energy x-ray absorptiometry (DXA) scan was completed pre and post exercise program to measure body composition. The results indicated that the exercise program significantly changed the volume of work completed, resting heart rate, systolic blood pressure, body fat percentage, lean and fat tissue percentages, and trunk and leg fat percentages. There was no significant change in pancreatic polypeptide levels, diastolic blood pressure, time to completion, body mass, BMI, lean or fat body mass, or arm fat tissue. The results of this study indicate that 12 exercise sessions of a high intensity circuit training exercise program are safe (for an otherwise healthy obese male) and effective in changing body composition, decreasing cardiovascular risk factors and increasing strength.


identifier: Beiramzadeh Moghaddam, Reza <https://research.library.mun.ca/view/creator_az/Beiramzadeh_Moghaddam=3AReza=3A=3A.html>   (2012) Conducting polymers, metal oxides, and their effects on the oxidation of organic fuels at Pt or Pd.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The ideas explored in this thesis originate from the significant role of the support material in the performance of anodes in organic fuel cells. This text describes a variety of approaches to provide insight into the synthesis, structure, and roles of various supports in organic fuel oxidation at Pt or Pd. -- Potentiodynamic, potentiostatic, and galvanostatic regimes were used to polymerize pyrrole on carbon black (CB) electrodes. It was found that the electrochemical properties and structures of the CB/polypyrrole composites (PPCB) depended on the polymerization conditions. While potential-controlled polymerization regimes produced resistive PPCB films, constant current polymerization resulted in PPCB composites with high conductivity over a wide potential range. -- Potentiodynamic, potentiostatic, and galvanostatic regimes were used to polymerize pyrrole on carbon black (CB) electrodes. It was found that the electrochemical properties and structures of the CB/polypyrrole composites (PPCB) depended on the polymerization conditions. While potential-controlled polymerization regimes produced resistive PPCB films, constant current polymerization resulted in PPCB composites with high conductivity over a wide potential range. -- A methodology was developed to study support effects, based on the use of polyaniline (PANI) or various metal oxides (MOs) on glassy carbon (GC) as supports for organic fuel oxidation at Pt and Pd nanoparticles. Methanol oxidation at a GC/Ru oxide/Pt electrode was compared to GC/Pt, while a GC/PANI/Pt electrode did not show any enhancement. The same GC/PANI support (made in 0.1 M H₂SO₄), and also GC/PANI electrodes made in two other media (CF₃COOH and CF₃SO₃H), coated with Pd nanoparticles gave lower onsets and higher FA oxidation currents than at GC/Pd, providing unambiguous evidence for effects of PANI on this reaction at Pd. The method was further extended to ethanol oxidation at Pt supported on various MOs, where InSn oxide/Pt, GC/Ru oxide/Pt, GC/Sn oxide/Pt, and GC/RuSn oxide/Pt electrodes were superior to GC/Pt at all potentials. Sn oxide was effective at low potentials (E < +0.4 V/SCE), resulting in higher activities of the Sn oxide-containing electrodes over this range. At more positive potentials GC/Ru oxide/Pt gave superior activity due to the effectiveness of Ru oxide for CO oxidation.


identifier: Morrissey, Andrea Nicole <https://research.library.mun.ca/view/creator_az/Morrissey=3AAndrea_Nicole=3A=3A.html>   (2012) An examination of biologic treatment groups of psoriasis patients in a cohort of the Newfoundland and Labrador population.  Masters thesis, Memorial University of Newfoundland.

abstract: Objective: -- To examine psoriasis patients receiving biologic treatment by biologic treatment type, demographic factors and various prognostic factors. Also, to examine health service utilization and comorbid conditions among biologic patients. In addition, to determine the risk of developing specified comorbidities based on treatment type received. Finally, to examine whether or not biologic treatment is associated with an increased Charlson Comorbidity Index (CCI) score. -- Methods: -- In this cross-sectional study, psoriasis demographic, clinical and treatment data were linked to physician claims, hospital and mortality data to investigate health service utilization of psoriasis patients between 1995/96 and 2007/08. -- Results: -- Findings indicate that the majority of patients receiving biologic treatment had moderate/severe psoriasis. Among biologic patients, 63.7% had at least one hospital separation, and 96.3% had at least one physician visit. Female biologic patients had a higher number of mean comorbidities compared to males (9.53±2.77 versus 8.20±2.78, respectively, p<0.01), as well as a higher mean CCI score (2.37±1.54 versus 1.93±1.32, respectively, p=0.04). The odds of having a 'skin and sub-cutaneous disorder' diagnosis was found to be 10 times greater if the psoriasis patient is taking biologics versus not taking biologics [10.49 (confidence interval 1.41-78.18), p=0.02]. -- Conclusions: -- Biologic patients are likely to have moderate/severe psoriasis, and to utilize health services (both physician and hospital), more so than non-biologic patients. Female biologic patients appear to be at a greater risk of developing comorbid conditions than male biologic patients; therefore, different comorbidity and treatment monitoring may be necessary for males and females. Biologic patients are more likely to develop skin and sub-cutaneous disorders than non-biologic patients.


identifier: Murphy, Justin Raymond <https://research.library.mun.ca/view/creator_az/Murphy=3AJustin_Raymond=3A=3A.html>   (2012) The effects of high and low repetition resistance training on neuromuscular fatigue and recovery in children and adults.  Masters thesis, Memorial University of Newfoundland.

abstract: The major objectives for this thesis included: 1) determining the effects of high and low repetition resistance training on neuromuscular fatigue in children while utilizing one minute rest intervals, and 2) comparing the corresponding responses of children to adults. These objectives along with the integration of the known literature on fatigue and recovery in children will help develop appropriate standards with respect to rest intervals and resistance training in children. The existing literature on pediatric resistance training is scarce, but there are a few studies that indicate children recover quicker than adults. Despite this notion, it is important to understand why children recover quicker, or why a child's body has a tendency not to fatigue to the same extent as an adult. The present study determined that children are more likely to exhibit decrements in performance due to problems with muscle coordination as oppose to neuromuscular fatigue. In addition, decreased ratings of perceived exertion may suggest that children may not put forth a maximum effort to the same intensity as an adult. As expected, children were reported to recover faster than the adults during both RT protocols.


identifier: Newby, Dalyce <https://research.library.mun.ca/view/creator_az/Newby=3ADalyce=3A=3A.html>   (2012) An examination of the orientation needs of international students at the Humber College Institute of Technology & Advanced Learning.  Masters thesis, Memorial University of Newfoundland.

abstract: The purpose of this study was to: (a) clarify the meaning, of "orientation", (b) evaluate effectiveness of the international student orientation program, (c) determine whether the program, met the needs of the survey respondents, and (d) ascertain the most appropriate method for the delivery of the pre-departure materials, and ideal schedule for the on-site orientation program. The research study was conducted at the Humber College Institute of Technology and Advanced Learning, in Toronto, Ontario. -- A convenience sample was used, drawing respondents from the 2006-2007 academic cohort. The respondents were asked to complete a web-based survey. From the study's findings, the respondents equated the term "orientation" as the means for learning more about Humber and it services. They indicated that the two primary resources they used for their pre-departure preparation were: (a) viewing the Humber international student website, and (b) dialoguing with family, friends and alumni. Their primary orientation needs were consistent with the basic needs addressed in Maslow's Hierarchy of Needs theory. It was found that the respondents preferred to continue to receive pre-departure materials through regular mail, and that the scheduling of the on-site orientation remain the same. The data results were discussed, and recommendations for program improvements and future research were provided.


identifier: Palleboina, Dharamaraju <https://research.library.mun.ca/view/creator_az/Palleboina=3ADharamaraju=3A=3A.html>   (2012) Solid-state NMR studies of lung surfactant protein-B fragments in model and natural lung surfactant lipid bilayers.  Masters thesis, Memorial University of Newfoundland.

abstract: Lung surfactant, a membranous lipid-protein complex, prevents lung collapse by lowering the surface tension at the alveolar air-water interface. Surfactant protein B (SP-B) is an essential component of lung surfactant and is indispensable for life. Mini-B is a two-helix fragment of SP-B that retains significant biological activity compared to the full-length SP-B Solid-state ²H-NMR and ³¹P-NMR were used to characterize the lipid interactions of Mini-B or the combination of the SP-B C-terminal and N-terminal fragments (SP-BCTERM + SP-BNTERM) in mechanically oriented and multilamellar vesicle (MLV) lipid bilayers. These were composed of a model surfactant system, POPC-d₃₁/POPG (7:3) or a natural surfactant system, DPPC-d₆₂-doped Bovine Lipid Extract Surfactant (BLES). Our results show that Mini-B or SP-BCTERM + SP-BNTERM tends to disrupt the bilayer structure and induce the formation of a non-oriented fraction in oriented lipid bilayers on large-scales. Mini-B had a greater effect on oriented bilayers of POPC-d₃₁/POPG than did SP-BCTERM + SP-BNTERM. On the other hand, SP-BCTERM + SP-BNTERM showed more effect on oriented bilayers of BLES than did Mini-B. Neither peptide system significantly changed lipid orientational order in POPC-d₃₁/POPG, whereas the combination of SP-BCTERM + SP-BNTERM did induce some ordering in the oriented fraction of BLES. The interactions of these peptide systems with MLVs were studied in order to separate effects on chain order from large length scale perturbations of bilayer orientation. Neither peptide system induced formation of rapidly tumbling structures in POPC-d₃₁/POPG vesicles whereas both did, to a small extent, in BLES vesicles.  Modification of bilayer orientation in oriented lipid bilayers in presence of peptide may be relevant to the transfer of material from bilayer reservoirs to a flat surface active layer, a process that likely requires contact facilitated by the formation of highly curved protrusions. Despite its significant biophysical activity compared to full-length SP-B, Mini-B was not found to enable the formation of tubular myelin, a structure thought to be a precursor to the surface-active layer at the air-water interface.


identifier: Peckford, Genieve <https://research.library.mun.ca/view/creator_az/Peckford=3AGenieve=3A=3A.html>   (2012) Headed in the right direction: start point orientation and direction learning in rats.  Masters thesis, Memorial University of Newfoundland.

abstract: When trained to locate a hidden platform in a T-maze moved between two positions, rats appear to adopt a conditional strategy based on start point. To determine if location cues or orientation cues at the start point underlie this discrimination rats were trained from two maze positions to swim in a consistent direction from the choice point to the platform. When the maze was later moved to two new positions, rats required to make the same response based on start point orientation showed no disruption in performance while rats required to make the same response based on start point location did show an initial disruption in performance (Experiment 1). Animals explicitly trained to use start point location cues in Experiment 2 took significantly longer to solve a spatial task than rats trained explicitly to use orientation cues. When the start point location cues were masked, by making the room dark prior to placing the rats in the maze, performance did not deteriorate if rats were required to respond based on orientation of the start point but was disrupted if they were required to respond based on start point location cues (Experiment 3). This sense of direction requires exposure to the room cues to get oriented, as rats brought into an already darkened room (Experiment 4) were disrupted regardless of whether responses were tied to orientation cues or location cues. These findings are consistent with views of spatial learning that attribute a strong role to a rats' sense of direction. However, lesions to the anterior dorsal nucleus of the thalamus, a component of the head direction cell circuit, produced only transient deficits in direction learning in the water maze and small errors in heading on a foraging task.


identifier: Pittman, Andrea Nicole <https://research.library.mun.ca/view/creator_az/Pittman=3AAndrea_Nicole=3A=3A.html>   (2012) L-type calcium channels modulate firing patterns of ventral tegmental area neurons.  Masters thesis, Memorial University of Newfoundland.

abstract: Neurons originating in the ventral tegmental area (VTA) have been implicated in disease states such as drug addiction and schizophrenia. It is believed excessive dopamine transmission (via dopaminergic neuron excitation) underlies both disease states. As dopamine is released because of action potential firing, more intense spiking will result in more neurotransmitter being released. Therefore, understanding the mechanisms modulating firing patterns may lead to a better understanding of such diseases. -- This thesis seeks to compare the basic electrophysiological properties of dopaminergic (DAergic) and GABAergic neurons within the VTA, as well as to identify how L-type calcium channels (LTCC) modulate firing patterns of both cell populations. Using a mouse model with green fluorescent protein labeled DAergic neurons, combined with patch clamp recordings, I find two commonly used fingerprinting criteria, Ih current and dopamine autoinhibition, are specific to DAergic neurons. As well, using an LTCC transgenic mouse model and various LTCC modulators, I show LTCC activation modulates burst firing similarly in DAergic and non-DAergic neurons of the VTA. More specifically, the Cav1.3 subtype is responsible for this LTCC induced bursting. -- Understanding the intrinsic modulators of firing pattern regulation in both DAergic and non-DAergic neurons of the VTA can provide a better understanding of disease states associated with dopamine transmission dysregulation, potentially leading to a target for future treatment options.


identifier: Pius, James <https://research.library.mun.ca/view/creator_az/Pius=3AJames=3A=3A.html>   (2012) A novel approach to characterize the membrane disrupting activity of antimicrobial peptides using ²H solid-state NMR of whole Escherichia coli.  Masters thesis, Memorial University of Newfoundland.

abstract: Antimicrobial peptides (AMPs) are ubiquitous molecules that can display antimicrobial activity against bacteria, viruses, protozoa and various other pathogens. They are commonly short, cationic amphipathic peptides that may offer valuable bases for the development of new therapeutic agents. AMPs can have diverse mechanisms of antibacterial activity; all these mechanisms involve interacting with the bacterial membrane to some degree. In order to better understand these mechanisms, a variety of biophysical techniques including solid-state NMR (SSNMR) have been used to study AMPs in model lipid systems. However, these simple model systems do not reflect the complexity of whole cells with which AMPs interact in vivo. In order to bridge the gap between SSNMR studies of AMPs in model membranes and the true biological context of AMPs, a procedure was developed which incorporates high levels of ²H NMR labels specifically into the cell membrane of Escherichia coli. Using these labeled cells, ²H NMR spectra were acquired both in the absence and presence of the AMP MSI-78. The effects of MSI-78 on bacterial membrane disorder were quantified in terms of the first moment of the spectrum, which directly reflects the activity of MSI-78 in disrupting the membranes of whole bacteria. Data obtained from NMR measurements show an increased disorder in the orientation of lipids in the cell with increasing levels of MSI-78. These effects are observed at molar peptide:lipid (P:L) ratios 30 times greater than that used for model lipid systems and 25 times less than the ratios needed to inhibit cell growth. Based on the observed results, MSI-78 can disrupt the lipid order in the cell envelope even at sublethal concentrations.


identifier: Porter, Robert Neil <https://research.library.mun.ca/view/creator_az/Porter=3ARobert_Neil=3A=3A.html>   (2012) Patterns of interventions for analgesia for children presenting to a pediatric emergency department with supracondylar humerus fracture.  Masters thesis, Memorial University of Newfoundland.

abstract: Objective: To describe practice patterns for analgesic treatment in children presenting with supracondylar humerus fracture to the Janeway Children's Health and Rehabilitation Centre Emergency Department (ED) in the Canadian Province of Newfoundland and Labrador. -- Design: Retrospective cohort study. -- Methods: A consecutive sample of 160 children treated by emergency physicians for supracondylar humerus fracture at the Janeway ED was obtained.  Injuries were classified as non-severe or severe, and cases were compared with respect to analgesic measures undertaken. -- Results: The proportion of children treated with an analgesic at any time during their ED visit was 35% (57 cases). Severe cases were more likely to be given an analgesic than non-severe. Treatment with an analgesic early in the visit was very uncommon. -- Conclusion: Timely analgesic trretment in the ED for children with supracondylar fracture is low, even for more severe injuries. A multi-faceted approach to this problem is required.