identifier: Daniels, Rebecca Elizabeth <https://research.library.mun.ca/view/creator_az/Daniels=3ARebecca_Elizabeth=3A=3A.html>   (2013) Existence of a triple layered system of Ca-generators in swine purkinje cells.  Masters thesis, Memorial University of Newfoundland.

abstract: Background: Spontaneous electrical signals from cardiac Purkinje fibers trigger life threatening arrhythmias. This abnormal signaling was associated with increased spontaneous intracellular Ca²⁺ activity following myocardial infarction. The present study aimed to understand the Ca²⁺ cycling within the endoplasmic reticulum (ER) in Purkinje cells (Pcells) in the large mammalian heart. -- Methods: Immunofluorescence, electron microscopy, and fast confocal Ca²⁺ imaging were used with normal porcine Pcells, to examine the Ca²⁺ activity under various conditions including addition of specific agonist/antagonists of ER-Ca²⁺ channels. -- Results: Spontaneous Ca²⁺ activity was different between 3 distinct subcellular regions: 1) the "Near SL" region was in  close apposition with the sarcolemma (SL) and contained IP₃R₁; 2) the "SubSL" region, contained a thin layer of RyR ₃, and 3) the core region contained RyR₂. -- Conclusions: These results are consistent with the existence of 3 distinct layers of ER Ca²⁺ -generators in porcine Pcells, which highlights potential new mechanisms for Purkinje arrhythmogenicity.


identifier: Das, Tanmoy <https://research.library.mun.ca/view/creator_az/Das=3ATanmoy=3A=3A.html>   (2013) Automatic ship hull surface modeling and hydrodynamic optimization.  Masters thesis, Memorial University of Newfoundland.

type: Thesis NonPeerReviewed

abstract: Engineers have always been fascinated by the optimality of an objective function of interest. Hydrodynamicists in the ocean and naval architectural engineering field have always sought to improve the hydrodynamic performance of any floating structure. For a moving vessel, wave resistance is one of the most important properties of hydrodynamic performance, and it influences a ship voyage economically by significant effect on EHP or fuel consumption. Therefore, reduction in wave resistance of any ship will help in reducing fuel cost. -- The present study investigates the scope for optimization of ship hulls based on wave resistance by modifying their geometries. During modification, there are geometric constraints to be maintained required by design and operational criteria. -- The calculation of wave resistance is based on a numerical solution, where ship hull surface discretization is required. An automatic hull generation and discretization system was developed, where a table of offsets or general coordinates of ship hull can be used as input. Then, the process proceeds with the BFGS (Broyden-Fletcher-Goldfarb-Shanno) optimization algorithms integrated with three different hull geometry modification methods. MAPS Resistance Version 2.0 was utilized to calculate wave resistance (the objective function) inside the algorithm. -- An integrated program employing FORTRAN 90 was developed, which is able to represent a ship hull mathematically and graphically utilizing B-spline surface and IGES format, respectively. This system is also able to process an optimization algorithm with direct feedback from the resistance evaluation unit. It will produce different sets of modified ship hull shapes with improved wave resistance. Therefore, it can serve a variety of interests determined by needs of a project. -- Several types of ship hulls were developed and checked for geometric validation, and results were satisfactory. Two basic ship hulls (Wigley and Series 60 Hulls) were further investigated for their wave resistance coefficients with published experimental data, and the convergences of results were quite acceptable. The optimum hull forms obtained from the software show improved wave resistance with significant differences in coefficient of wave resistance (Cw) values for all the selected Froude numbers. This program has been prepared in such a way that it can be adopted to search for the minima of other objective functions.


identifier: D'Avignon, Genevieve <https://research.library.mun.ca/view/creator_az/D=27Avignon=3AGenevieve=3A=3A.html>   (2013) Using otoliths as natural tags to study stock structure and connectivity of Atlantic cod (gadus morhua) in Newfoundland and Labrador waters.  Masters thesis, Memorial University of Newfoundland.

abstract: Atlantic cod (Gadus morhua) stock structure and dynamics are complex and remain a challenge to effective management. Otoliths have the ability to record the elemental signatures of a cod's environment. My research investigated the use of otolith chemistry to identify cod stocks within Newfoundland and Labrador waters, and to track cod movements and connectivity within and between stocks. Laser ablation inductively coupled mass spectrometer A-ICP-MS analyses provided precise and accurate measures for magnesium, mangnanesen, strontium, and barium concentrations. At large spatial scale, otolith elemental signatures and mean growth rate offish were used to segregate cod into four spawning areas with 66-89% accuracy when the two closely related inshore sites were pooled. Elemental variations in the otoliths of cod in Newfoundland waters are associated with environmental and geographical conditions that enabled reassigning 89% of cod to their correct area at small spatial scale and the discrimination of inshore vs. offshore fish within the 3Ps stock complex. This study demonstrated that otolith chemistry shows great potential to identify the origin of cod and reconstruct inshore-offshore migrations, both important elements in managing fisheries.


identifier: Davis, Karelyn Alexandrea <https://research.library.mun.ca/view/creator_az/Davis=3AKarelyn_Alexandrea=3A=3A.html>   (2004) Statistical inference for normal means with order restrictions and applications to dose-response studies.  Masters thesis, Memorial University of Newfoundland.

abstract: Scientific experiments often compare several treatment means with a control mean. In particular, such multiple comparisons arise in biopharmaceutical studies in which it is desirable to conduct the inferences in a specified order and failure to achieve the desired inference at any step renders subsequent comparisons unnecessary. In clinical trials, an important dosing quantity is the minimum effective dose (MED), defined as the minimum dose such that the mean response is clinically significantly better than the mean response of the control by a practical significant difference. In relation to MED estimation, previous authors have either failed to account for the monotonicity of the dose-response means or considered the case of a zero clinically significant difference. In this thesis, an innovative approach using Kuhn-Tucker conditions to evaluate the optimal confidence lower bound at each step in a closed step-down testing procedure is derived and simulation results are presented.


identifier: Davis, Philip James <https://research.library.mun.ca/view/creator_az/Davis=3APhilip_James=3A=3A.html>   (1982) The thermotropic behavior of aqueous dispersions of mixed-acid lecithins.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Most phospholipids found in biological membranes are mixed-acid phospholipids.  Yet there is little known about the physical properties of mixed-acid phospholipids in bilayers. In this work positional isomers were synthesized using modifications of published procedures. Differential scanning calorimetry was used to study the thermotropic properties of aqueous dispersions of l-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine (OPPC), l-palmitoyl-2oleoyl-sn-glycero-3-phosphocholine (POPC), l-oleoyl-2-stearoyl-sn-glycero-3-phosphocholine (OSPC), l-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine (SOPC), l-oleoyl-2-arachidoyl-sn-glycero-3-phosphocholine (OAPC), and l-arachidoyl-2-oleoyl-sn-glycero-3-phosphocholine (AOPC). The gel to liquid-crystalline phase transition temperatures of these lecithins were different from each other, and from those of the parent single-acid lecithins. For each pair of positional isomers the isomer with the longer chain at the sn-l position had the lower transition temperature. – The thermotropic behavior of mixtures of cholesterol with four mixed-acid lecithins and three single-acid lecithins was studied using differential scanning calorimetry. Asymmetric endotherms were observed, and these were resolved into a narrow and a broad component. The narrow components disappeared at different levels of cholesterol for the different lecithins. The results suggested that for the OSPC-SOPC pair, cholesterol interacted more with OSPC than with SOPC. For the OAPC-AOPC pair, the interaction was greater between AOPC and cholesterol than between OAPC and cholesterol. Structural differences in the hydrocarbon region of the lecithin bilayers may account for these observations. – Phase diagrams were constructed for mixtures of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) with some mixed-acid lecithins. The phase diagrams were analyzed using Regular Solution Theory, and excess interaction energies were obtained. – Gel phase immiscibility was observed in the mixtures of DPPC with OPOC and with SOPC, but not in mixtures of DMPC with POPC or with l-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine. The miscibility in the gel phase appeared to be related to the transition temperatures of the lipids. In the liquid-crystal there was complete miscibility in all four mixtures. The estimates of excess interaction energies suggested that transient clusters of like molecules in the liquid-crystal may occur. Computer simulations based on excess interaction energies were also presented.


identifier: Davison, Robert L. <https://research.library.mun.ca/view/creator_az/Davison=3ARobert_L=2E=3A=3A.html>   (2004) In defence of corporate competence: the Royal Navy executive officer corps, 1880-1919.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: At the end of the nineteenth century the Executive Officer Corps of the Royal Navy faced significant challenges as it dealt with social, economic, political and technological change. Although rising international tension appeared to benefit the service as a whole, changes in force structure and organization presented threats to the professional competence of executive officers. Increased expenditure on defence and increasing public scrutiny was combined with the growth of other developing professions, especially engineering, that challenged older lines of authority. Also, the advance of education and skill of ratings and non-executives weakened the traditional claims by the executive officer corps to leadership over the lower deck and other branches of service. The corps attempted to deal with these issues by asserting its dominance in changing career patterns, finding new intellectual justification for the continued "culture of command" through the advent of modem naval history, and the institution of new, more efficient staff command systems. The corps also attempted to annex engineering functions through the Selbome education scheme of 1902. The outbreak of World War I in 1914, presented the corps with the hazardous task of justifying itself and making good on its claims to dominance within the establishment. Despite the setbacks and disasters of war, the corps largely managed to retain its dominance into the interwar period.


identifier: Dawe, Roland A. <https://research.library.mun.ca/view/creator_az/Dawe=3ARoland_A=2E=3A=3A.html>   (1983) A study of evaluation systems for school principals in the province of Newfoundland and Labrador.  Masters thesis, Memorial University of Newfoundland.

abstract: The purpose of this study was to examine principal evaluation systems available in Newfoundland and Labrador and make proposals for future development in this area. More specifically, this study attempted to answer the following questions: -- 1. How many school boards in the Province have developed formal systems for the evaluation of principals? -- 2. What are the major characteristics of these systems, in accordance with the following elements: -- Purposes; Criteria; Procedures; including evaluators, instruments, and processes used. -- 3. What differences exist among school boards with respect to their systems for the formal evaluation of principals? -- 4. What are the perceptions of superintendents, assistant superintendents, principals, and vice-principals in a sample of school districts regarding current programs and how they can be approved? -- 5. What use is made of evaluation results in these selected districts? -- 6. What procedures were used by personnel in these districts in developing their evaluation systems? -- 7. What suggestions should be made for future developments in the area of principal evaluation in Newfoundland and Labrador? -- The Lawton Systems Model for Evaluation provided the theoretical framework used to examine the questions pertaining to the principal evaluation systems available in Newfoundland and Labrador. -- Data for the study were obtained from three sources: school board documentation outlining purposes, criteria, and procedures used in the evaluation of principals; interviews conducted with superintendents, assistant superintendents, and principals; and from questionnaires. The sample for the questionnaire component of the study included all superintendents, assistant superintendents, principals and vice-principals in eight randomly-chosen school boards. These eight boards were selected from a total of 19 boards reporting possession of principal evaluation systems. The collection of questionnaire data occurred during the Spring of 1983, with an overall return rate of 87.5 percent. Documentary analysis was used to describe those evaluation systems already in existence, with frequencies and comparison of means being used to analyze the questionnaire data. -- The results of the study led to the following major conclusions:  -- 1. Current practices in principal evaluation throughout the Province are generally the same. -- 2. The prime purpose for evaluation is the improvement of performance or instruction. -- 3. While current practices are generally the same, it is difficult to produce a list of criteria that would be common to all school districts. The criteria included in a principal evaluation system are determined somewhat by local conditions and requirements. -- 4. With reference to procedures for evaluation there was strongest support for the involvement of principals themselves as evaluators. All respondent groups preferred general school evaluation as a process and the conference technique as an instrument for evaluation. -- 5. The committee approach was recommended as the procedure that should be used to develop an evaluation system.


identifier: Deal, Peter Evan <https://research.library.mun.ca/view/creator_az/Deal=3APeter_Evan=3A=3A.html>   (2013) Toward a non-Abelian Atiyah-Bredon sequence.  Masters thesis, Memorial University of Newfoundland.

abstract: For a topological group G acting on a G-CW complex, the Chang-Skjelbred Lemma presents an exact sequence of equivariant cohomology groups [7]. Atiyah and Bredon determined an exact sequence that extends the Chang-Skjelbred Lemma [7]. The Atiyah-Bredon sequence holds only for torus actions, but Baird has conjectured that it can be generalized to actions by any compact connected Lie group. This work provides the necessary background in equivariant cohomology for this conjecture.


identifier: Dean, Rebecca <https://research.library.mun.ca/view/creator_az/Dean=3ARebecca=3A=3A.html>   (2012) Multimetallic lithium and chromium complexes of amine-bis(phenolate) ligands as polymerization catalysts.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The synthesis of biodegradable and/or bioassimilable plastics has been growing in importance throughout the past decade. The steadily decreasing supply of fossil fuels, coupled with increased environmental awareness, has spurred an interest in alternative, renewable feedstocks for use in a variety of applications. The plastics industry is no exception. Therefore, an investigation of lithium and chromium complexes was undertaken for the catalytic synthesis of polyesters and polycarbonates from renewable feedstocks. -- The ligands used in this thesis were tetradentate tripodal amine-bis(phenolates), where the substituents on the phenolate groups and pendant arm could be varied. The synthesis and characterization of mono- and dimeric lithium complexes was performed. The lithium complexes were then used to synthesize a series of chromium(III) complexes by two methods. Salt-metathesis and protonolysis/oxidation routes were used to produce mono- and dimeric, paramagnetic Cr(III) complexes. The isolated complexes were characterized by NMR (where appropriate), IR, UV-Vis spectroscopy, mass spectrometry, magnetometry, cyclic voltammetry and elemental analysis. In addition, an attempt was made to synthesize Cr amide and alkyl complexes of these ligands. -- The polymerization of rac-lactide to yield polylactide, was studied with lithium salts of amine-bis(phenolate) ligands. Polymerization studies found that ring-opening polymerization of rac-lactide was possible in the presence or absence of an alcohol as a co-initiator. As well, the copolymerization of propylene oxide and cyclohexene oxide with CO₂ to yield polycarbonates was investigated with chromium(III) amine- bis(phenolate) complexes. Polymers synthesized were shown to have high selectivity, great CO₂ incorporation and low polydispersities. Polymer analysis involved ¹H and ¹³C NMR, mass spectrometry, GPC, DSC and TGA.


identifier: Dearden, Philip <https://research.library.mun.ca/view/creator_az/Dearden=3APhilip=3A=3A.html>   (1975) The biogeography of Table Mountain, Bonne Bay, Newfoundland.: An investigation of plant community composition and distribution on a serpentine bedrock.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis is a phytogeographical study of Table Mountain, Bonne Bay, Newfoundland (N49°28’ W58°00’). It describes and analyzes the composition and distribution of plant communities on the serpentine bedrock of Table Mountain. Serpentine vegetation is characterized by its discontinuous nature, and stunted and unusual specimens. Research has indicated that four soil properties, low available calcium, and high magnesium, nickel and chromium contents are the dominant limiting factors for plant growth. The thesis postulates that these factors, in conjunction with other environmental variables, may be important in explaining the distribution and composition of plant communities on serpentine. -- The vegetation and soils are rigorously sampled, and the vegetation samples analyzed by a three-dimensional indirect ordination. The axis representing the major gradient of compositional change was found to be highly correlated with the amount of available calcium in the soil. The samples with the most diverse species, tallest specimens and most continuous vegetation cover, also had the greatest amounts of available calcium. This would appear to substantiate the theory that low calcium availability is a major factor in serpentine ecology, and furthermore suggest that it is a major factor in determining community composition and distribution on serpentine. -- The distribution of characteristic species, groups of species and edaphic properties are graphically presented within a two-dimensional ordination. This facilitates identification of phytosociological and edaphic relationships and permits the delimitation of six abstract phytosociological groups within the ordination. These groups are related to specific topographic situations and locations on Table Mountain, and their composition, edaphic characteristics and interrelationship discussed in detail. The serpentine vegetation is felt to be in dynamic equilibrium with the environment, and the sparsely colonized areas are no less of a climax than the continuous cover of the peatlands.


identifier: Decker, Stephen E. <https://research.library.mun.ca/view/creator_az/Decker=3AStephen_E=2E=3A=3A.html>   (2007) The human dimensions of a proposed restoration of European bison in Germany and a comparison of European expert and German public preferences for characteristics and methods of public involvement.  Masters thesis, Memorial University of Newfoundland.

abstract: Human dimensions of wildlife management research and associated public involvement tools can reduce conflicts between interest groups and help to understand public attitudes and beliefs. The proposed restoration of free-ranging European bison (Bison bonasus) in North Rhine-Westphalia, Germany presents an opportunity to explore human dimensions issues and address questions pertaining to public involvement. -- Randomly distributed questionnaires (n = 398) were used to assess attitudes and beliefs of residents surrounding the proposed restoration area. Residents from Siegen-Wittgenstein held significantly higher attitude and knowledge scores than Hochsauerlandkreis (HSK) respondents. Attitudes comprised general attitude and lifestyle impact factors. General fear of bison had greatest influence on attitudes. -- In the second aspect of the study, interviews with residents surrounding the proposed bison area (n = 246) and questionnaires distributed to European experts (n = 46) were used to assess preferences for characteristics and methods of public involvement. Few differences were found between Siegen-Wittgenstein and HSK. Significant differences were found between American and German public preferences and between European expert and German public preferences.


identifier: deGelder, Mettje Christine <https://research.library.mun.ca/view/creator_az/deGelder=3AMettje_Christine=3A=3A.html>   (2004) After apartheid: contradictory consciousness among white South African immigrants to Canada.  Masters thesis, Memorial University of Newfoundland.

abstract: In 1994 South Africa's racist apartheid policies, implemented since 1948 by the Afrikaner National Party, were officially dismantled and a new democratic government, led by the African National Congress, was established in its place. The events leading up to this transition, as well as its consequences, have generated an out-migration movement on the part of white South Africans. The fieldwork that I conducted in southern Ontario focused on the two major transitions that white South African immigrants to Canada, both British and Afrikaner, have experienced: the 1994 political transition in South Africa, and their international migration to and settlement in Canada. In the thesis, I analyze the memories and discourses that informants produced concerning these two transitions. Drawing on the work of Pierre Bourdieu (1977), Antonio Gramsci (1971), and Michel Foucault (1977, 1980), I demonstrate how the hegemony of apartheid shaped the lives of white South Africans. However, their stories are also indicative of a contradictory consciousness in light of apartheid oppression and its continued legacy in South Africa, generating counter-discourses that seek to oppose apartheid logic (Gramsci 1971). Pan I of the thesis, entitled 'White South African Experiences of Transition,' examines informants' memories of having grown up with nonwhite servants, as well as their privileged status as adult employers of nonwhite servants. I then consider discourses of subjectivity and violence concerning South Africa, as they were experienced both during apartheid and in the post-apartheid years. Such discourses work productively to justify informants' choice to emigrate from South Africa. My final chapter in Part I focuses on Afrikaner migrants' memories of the Dutch Reformed Church of South Africa; a Calvinist Christian denomination that has come to be criticized for its segregationist role during apartheid. I engage with academic descriptions of Afrikaner religious life through a discussion of Afrikaner political awareness and involvement during and after apartheid. In Part n of the thesis, I draw on feminist and life story approaches in anthropology and related disciplines, analyzing 'The Stories of Two British South African Migrant Women' (Moore 1988, Leydesdorff, Passerini and Thompson 1996). The thesis contributes to an understanding of both the dominance and subjectivity inherent in the notion of whiteness (Frankenberg 1997, Hartigan Jr.1997).


identifier: Deibel, Scott <https://research.library.mun.ca/view/creator_az/Deibel=3AScott=3A=3A.html>   (2011) The effect of response cost and control of species typical behavior on a daily time-place learning task.  Masters thesis, Memorial University of Newfoundland.

abstract: Two theories, which have been hypothesized to mediate acquisition in daily time-place learning (TPL) tasks were investigated: the Response-Cost (RC) hypothesis and the Species-Typical Behaviours (STB) hypothesis. According to the RC hypothesis, rats only learn daily TPL tasks if there is high cost in either effort or time for making an incorrect choice. According to the STB hypothesis, rats learn the daily TPL tasks, however the intrusion of species typical behaviours such as patrolling mask evidence of this learning. Two experiments tested the validity of these hypotheses. Rats were trained that one lever at the end of one choice arm of a T-maze provided food in the morning and six hours later a lever in the other choice arm provided food. In Experiment 1, two groups tested the RC theory by manipulating the density of the reinforcement schedule used. A third group tested the importance of the STB by giving the rats time to patrol the maze prior to the start of the experiment. If only first arm choice data were considered there was little evidence of learning. However, both first press and percentage of presses on the correct lever, revealed of TPL in all groups tested. Unexpectedly, the low response cost group performed better than the high response cost group and the species typical behaviour group performed the worst. To control for the fact that the high response cost group was on the maze for a longer period of time than the rats in the other two groups, a second experiment was conducted. Experiment 2 also used a low response cost group and a species typical behaviour group, except these animals remained on the maze for the same amount of time as the rats in the high response cost group from Experiment 1. The additional time on the maze in Experiment 2 did not have an effect on performance. Skip session probe trials confirmed that the majority of the rats that acquired the task were using a circadian timing strategy. We outline two possible explanations which might account for the results from the present study.


identifier: Deitch, Eric <https://research.library.mun.ca/view/creator_az/Deitch=3AEric=3A=3A.html>   (2005) Cardiorespiratory modifications, and limitations, in growth hormone transgenic Atlantic salmon (Salmo salar).  Masters thesis, Memorial University of Newfoundland.

abstract: GH transgenic Atlantic salmon transgenic grew 3.6x faster than non-transgenic controls, and most aspects of their cardiorespiratory system were upregulated. For example, they had greater resting and post-stress catecholamine levels, higher post-stress haemoglobin concentrations, increased maximum heart performance, and elevated aerobic enzyme activities. However, they had a higher routine metabolic rate without a change in maximum metabolic rate (M02111ax), resulting in a decreased metabolic scope, and subsequently a lowered critical swimming speed. Overall, this study supports the theory of symmorphosis, in that most aspects of the transgenic's cardiorespiratory system are upregulated to accommodate the additional demands of higher growth and/or activity. However, the transgenics MO2max appears to be limited by their gill surface area, which was not upregulated. Further, it provides information on "their physiology that can be used to: 1) understand their needs in an aquacultural setting; and 2) infer the possible ecological consequences of their escape.


identifier: De Jong, Jeremy <https://research.library.mun.ca/view/creator_az/De_Jong=3AJeremy=3A=3A.html>   (2009) Inhibition of CaMKII disrupts the formation of long term associative olfactory memory.  Masters thesis, Memorial University of Newfoundland.

abstract: Calcium signaling is essential for the formation of mammalian associative memory, yet once in the cell the exact course of signaling taken by Ca²⁺ remains vague. The kinase known as CaMKII is highly attuned to bother the strength and frequency of Ca²⁺ influx and has been implicated in numerous memory paradigms. Moreover, its intrinsic autophosphorylating ability, which may be maintained up to an hour after Ca²⁺ influx, makes the kinase an extremely important molecule in the memory pathway. -- In the present study, I investigated the effect of inhibiting this kinase on olfactory preference learning in a neonate rat model. Normally, learning may be achieved by pairing isoproterenol (2 mg/kg) acting as an unconditioned stimulus with a conditioned stimulus odor, peppermint in this case, for 10 min.  Here I found that infusion of KN-62 into the bulbs, a CaMKII inhibitor, 10 min before training as well as 10 and 30 min after training could disrupt normal 24 hr memory. Furthermore, I also used a non-learning dose if Iso (6 mg/kg) paired with odor, and found that in this group KN-62 infusion could induce learning. -- To confirm the role of CaMKII in this study we sacrificed animals at 5 min post-training to assay phosphorylated CaMKII levels and phosphorylated CREB levels. We also performed immunohistochemistry on animals sacrificed at 10 min post training to localize the effects of CaMKII and the distribution of the kinase in the olfactory bulb. -- Western blot analysis revealed that KN-62 reduced phosphorylated CaMKII levels in non-learning Iso 2(mg/kg) animals as hypothesized. Immunohistochemistry findings revealed a high CaMKII presence in the olfactory bulb, especially in the external plexiform layer and glomerular layer. KN-62 infusion decreased phosphorylated CaMKII expression in all layers of the olfactory bulb. -- In this study, we conclude that disruption of CaMKII during the early stages of memory consolidation, up to 30 min after training, in PND 6 rat pups may prevent the formation of long term memory.


identifier: Delaney, Brian J. <https://research.library.mun.ca/view/creator_az/Delaney=3ABrian_J=2E=3A=3A.html>   (2007) Globalization, China and the implications for the Newfoundland and Labrador fishing industry.  Masters thesis, Memorial University of Newfoundland.

abstract: This report reviews issues associated with globalization and specific challenges to the seafood sector in Newfoundland and Labrador. China has emerged as a major fish processing nation and is challenging developed nations. Low labour rates, high capital utilization rates and easy access to capital make China a formidable competitor. At the same time, inefficiencies within the Newfoundland and Labrador inshore sector challenge the industry to respond in this difficult environment. The industry has begun to adjust, however, structural challenges remain and this will likely limit the ability of the industry to adjust in the long term. This has implications for the long term survival of many fisheries dependent communities in this province.


identifier: Delaney, Leanda Marie <https://research.library.mun.ca/view/creator_az/Delaney=3ALeanda_Marie=3A=3A.html>   (2006) Fish community ecology in relation to land use and lotic parameters in the Mnembo River catchment (southern Africa).  Masters thesis, Memorial University of Newfoundland.

abstract: Endorheic Lake Chilwa is one of the most productive lakes in Africa, contributing up to 24% of total fish production in protein-starved Malawi. High population density and agricultural practices in the Chilwa catchment have been linked to declines in the number and size of the commercially important Barbus species. The Mnembo River is a major inflow into Lake Chilwa which has received little scientific study to date. In 2003/2004, water quality parameters and fish abundance and distribution were monitored monthly at 3 sites in the Mnembo River to provide data for a lake management plan. Studies on smaller inflows into Lake Chilwa have implicated sediment yield, discharge, conductivity and total suspended solids (TSS) as influences on Barbus migration. Barbus catch was negatively correlated with discharge and pH in the Mnembo River. Female Barbus spawning condition (Gonadosomatic Index) was positively correlated with rainfall and water temperature and negatively correlated with TSS concentrations. Within Lake Chilwa's watershed, sediment yield in the Mnembo River (56t km⁻²yr⁻¹) was significantly lower than in the Likangala (374t km⁻²yr⁻¹) and Demasi Rivers (315t km⁻²yr⁻¹) likely due to lower agricultural activity in the Mnembo catchment. Elevated rates of soil loss (0.30t km⁻²yr⁻¹) in the Mnembo catchment were mainly attributed to steep slopes rather than poor land use practices as is the case in the Likangala and Demasi catchments. Compared to Lake Chilwa's other catchments, the Mnembo River catchment is in better condition, however current land use practices will cause degradation to rapidly increase until a sustainable management strategy for the Lake Chilwa watershed is implemented.


identifier: Delaney, Marcianna Ptak <https://research.library.mun.ca/view/creator_az/Delaney=3AMarcianna_Ptak=3A=3A.html>   (2005) Pelagic cold ocean microbial dynamics and small-scale turbulence interactions with special reference to bacteria.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The marine microbial food web is a major source of biogenic carbon cycling within the world's oceans. Phytoplankton consume carbon dioxide and produce dissolved organic matter that is absorbed by the bacteria, thus stimulating bacterial growth and providing a valuable food source to micrograzers. It is believed that the energy of large scale turbulent events is propagated to ever smaller scales and can affect and influence the activity of microbial grazers. Little research exists today regarding this effect, and even less is known about how turbulence may affect the microbial food web in cold oceans in particular. Therefore, this investigation was designed to observe the combined effects of low temperature and small-scale turbulence on the microbial food web. -- The role of bacteria and the microbial food web within a polar region was examined as part of a multi-year (1997-1999) seasonal study of the North Water polynya (NOW). Regions of the polynya were characterized into two distinct water masses: the silicate-rich Arctic water (SRA W) that flowed from the north and down the coast of Ellesmere Island and the Baffin Bay water (BBW) that flowed from the south and up along the coast of Greenland. Bacterial abundances were generally higher in the BBW region than the SRA W region of the polynya. Bacterial growth rates were found to be higher rates in the SRA W region of the NOW. It was also found that bacterial biomass was positively correlated with phytoplankton biomass and negatively correlated with both inorganic nutrients. Bacterial grazing mortality exceeded growth during high turbulence treatments and that bacterial production tended to be higher in the low turbulence treatment relative to the static and high turbulence treatments. These results thus suggest that bacterioplankton are actively growing and are actively grazed within the NOW, that turbulence does have an effect on bacterial grazing mortality even at low (≤ 1°C) temperatures and that there are regional differences in the pelagic food web structure and the patterns of biogenic carbon export in the NOW as the summer progresses. -- In addition, an enclosure experiment was carried out with natural seawater of Logy Bay, Newfoundland to determine the effects of turbulence on heterotrophic and autotrophic growth in the presence and absence of micrograzers. The experiment was conducted in February and April, with water temperatures at 0°C and 5°C, respectively. There was no difference in bacterial growth between the static and turbulent enclosures in either the presence or absence of micrograzers at both experimental temperatures. Heterotrophic nanoflagellate growth was found to be significantly higher at 0°C in the presence of turbulence but only when micro grazers were absent. A similar pattern was found with the small autotrophic community at 0°C, as determined by chlorophyll a <5 µm, in which growth was significantly higher with turbulence but only when micrograzers were absent. Turbulence significantly enhanced growth rates of the large autotrophic community (>5 µm chl a) both in the presence and absence of grazers. These results suggest that turbulence effects are small under cold ocean conditions, but increase with the size of the organism. It thus appears turbulence could affect patterns of biogenic carbon export differentially, dependent upon the size structure of the plankton community.


identifier: Dempson, J. B. <https://research.library.mun.ca/view/creator_az/Dempson=3AJ=2E_B=2E=3A=3A.html>   (1982) Ecology and comparative population dynamics of anadromous Arctic charr, Salvelinus alpinus (Linnaeus 1758), in northern Labrador.  Masters thesis, Memorial University of Newfoundland.

abstract: Biological characteristics and population dynamics of northern Labrador anadromous Arctic charr (Salvelinus alpinus) were investigated. Univariate and multivariate statistical analyses were performed on nine meristic and thirteen morphometric characters of charr samples from various northern Labrador areas. Variation in meristic characters was slight, although significant differences between samples indicated the discrete nature of the stocks. Differences in growth rate, age at maturity, and movement patterns of tagged fish corroborated results of morphological analyses. -- Biological characteristics including age, growth, movement patterns and aspects of reproduction were examined in Fraser River Arctic charr. No consistent differences in growth rate were found between male and female charr. Upstream migration from the sea began in mid-July with a tendency for larger fish to enter the river first. Average size and age of upstream migrants were 45.1 cm and 8.3 years respectively. -- Biological characteristics of commercially exploited and unexploited Labrador charr populations were examined. Mean age of charr increased with latitude. Commercial exploitation has reduced the proportion of charr greater than 2.3 kg (gutted head-on weight) in commercial catches. Mean length of catches, however, has remained relatively constant in several areas. Total instantaneous mortality rates varied from 0.48 to 0.83 in exploited areas to 0.28 and 0.29 in unexploited populations. -- Comparisons between northern Labrador Arctic charr and charr from other regions are discussed with respect to movement patterns, size, age and reproductive characteristics. Labrador· charr migrated to sea for the first time at smaller sizes (7.8-19.1 cm) but comparable ages (3-7 years) with Arctic charr from other regions. Egg production in Fraser River charr was intermediate between charr from eastern and central Arctic regions, and those from the Western Arctic. Female Fraser River charr were estimated to produce 245 eggs 100g⁻¹.  Commercially exploited Labrador Arctic charr populations were generally smaller and younger than exploited charr stocks in the Northwest Territories.


identifier: Denney, Norma L. <https://research.library.mun.ca/view/creator_az/Denney=3ANorma_L=2E=3A=3A.html>   (2004) The experiences of present and former non-aboriginal teachers teaching in an aboriginal school on the north coast of Labrador.  Masters thesis, Memorial University of Newfoundland.

abstract: This study describes the life and work experiences of current and former non-aboriginal teachers working in an aboriginal school on the north coast of Labrador. Interviews with present teachers and mailed questionnaires to former teachers provided a rich description of the life and work experiences of non-aboriginal teachers in aboriginal schools. Additional information was provided from field notes compiled in the school during the course of the study. -- The major findings of this study were; a) Non-aboriginal teachers who stay working in aboriginal schools for more than two years do so because of a dedication to and concern for the students they teach; b) Non-aboriginal teachers who are open-minded, responsive to cultural challenges and demonstrate cultural sensitivity, easily adapt to community life; c) Non-aboriginal teachers who leave aboriginal schools and communities after a short period of time, do so for personal and professional reasons; d) the Labrador School Board must provide current and accurate information to prospective teacher candidates regarding aboriginal schools and communities; e) the Labrador School Board must become more proactive in dealing with teacher concerns in aboriginal schools.


identifier: Dettmer, Elke <https://research.library.mun.ca/view/creator_az/Dettmer=3AElke=3A=3A.html>   (1993) An analysis of the concept of folklorism with specific reference to the folk culture of Newfoundland.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Folklorism, an analytical concept that indicates the conscious use of folklore and refers to a variety of phenomena related to the conservation, revival and invention of traditions, has been discussed primarily among German folklorists. This thesis is an application of the concept in a North American context. Folklorism is investigated as an essentially neutral indicator of cultural processes that occur in reaction to specific social and economic conditions and change the function of folkore. In such processes folklore is purposefully used outside its original context, it is preserved, given a second existence, or newly invented according to traditional patterns. The thesis explores the historical conditions that encouraged the process of folklorism and examines the proliferation of contemporary phenomena related to folklorism in Newfoundland. These include such subjects of conventional folklore studies as the custom of mumming, the French minority culture and folk festivals which, however, are analyzed from the perspective of their ideological and commercial underpinnings. Other chapters address how the activities of folklorists themselves influence "the folk" and the related issue of their social responsibility. Particular attention is paid to tourism developments which inevitably influence the folk culture of host societies. As an analytical tool to interpret basic sociocultural processes folklorism has the potential to broaden the field of folklore by addressing social, economic and ideological trends, by integrating the academic and applied aspects of the discipline and by acknowledging the increasingly complex role folklore plays in western societies with their recent emphasis on heritage and cultural conservation.


identifier: Devereaux, Danielle <https://research.library.mun.ca/view/creator_az/Devereaux=3ADanielle=3A=3A.html>   (2005) Doing media education: the Media & Culture Screening & Discussion Series.  Masters thesis, Memorial University of Newfoundland.

abstract: The purpose of Media & Culture Screening and Discussion Series, an on-campus project created in the fall of 2003, has been to facilitate the viewing and discussion of alternative media, with a particular focus on the social role of mass media and issues of ideology, power, and the politics of representation. The following project report details the creation, execution, social context and theoretical underpinnings of the Media & Culture Screening & Discussion Series. Grounded in principles of popular critical education and a feminist social justice agenda, the Screening Series is both pedagogical and activist, and is an example of one of the ways media education might be 'done'.


identifier: Devine, Jennifer A. <https://research.library.mun.ca/view/creator_az/Devine=3AJennifer_A=2E=3A=3A.html>   (2006) Temporal trends in a large marine ecosystem.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Different scales of change imply the need for different approaches to study change in ecosystems. I determined if proximate causes for ecosystem change are apparent at different biological and spatial scales by analyzing time series at fairly short temporal scales (< 30 years). I determined whether complex dynamics involving abundance could be described for a single species whose population units are distinctly defined, for two deep-sea species, and for the demersal fish community of the northeast Newfoundland-Labrador Shelf using two newer approaches of multivariate time series analysis: minimax autocorrelation factor analysis (MAFA) and dynamic factor analysis (DFA). I analyzed trends in abundance and, for the demersal community, mean size and investigated the relationships between observed trends and external factors (environmental, exploitation and natural (non-human) predation) operating on time lags. No one factor fully explained fish population and community dynamics in the Northwest Atlantic, but rather a combination of factors operating over several temporal scales were largely responsible for the dynamics seen today. No one scale captures all the dynamics in abundance and mean size for populations, deep-sea species, or the fish community. -- Before using the techniques on deep-sea species, I wanted to determine if the data were adequate to describe trends in "non-traditional" fishery species; for this, I used generalized linear models. I discovered several deep-sea species qualified as endangered. From that analysis arose questions regarding statistical rigor: does the loss of comprehensiveness bias results? I assessed several approaches to analyzing population change that explicitly dealt with differing degrees of data filtering and the comprehensiveness of associated metrics with a detailed examination of two North Atlantic endemic deep-sea species, Macrourus berglax and Coryphaenoides rupestris. Statistical rigor is necessary, not to show that a trend exists in available data for deep-sea species, but to ensure that the trend is real. When assessing temporal trends under any conditions, ensuring the comparability of the index over time is extremely important.


identifier: Devine, Michael C. <https://research.library.mun.ca/view/creator_az/Devine=3AMichael_C=2E=3A=3A.html>   (2006) Social worker participation in organizational change: input, impacts, and commitment.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: The purpose of this case study is to elicit the perceptions of social workers of the costs and benefits related to a pervasive and rapid organizational change process. The costs and benefits are analysed within the context of an expanded version of the Bolman and Deal (1991, 1997) model for organizational analysis within a case study design. The study employs a method of triangulation in its approach to analysis. The first part of the study includes an analysis of selected government and government related documents (7 documents), primarily leading up the organizational change processes and products. The second part of the study analyzes the participants' selected experiences of the change processes as conceptualized through the use of six ( 6) quantitative questionnaires related to commitment, leadership, intention to turnover (by employees), and organizational change experiences. The population under study includes all social workers (160) in a particular organization which had experienced the integration of key selected traditional social work programs (Child Welfare, Community Living, and Youth Corrections) being integrated from a provincial government model to a community health board governed model. The third part of the study includes in-person interviews with selected participants (social workers) who had experienced the organizational change process and products (the move from the government governed model to the community board governed model). -- The results of the study demonstrated that changes were needed to improve service delivery mechanisms. The actual change process itself indicated that participants' commitment to the organization was less than adequate and that participants reported moderate to strong intentions to leave the organization. Front line leadership styles (in terms of transformational and transactional leadership) were also reported to be lacking at a time in which one would expect or hope for strong leadership qualities in all of its leaders. Finally, participants reported that they did not have the levels of input into organizational change processes and products that they would liked to have had. -- The study employs an exploratory case study design methodology. However, it does provide beginning insights into the challenges to rapid and pervasive organizational change in human services organizations. The study makes a number of recommendations regarding how the processes may be improved, as well as the implications for social work research, education, and practice.


identifier: Devraj, Ravi <https://research.library.mun.ca/view/creator_az/Devraj=3ARavi=3A=3A.html>   (2005) Interactions of fibrinogen with bovine lung surfactant extract in bulk bilayer phases and films.  Masters thesis, Memorial University of Newfoundland.


identifier: Dhanakoti, Srinivas Nagaraj <https://research.library.mun.ca/view/creator_az/Dhanakoti=3ASrinivas_Nagaraj=3A=3A.html>   (1991) Renal arginine metabolism.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

title: Renal arginine metabolism

abstract: Kidneys of normal animals remove citrulline from blood and convert it, stoichiometrically to arginine. This citrulline arises from the intestinal metabolism of glutamine. This intestinal-renal pathway constitutes the major endogenous source of arginine. The objectives of the present studies are to determine the location of arginine synthesis in kidney and its response to citrulline concentrations in vitro and in vivo and to different arginine or protein intakes in rats. -- Investigations on the localization of enzymes of arginine synthesis (argininosuccinate synthetase and argininosuccinate lyase) and of breakdown (arginase and ornithine aminotransferase), revealed that the enzymes of arginine synthesis are exclusively present in the cytosol of the cells of the proximal convoluted tubule and that of arginine degradation are enriched in other kidney regions. -- Arginine synthesis from citrulline in isolated kidney cortical tubules was found to be highly sensitive to citrulline concentrations in the physiological plasma range (0.06 mM), suggesting that renal arginine synthesis in vivo could be regulated by circulating citrulline levels. Thus, in studies on renal arginine synthesis in vivo, it was found that kidneys of rats infused with citrulline (saline-infused, as controls) responded to the elevated plasma citrulline levels by increasing its uptake and producing increased quantities of arginine. -- In studies with rats fed different levels of arginine (0.0, 0.5, 2.0%) or protein (5, 12 and 50%) for 1 week, it was found that the renal uptake of citrulline and release of arginine and also circulating citrulline levels were similar in all these animals. This suggested that renal arginine synthesis is independent of dietary arginine or protein intake. The results suggest that availability of citrulline is a limiting factor for renal arginine synthesis in rats.


identifier: Dhar, Anil <https://research.library.mun.ca/view/creator_az/Dhar=3AAnil=3A=3A.html>   (1975) Corporate dividend policy.  Masters thesis, Memorial University of Newfoundland.

title: Corporate dividend policy

abstract: The primary objective of this study was to test Gordon's model on stock valuation in forecasting common stock prices under more recent world economic climate and together find an optimum dividend rate for a selected number of Canadian Companies. -- Computer program BMDO2R was employed to perform time series multiple regression analysis on the Gordon's model of stock price valuation. Share prices were predicted only for those companies which yielded significant results. The problems of auto-correlation and multicollinearity were recognized in this study. Auto-correlation was tested by means of Von-Neuman ratio and for multicollinearity, simple inter correlations between the three independent variables (i.e. growth in dividends, dividends and size variables) were looked at. -- Two of the seven companies gave insignificant results i.e. investors in these companies did not place importance on any of the three variables considered. Two other companies yielded statistically significant results but these were not acceptable as the signs of the related coefficients were negative and beyond any reasonable explanation. Share prices were, therefore, not predicted for these four companies and an optimum dividend rate could not be determined. One other company revealed that size was the predominant factor in explaining share price. This gave only one share price as size variable was independent of the earnings retention fraction and therefore an optimum dividend rate could not be determined. (Gordon's model assumes that maximization of share price is the sole criterion in formulating dividend policy. Earnings retention fraction was the variable used to generate different share prices). Two other oil companies yielded some encouraging results. In one of them only growth in dividend variable was preferred and in the other, dividend variable was preferred share price predictions compared favourably with the actual share prices in these two companies. -- Multicollinearity was almost absent in this study. Despite the presence of auto correlation in most of the companies, the results were accepted wherever these agreed with the theory. -- Two main conclusions were drawn from this study: (1) A general approach to the formulation of (a) the share price model i.e. Eq. (16) in section 4.3 and (b) rate of return on net worth i.e. Eq. (18) in section 4.3, cannot be taken as shown by the results obtained in this study. Therefore, for each company, variables affecting the share price need to be identified through trial and error. (2) Companies in which investors prefer growth in dividends, should retain the maximum possible amount of earnings and in companies where dividends are preferred, maximum possible amount of earnings should be distributed through dividends. Maximization of share price, however, has to be the sole criterion in formulation of dividend policy, for the above arguments to hold good.


identifier: Dick, Jerry <https://research.library.mun.ca/view/creator_az/Dick=3AJerry=3A=3A.html>   (2011) Making the Newfoundland outport.  Masters thesis, Memorial University of Newfoundland.

title: Making the Newfoundland outport

abstract: The outport, a term that describes all of Newfoundland's coastal communities, is an important touchstone in terms of Newfoundland cultural identity. There is a perception by many that the 1992 Moratorium on Northern Cod marked the end of a traditional way of outport life largely centred on the family-based inshore cod fishery. This thesis explores various texts — literary, archival, and scholarly — which reveal that the outport has always been a dynamic, evolving place that is "made" on many different levels and at various locations. It also surveys some of the literature on place making, particularly as it relates to rural locations, considering such concepts as rurality, gentrification, the shift from places of production to pIaces of consumption and "the commons." Access to the commons — which is considered here not only as shared physical space but also as social space in which residents come together to produce community — is seen as an important characteristic of outport communities. -- The community of Freshwater, Conception Bay, is used as a case study to examine place making in a contemporary Newfoundland outport, and to document the transformation that it, like many rural Newfoundland communities, has undergone. This thesis concludes with a discussion about various strategies for maintaining those key characteristics that define outport communities and for managing change.


identifier: Dickinson, Alice <https://research.library.mun.ca/view/creator_az/Dickinson=3AAlice=3A=3A.html>   (2011) All things are don(n)e in time: temporality and the sick body in John Donne's Devotions upon emergent occasions.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis has no abstract.


identifier: Dickson, Mary-Lynn <https://research.library.mun.ca/view/creator_az/Dickson=3AMary-Lynn=3A=3A.html>   (1986) A comparative study of the pelagic food webs in two Newfoundland fjords using stable carbon and nitrogen isotope tracers.  Masters thesis, Memorial University of Newfoundland.

abstract: A comparative study was initiated to investigate the role of environmental variability on the trophic organization and structure of pelagic food chains in two fjords, Bay d'Espoir and Fortune Bay, along the south coast of Newfoundland, Canada. Although in close proximity, these fjords are biologically and physically distinct. On the basis of physical oceanographic studies, Bay d'Espoir was considered to be a relatively constant environment, while Fortune Bay had a dynamic water column, undergoing bi-annual deep-water renewal. Fauna, particulate organic matter (POM) and sediment were collected during summer and winter and analyzed for their stable carbon and nitrogen isotopic compositions. -- This study entailed the elucidation of the trophic organization of the most complex ecosystems yet analyzed using dual stable isotope tracers. Stable carbon and nitrogen isotopes used in combination provided better resolution than either could have given singly. However, they only allowed the assignment of species to a trophic level and did not in themselves provide information on the linkages between and within levels. -- The structure of the pelagic food webs and their principal food chains were determined for winter and summer. The trophic organization of the food webs was similar in both fjords within and between seasons; however, differences were observed in the food chains. With the exception of Bay d'Espoir in August, the top predators in both fjords occupied the fourth trophic level. The isotope data indicated which species were at intermediate trophic levels and the trophic position of the microzooplankton. -- Three pelagic food chains were present in Bay d'Espoir during both seasons, while Fortune Bay had three in the winter and two in summer. On the basis of the carbon and nitrogen isotopic composition of the fauna and POM it is suggested these pelagic food chains are affiliated with specific water types. This study is the first to draw attention to a relationship between the isotopic composition of the fauna and POM deeper than the subsurface layer. -- The trophic composition of the fauna differed between the two fjords; carnivores were dominant in Bay d'Espoir, while omnivores prevailed in Fortune Bay. A decrease in the proportion of omnivores in Fortune Bay was found between seasons, due to increased water column stability in the summer. -- A progressive enrichment of ¹³C and ¹⁵N in the fauna was found with increasing trophic level. Trophic level enrichments calculated for each food web varied slightly between fjords and seasons. These values corresponded closely to those reported in the literature and suggest similar mechanisms are involved in the fractionation of stable isotopes in food chains, independent of geographic location. Although minor differences were noted in the food chains, the overall trophic organization of the two fjords was similar to the Bering Sea (McConnaughey 1978) and the Scotian Shelf (Mills and Fournier 1979, Mills et al. 1984) ecosystems. This confirms the claims of Dickie (1972) and Mills (1975) that coastal ecosystems in general are similarly structured.


identifier: Dieleman, Susan <https://research.library.mun.ca/view/creator_az/Dieleman=3ASusan=3A=3A.html>   (2005) A new language for feminist philosophy: feminism, postmodernism, and the linguistic turn.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis seeks to consider the potential that an analysis of the feminist-postmodernist debate in light of the linguistic tum may hold. To date, very few feminist theorists have directly engaged with the linguistic tum, even though this most recent revolution in philosophical thought has drastic implications for theory itself, and more importantly, for theory that seeks to influence or describe political engagement. In Chapter One, I begin by outlining the significance of the linguistic tum in the development of the postmodern agenda. I then explore the difficult terrain of the tense relationship between feminism and postmodernism in Chapter Two. Finally, in Chapter Three, I critically analyse the way in which viewing the feminist-postmodernist debate in light of the imperatives of the linguistic turn can help to ease the tensions that have clouded this relationship from its very outset. By examining three major aspects of postmodernism upon which feminist theorists concentrate - the subject, history, and metaphysics - I attempt to locate where each theorist is positioned in relation to both the linguistic tum and postmodernism. I conclude that, even though contemporary feminist theory works within the horizon of the linguistic tum, many feminist theorists have not embraced the imperatives that come along with it. Indeed, many feminist theorists who advocate an alliance with postmodernism, still retain vestiges of representational knowledge within their philosophical systems, which is incompatible with taking the linguistic tum. I end by considering the epistemological options that are available after the demise of the episteme of representation, arguing that any feminist theory that seeks to influence or describe feminist political action, must maintain an epistemological basis.


identifier: Ding, Huakun <https://research.library.mun.ca/view/creator_az/Ding=3AHuakun=3A=3A.html>   (2007) Surface deformations in vaidya spacetimes.  Masters thesis, Memorial University of Newfoundland.

abstract: The geometry and dynamics of black hole horizons can be easily studied by considering the allowed deformations of their foliating two-surfaces. This article presents a new method of calculating the geometry and deformations of two-surfaces embedded in spacetimes. The calculations are tested by comparing the results obtained with this method with some known results about these objects. By this method, the deformations of future outer trapping surfaces in Vaidya spacetimes are studied.


identifier: Ding, Zhihu <https://research.library.mun.ca/view/creator_az/Ding=3AZhihu=3A=3A.html>   (2004) Characterization of the novel transcriptional regulator human mesoderm induction early response gene 1 (hMI-ER1): its promoters, interacting proteins and transcriptional regulatory functions.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Mesoderm induction early response 1 (mi-er1), previously called er1, was first isolated as a novel fibroblast growth factor-regulated early-response gene from Xenopus embryonic cells induced to differentiate into mesoderm. The human orthologue of xmi-er1, hmi-er1, was found to have ubiquitous, but low level, expression in normal human tissues (Paterno et al., 1998; Paterno et al., 2002). Breast carcinoma cell lines and tumours, on the other hand, showed elevated levels (Paterno et al., 1998), suggesting that hmi-er1 expression is associated with the neoplastic state in human breast carcinoma. Structurally, hMI-ER1 has conserved domains found in a number of transcriptional regulators, including an acid activation domain (Paterno et al., 1997), an ELM2 domain (Solari et al., 1999) and a signature SANT domain (Aasland et al., 1996). -- My hypothesis is that hMI-ER1 may be a potent transcriptional regulator, and deregulation of its expression and/or functions may contribute to tumorigenesis. The purpose of this project was to: (1) isolate and characterize the hmi-er1 promoters; (2) investigate the role of hMI-ER1 in transcriptional regulation; and (3) identify and characterize hMI-ER1-interacting proteins. -- Cloning and sequence analysis of one of the hmi-er1 promoters, P2, showed the absence of a TATA box, but presence of a CpG island, multiple Sp1 binding sites, and other factor binding sites which may be important in the regulation of gene expression. Functional characterization of the promoter revealed that Sp1 binds to the promoter and plays a positive role in the regulation of the P2 promoter activity of hmi-er1. hMI-ER1 was found to function as transcriptional repressor on the G5TKCAT promoter by recruitment of HDAC1 via the ELM2 domain. hMI-ER1α and β also function as transcriptional repressors on their own P2 promoter, through interaction with Sp1 and interference with the Sp1-DNA binding via the SANT domain. In order to better understand the function of hMI-ER1, an attempt was made to identify more hMI-ER1 interacting proteins by yeast two-hybrid cDNA library screening. HSP40 and TRABID were identified as proteins that interact specifically with hMI-ER1α and β. Furthermore, hMI-EMR1α and β were found to interact with the tumour suppressor RB and may participate in cell growth regulation. These results suggest that hMI-ER1 may function as a transcriptional regulator, through distinct mechanisms, to regulate cellular functions.


identifier: Ding, Zhihu <https://research.library.mun.ca/view/creator_az/Ding=3AZhihu=3A=3A.html>   (1999) Role of apoptosis in multidrug resistance and tumorigenesis of human cervical cells: implication of BAG-1 and other apoptotic proteins.  Masters thesis, Memorial University of Newfoundland.

abstract: Recent studies have indicated that inhibition of apoptosis may play an important role m both multistep carcinogenesis and multidrug resistance (.MDR). Apoptosis is controlled through many cellular genes. The pattern of these apoptosis-regulating proteins varied in different cell types. The molecular mechanism of apoptosis in the multistep carcinogenesis and multidrug resistance of cervical cells is still poorly understood. -- To examine the role of apoptosis in tumorigenesis and chemoresistance of human endocervical cells, a cisplatin-resistant endocervical cell line (HEN-16-2/CDDP) was established by treating an HPV16-immortalized human endocervical cell line previously established in this lab, HEN-16-2, with cisplatin. A phenotype of MDR was identified for HEN-16-2/CDDP by clonogenic survival efficiency assay using two structurally and functionally distinct anticancer drugs: cisplatin and paclitaxel. -- The thresholds to undergo apoptosis of HEN-16-2/CDDP cells in response to various apoptotic stimuli was compared with that of its parental HEN-16-2 cells. HEN-16-2/CDDP cells were found to be significantly more resistant to cell death induced by several chemotherapeutic drugs, UV irradiation, anti-Fas antibody and heat shock. Moreover, the dysregulation of apoptosis in HEN-16-2/CDDP cells was found to confer tumorigenicity. Further characterization of HEN-16-2/CDDP cells indicated the following: 1) they displayed distinct morphologies in monolayer; 2) they had an increased rate of proliferation in medium containing physiological calcium levels; 3) they demonstrated anchorage-independent growth in vitro; 4) they expressed similar levels of pro-apoptotic genes, including p53, Bak, Bax and the anti-apoptotic gene Bcl-2, compared to the drug-sensitive cell line, HEN-16-2; and 5) they expressed significantly higher levels of the anti-apoptotic gene Bcl-XL as well as the p50 and p33 isoforms of BAG-1. Overexpression of BAG-1 in cervical carcinoma C33A cell line confers resistance to cisplatin, etoposide and doxorubicin, but not to actinomycin D and paclitaxel BAG-1 also protects C33A cells from apoptosis induced by heat shock and UV irradiation. -- The yeast two-hybrid system was established to screen BAG-1 interacting proteins from a human keratinocyte cDNA library. Eighteen positives were obtained from 2.5 x 106 clones. Further analysis of the interacting clones identified four genes: Hsp 70, Hsp70-2, Hsc70 pseudogene and a putative novel Hsp70Y. Carboxyl-terminal amino acids of BAG-1 were found to be important in the mediation of the interactions. -- Overexpression of Hsp70 or Hsp70-2 in C33A cells conferred the resistance to various apoptotic stimuli, including cisplatin, doxorubicin, etoposide, paclitaxel, actinomycin D, heat shock and UV irradiation. -- In summary, this study provided the first in vitro evidence that inhibition of apoptosis conferred MDR and tumorigenesis in endocervical cells. Increased levels of Bcl-XL and BAG-1 p50 and p33 isoforms were found to be associated with this phenotype. Hsp70s were identified as BAG-1-interacting proteins from a cDNA library using the yeast two-hybrid system, and further studies indicated that they may also contribute to the regulation of apoptosis.


identifier: Dinn, Nicole Agnes <https://research.library.mun.ca/view/creator_az/Dinn=3ANicole_Agnes=3A=3A.html>   (2006) An examination of ballistic movement and ballistic resistance training.  Masters thesis, Memorial University of Newfoundland.

abstract: Training specificity refers to exercises designed to improve a particular function or movement in a sporting situation. Training specificity is advocated for many sports and includes velocity, joint angle and range of motion specific components. The neural adaptations that occur with training include changes in recruitment and rate coding, antagonist co-contractions, and cross-education. During explosive contractions, which are often seen in a sport setting, muscle activation as monitored with electromyography (EMG) will exhibit a triphasic burst pattern. This pattern serves to augment the movement being produced. The present study included the use of velocity specific training and the intent to contract explosively to improve punch training. Subjects were measured on force production, EMG, movement and reaction time, and coordination. Main findings included a decrease in movement time with dynamic training, and impaired coordination with isometric training. Neural adaptations, demonstrated by changes in EMG, were also found. Because of its specificity of movement, dynamic training may be a more appropriate method to improve punching speed and co-ordination for martial artists and boxers.


identifier: Dixon, Pamela <https://research.library.mun.ca/view/creator_az/Dixon=3APamela=3A=3A.html>   (1983) Rapid smoking and self-management training: a controlled comparison of relative efficacy in the treatment of dependent cigarette smokers.  Masters thesis, Memorial University of Newfoundland.

abstract: The relative efficacy of rapid smoking and self-management procedures employed alone and in combination were compared with an attention-control condition in a program to reduce cigarette smoking. Thirty-three smokers were randomly assigned to one of the four treatment groups and attended eight treatment sessions over a 5-week period. There were no differences between treatments in the proportion who stopped smoking or the mean reduction in smoking at the end of treatment and at 1-year follow-up. The overall proportion who stopped smoking was 44% at the end of treatment and 26% at 1-year follow-up. These results, contrary to prediction, fail to support the superiority of the behavioral techniques over simple support. It is suggested that greater attention be paid to the potential efficacy of social support in future research on the modification of smoking behavior.


identifier: Dlamini, Steven C. <https://research.library.mun.ca/view/creator_az/Dlamini=3ASteven_C=2E=3A=3A.html>   (2013) Age-related differences in thrombin generation using a mathematical model.  Masters thesis, Memorial University of Newfoundland.

abstract: Quantitative differences in the coagulation system in children and infants, compared to adults, are well known. The purpose of this study is to investigate the coagulation system in children and infants and to examine the effect of the differences in protein levels on the resulting thrombin generation using a mathematical model. A mathematical model consisting of 77 ordinary differential equations, each representing the concentration of a specific protein, is used for this work. Thrombin-related output variables, including: endogenous thrombin potential (ETP), peak, time to peak, and initiation phase duration are presented and discussed. -- The results of the study confirm literature reports that thrombin generation in children is both delayed and reduced compared to adults. Finally, the unknown impact of quantitative differences on the potential anticoagulant drug anti-thrombin heparin (ATH) on thrombin generation is examined for all age groups. Different ATH points at which thrombin generated is satisfactorily low (less than 100 nM·sec) were found for each age group, with increasing ATH resulting in decreased thrombin generated (ETP), at a rate inversely proportional to age. The principal conclusion is that ATH has a higher ability to suppress thrombin formation in children than in adults, hence lower amounts of ATH might be needed for antithrombin therapy in children and infants.


identifier: Dodge, M. Elaine <https://research.library.mun.ca/view/creator_az/Dodge=3AM=2E_Elaine=3A=3A.html>   (2006) Factors contributing to adult DRG neurotrophin-independent neuronal survival.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Understanding mechanisms of cellular survival in the adult dorsal root ganglion (DRG) neuron is important in identifying targets for disease intervention and treatment in the peripheral nervous system (PNS). I have used DRG neurons to study signal transduction mechanisms involved in adult DRG neurotrophin-independent survival and response to stressful stimuli to understand mechanisms of neuroprotection and to enhance cellular survival after insult so that other processes, such as regeneration, can occur. -- Dorsal root ganglion (DRG) sensory neurons become less dependent upon neurotrophins for their survival as they mature. In Chapter 2 we show that adult DRG sensory neuronal cultures are able to survive for at least two weeks in culture in the absence of nerve growth factor (NGF). The use of pharmacological inhibitors of cellular signalling pathways confirmed the importance of the phosphoinositide kinase-3 (PI 3-K) and protein kinase C (PKC) pathways in this neurotrophin-independent neuronal survival. -- Chapter 3 shows concurrent studies investigating the role of stress-activated signalling pathways and the small heat shock protein, Hsp27, in protecting PC 12 cells from heat shock (HS) and NGF withdrawal-induced apoptosis. PC 12 cells and a stable cell line overexpressing Hsp27 (HSPC cells) were subjected to a physiological heat stress. Hsp27 associated with Akt and p38MAPK after stress and HS resulted in rapid activation of Akt followed by p38MAP kinase signalling, with phosphorylation and intracellular translocation of Hsp27 also detectable. Hsp27 protected NGF-differentiated PC12 cells against NGF-withdrawal treatment and phosphorylation of Akt was maintained in both the heat-shocked and NGF-withdrawal treated HSPC cells compared to the parental cells. -- Our studies of Hsp27 in PC 12 cells formed the basis for the experimental work outlined in Chapters 4 and 5. We investigated the possibility that Hsp27 may contribute to adult DRG neurotrophin-independent survival. Unlike adult DRG neurons in vitro, neonatal DRG neurons require NGF for survival; withdrawal of NGF results in apoptosis of a majority of neonatal neurons. Constitutive Hsp27 expression was higher in adult DRG neurons compared to neonates. After HS, Akt activation and upregulation of Hsp27 expression occurs in both adult and neonatal neurons. Increasing endogenous Hsp27 by HS in neonatal neurons was able to inhibit NGF withdrawal-induced apoptosis. Hsp27 siRNA treatment of adult neurons effected a decreased expression of Hsp27, which correlated with increased apoptosis. Hsp27 siRNA also blocked the HS-induced rescue of neonatal neurons after NGF withdrawal. These results indicate that physiologically induced upregulation of Hsp27 is sufficient to provide some degree of neuronal protection. This induction appears to be regulated by transcriptional activation of HSF-1 as shown by HSF-1 nuclear translocation and EMSA analyses of HSF-1 binding to nuclear protein. -- These results provide further evidence that adult DRG neuronal survival depends on multiple factors; one of significant importance is Hsp27. My studies show that this protein and its interactions with other signalling intermediates play important roles in neuronal survival. Further assessment of Hsp27's protein interactions and regulation will hopefully contribute to elucidating factors important for adult DRG neurotrophin-independent neuronal survival.


identifier: Doha, Mazen <https://research.library.mun.ca/view/creator_az/Doha=3AMazen=3A=3A.html>   (2007) Design concept for a subsea wellhead subject to iceberg contact for marginal field development - Grand Banks of Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: With the key drivers of rising energy demand and increasing prices, major operators are expanding their search for new hydrocarbon reserves, moving into deeper water, more hostile environments and targeting smaller pools and more remote reserves. -- Thus, other type of challenges rise ahead, which require developing of new innovative, cost effective, and safe technology to put these fields into production. -- One of Canada's important offshore areas that is expected to feed into the continental energy market is the East Coast offshore fields located on the Grand Banks of Newfoundland and Labrador. In addition to the conventional challenges that accompany any offshore field development activity, wellhead protection from icebergs remains one of the most important challenges and takes the priority in any intended development on the Grand Banks. So far, several design strategies for iceberg risk mitigation have been suggested, and some are being already adopted, such as the glory hole concept which proved to be an efficient protection measure but at a high capital cost. -- The thesis work gives a general overview of the oil and gas industry on the Grand Banks with a focus on the various strategies and concepts for the protection of the wellheads on the Grand Banks, and their application for marginal fields' development. -- The present study favors the use of a shear link wellhead as a protection mechanism against floating and gouging icebergs, and accordingly an evaluation study was done for this system. -- A detailed structural analysis was conducted, by performing a study to determine the wellhead section stresses generated due to a floating /gouging iceberg wellhead accidental interaction. The response of the well upper section (conductor and wellhead) to ice gouges and to floating icebergs events was analyzed by a 3-D finite element numerical model using ABAQUS software. The parametric computations and creation of the ABAQUS input file employed a MATLAB code. The result was a better understanding of the interaction mechanism between floating/ gouging icebergs, soil mechanics and the subsea wellhead sections, where not much detailed engineering, structural and analytical work has been done previously. -- The calculated stresses and their distribution along the wellhead sections were used to address the structural reliability and integrity of the well by highlighting the stress levels and loads on: the down-hole safety valves, the isolation valve on top of the hanger, the conductor stress limit (buckling), completion tubing stress limits (buckling and rupture), the shear key and the wellhead components. Another purpose for this analysis was to present a guide for the detailed engineering, which is not addressed in this thesis, of the shear link and the suggested isolation valve on top of the tubing hanger. -- A detailed overview of well structure (Casing and Completion) and sealing barriers failure modes leading to leak paths and loss of well integrity is presented in the work where the probability of a leak occurrence in the event of X-mas tree displacement in the suggested system is done. Suggested intervention and work-over sequence to put the well into production following the event of an iceberg impact to the wellhead leading to the loss of the X-mas tree and the upper part of the well was discussed taking into consideration the safety of the operation and highlighting the practicality of the shear link wellhead system.


identifier: Donahoe, Eileen Marie <https://research.library.mun.ca/view/creator_az/Donahoe=3AEileen_Marie=3A=3A.html>   (1983) Loneliness and social skills of male college students.  Masters thesis, Memorial University of Newfoundland.

abstract: Evidence has suggested that there are behavioral differences between lonely and non-lonely people. The present study investigated the social behavior of lonely and non-lonely males in a naturalistic setting with a same sex stranger. It was hypothesized that lonely subjects would demonstrate less interest in their partners and be more anxious, hostile and depressed than non-lonely subjects. It was also hypothesized that the type of dyad subjects participated in would influence interpersonal behavior. -- Subjects were 56 male undergraduate students (mean age = 18.68). Subjects were paired in three kinds of dyads. Ten pairs were in dyads consisting of two lonely people; 10 pairs were in dyads of two non-lonely people and eight pairs were in a mixed dyad. Loneliness was categorized according to subjects' scores on the UCLA Loneliness Scale. -- Results showed that lonely subjects rated their partner's as more anxious than non-lonely subjects did (p < .05). Results also showed that the type of dyad did not affect the interaction. There were no other differences between lonely and non-lonely individuals. The results of the present study are discussed in light of methodological differences between the present and other studies and sex differences. --


identifier: Donato, Edward J. <https://research.library.mun.ca/view/creator_az/Donato=3AEdward_J=2E=3A=3A.html>   (2005) Climatic setting and phenology of Braya longii and B. fernaldii on the limestone barrens of northwestern Newfoundland.  Masters thesis, Memorial University of Newfoundland.

abstract: The endangered Braya longii and threatened Braya fernaldii are endemic to the Limestone Barrens of the Great Northern Peninsula of Newfoundland. This project determines the regional climate variability and change of the Great Northern Peninsula, and the phenology of both species of braya in response to the microclimate of the Limestone Barrens. Although mean air temperature decreases with increasing latitude along the Northern Peninsula, a consistent linear trend is not achieved. Summer and winter air temperature has been on the rise throughout the past decade (1991 to 2002). Mean winter air temperature since 1995 has been warmer than the time period from 1972 to 1995 but not as warm as the time period from 1951 to 1971. During the last 33 years, two periods of below average temperature and two periods of above average temperature can be attributed to a positive and negative NAO index respectively. The flowering phenologies of Braya fernaldii and Braya longii were significantly influenced by the date of snowmelt. Mean ground temperature was an indicator of first fruit for Braya fernaldii, but in natural substrate only. Latitude had a small influence on flowering and fruiting times of Braya fernaldii. Anthropogenically-modified substrate types favoured germination success. The results of this study provide guidance for the potential conservation management of both species of braya.


identifier: Donegan, Lawrence Patrick <https://research.library.mun.ca/view/creator_az/Donegan=3ALawrence_Patrick=3A=3A.html>   (2012) Being and time: the question concerning environmentalism.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis endeavors to determine whether Martin Heidegger's Being and Time is consistent with environmentalism. Hubert Dreyfus' characterization of Being and Time as the decisive step towards technology will provide evidence for the non-environmental character of Being and Time. Joseph Fell and W. S. K. Cameron will demonstrate an inability to reconcile Being and Time with environmentalism, and Paul Farwell will be unable to change my conception of the authentic status of producing. My exegesis of Being and Time will determine that the being-in-the-world of Dasein is understood through a technological horizon in which all entities are subordinate to a productive and pragmatic schema. What Dasein primarily encounters in the environment is not a robust understanding of nature as inherently valuable, but raw material. Thus, I will conclude that Being and Time is inconsistent with environmentalism.


identifier: Dooley, Thomas <https://research.library.mun.ca/view/creator_az/Dooley=3AThomas=3A=3A.html>   (2004) A new approach to access and allocation in the Atlantic Canadian fishery.  Masters thesis, Memorial University of Newfoundland.

abstract: The allocation of harvesting rights to individuals or fishing companies is arguably the most contentious issue facing fisheries management today. In Atlantic Canada it presents a major challenge to the Department of Fisheries and Oceans (DFO), given the complexity of the fleet structure and with several provincial and territorial jurisdictions involved. In an attempt to partially meet this challenge the Minister of Fisheries and Oceans struck the Independent Panel on Access Criteria (IPAC) in 2001. The Panel was mandated to find a solution to the decision making criteria as it relates to access with regards to ranking or weighting and defining these criteria. The IPAC final report was submitted to the Minister in March of 2002. While the report did identify principles and criteria, it failed to address completely some of the outstanding and fundamental problems associated with this complex issue. -- This paper reviews the concept of access and allocation, documents past problems, assesses the IPAC report and presents a model and process, complete with definitions and weighting, as a framework for access and allocation of fisheries resources in Atlantic Canada.


identifier: Dornan, Wayne Allan <https://research.library.mun.ca/view/creator_az/Dornan=3AWayne_Allan=3A=3A.html>   (1988) Peptidergic control of male sexual behavior: effects of intracerebrally injected substance P and cholecystokinin.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: At this point, nothing is known about how peptidergic afferents/efferents of the medial preoptic-anterior hypothalamic continuum (MPOA-AH) participate in the neural control of male rat sexual behavior. In this dissertation an attempt was made to elucidate the roles of substance P(SP) and cholecystokinin (CCK) (two peptides found within the MPOA-AH) in male reproductive behavior. In experiments 1 through 4, a variety of parameters of male copulatory behavior were recorded subsequent to intracerebral injections of SP into the MPOA-AH or the dorsal caudate/putamen (CP). Data from these experiments revealed that bilateral cannulae implanted in the MPOA-AH produced a partial lesion which disrupted the pattern of male copulatory behavior which was dependent on a post-operative test interval. Following the establishment of a new testing interval, a second series of experiments were conducted using a similar approach to that of experiments 1-4. In Experiments 8 and 9, an undiluted SP antiserum (0.3 ul or 2 ul) was injected bilaterally into the MPOA-AH. In Experiment 11, three different doses of CCK-8 (sulphated) were bilaterally injected into the MPOA-AH and the effects on male copulatory behavior following these doses were examined. Bilateral injections of 10, 100, and 200 ng/cannula, of acidified SP into the MPOA-AH significantly reduced the late3ncy to initiate copulation, while the two lower doses also reduced ejaculation latencies. In addition, all three doses of SP significantly reduced the number of mounts while the 100 ng dose also decreased the number of intromissions prior to ejaculation. In contrast to gonadally intact males, MPOA-AH injections of 10 ng of SP in castrated testosterone-deprived animals had no appreciable effect on copulatory behavior. Bilateral injections of 2 ul of a SP antiserum significantly increased mount, intromission, and ejaculations latencies and caused a significant increase in the inter-copulatory interval. In contrast to the MPOA-AH, bilateral injections of SP into the CP had no appreciable effect on male copulatory behavior. Injections of SP into the LV significantly reduced the number of intromissions to ejaculation, while at the same time lengthened both mount latencies and the inter-copulatory interval. CCK-8 injections into the MPOA-AH had no significant effect on any of the parameters of copulatory behavior, although there was a non-significant trend for reduced latencies following the larger doses of CCK-8 compared to saline injected controls. This is the first study to demonstrate that SP, a peptide previously implicated in female sexual behavior, and with a sexually differentiated distribution in the CNS, plays an important role in the neural regulation of male sexual behavior.


identifier: Doucette, Lance P. <https://research.library.mun.ca/view/creator_az/Doucette=3ALance_P=2E=3A=3A.html>   (2012) The genetic characterization of mendelian ocular disorders in the population of Newfoundland and Labrador.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: Background -- Recently, ocular genetics have shown the first successes in genetic therapies, and treatment of genetic diseases making identification of disease genes of great importance. Gene discovery is most successful through the study of genetic founder populations, such as that of Newfoundland and Labrador. -- Objective -- The objective of this thesis was to identify disease genes in three forms of Mendelian ocular disease: anterior segment dysgenesis (ASD), achromatopsia (ACHM), and microphthalmia-dwarfism (MDW). This was undertaken to find novel genes and mutations to further our understanding genetic pathways involved in each condition. -- Results -- Of the 11 families recruited for this study, 8 were solved through identification of pathogenic variants. The ASD phenotype was discovered to be caused by a novel mutation in FOXE3, seven ACHM families through mutations in CNGA3 and CNGB3, one ACHM family was found to actually have a rare disease called Jalili Syndrome through a novel mutation in CNNM4, and two MDW families helped determine a putative disease locus on 16q21. -- Conclusions -- The identification of seven mutations (two novel, five previously described) have solved the genetic etiology in eight of eleven families providing insight into the disease pathways for these families. This allows for genetic counseling and the possibility for genetically based therapies in the future.


identifier: Doucette, Laurel Catherine <https://research.library.mun.ca/view/creator_az/Doucette=3ALaurel_Catherine=3A=3A.html>   (1985) The emergence of new expressive skills in retirement and later life in contemporary Newfoundland.  Doctoral (PhD) thesis, Memorial University of Newfoundland.

abstract: While elderly people have long served folklorists as informants, scan attention has been paid to the later years as a life phase, and folklorists have been slow to consider the elderly in any role other than that of tradition bearer. This study attempts to redress this situation by examining an increasingly familiar phenomenon of later life, the adoption of a creative activity. The manifestation of creativity late in life prompts a number of questions concerning patterns of practice, factors of influence, and perceptions of personal and cultural meaning. – Interviews were conducted with a selection of ten retired or elderly Newfoundland men and women, all of whom have adopted or greatly intensified the practice of a creative activity within recent years. Live history materials and details of current practice were assembled with the aim of determining the underlying behavioural patterns of these creative seniors, and the relationships between these patterns, the aging process, and local traditional culture. – The data collected suggests that the creative senior is an emerging rather than an existing model. Choice of activity, here ranging from visual arts and crafts to performance and written composition, was dictated by personal preference rather than by local or family precedent. For these individuals there was a strong indication that the adoption of creative work was a constructive reaction to change of stress. Such adoption may in fact indicate an existing pattern, developed over a lifetime, for coping with difficulty. – Within the lives and present activities of these individuals there are recurrent themes which indicate areas of special concern and interest. These are autobiography; integration; the preparation of a cultural legacy; status maintenance and enhancement; play; compensation; social and cultural involvement; and the creation of a personal domain. The strong presence of themes which provide benefits directed towards the personal and social development of the individual rather than towards the well-being of society suggests that folklorists, in restricting their attention to the elderly in their role as tradition bearers, have neglected important aspects of the articulation of individual late life and traditional culture.


identifier: Graham, Dougal <https://research.library.mun.ca/view/creator_az/Graham=3ADougal=3A=3A.html>   (2007) Finite-state parsing of Cayuga morphology.  Masters thesis, Memorial University of Newfoundland.

abstract: This paper presents a detailed description of the design and implementation of a computerized morphological segmentation tool for Cayuga nouns. Speakers of polysynthetic First Nations languages are presented with an array of difficulties when it comes to word segmentation and dictionary access. This program demonstrates that finite-state techniques are applicable to these morphologically complex languages and are worth further study and development in order to create useful tools for speakers and learners of thesis languages.


identifier: Down, Roger Lancelot <https://research.library.mun.ca/view/creator_az/Down=3ARoger_Lancelot=3A=3A.html>   (1972) Mount Pearl: a community study of a suburb.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis has no abstract.


identifier: Doyle, Elizabeth <https://research.library.mun.ca/view/creator_az/Doyle=3AElizabeth=3A=3A.html>   (2007) Shadow-boxing: Humean selves and moral judgement.  Masters thesis, Memorial University of Newfoundland.

abstract: In Book I part IV of the Treatise of Human Nature David Hume argues that it is impossible to have an idea of ourselves enduring the same through time. We experience many and varying transient impressions over the course of our lives and our ideas are ultimately derived from and enlivened by our impressions, he explains. Now, if an enduring idea requires an enduring impression and an enduring impression is impossible, an enduring idea of personal identity is likewise impossible. -- The implications are such that we can only ever know Hume's “self” as an historical entity and, at best, our knowledge can only ever be approximate, along the lines of" Jane is x type of person presently." Our judgements must therefore refer to varying instantiations of “self” rather than an enduring self. Assuming the authenticity and adequacy of judgements only hold so long as the judgement actually refers to the nature of the judged, judgement must prove superfluous and obsolete the moment one's identity changes.  -- Hume does attempt to allow for judgement later in the Treatise, arguing moral judgements are grounded in the sympathetic emotional responses of pleasure and pain and are refined by taking account of some general and stable points of view. Accordingly, the moral point of view must call into operation at least one sentiment common to all (normal) persons, otherwise it would not succeed in bringing everybody's judgements into agreement.  -- Given these  considerations, I argue that (1) Hume's moral stance ultimately has its basis in our perceptions of another, insofar as it assumes that you or I can know what it is like to be that person. As such, it does not give us neutrality but rather a situated impartiality, and (2) Supposing our knowledge of another's nature can only ever be approximate and our judgements vague, the nature of Humean selves must necessarily elude comprehensive understanding, which leads me to (3) Selves can only ever be described on Hume's line, not judged.


identifier: Columbus Doyle, Erin <https://research.library.mun.ca/view/creator_az/Columbus_Doyle=3AErin=3A=3A.html>   (2005) The community is the culture: festivity, community identity and ethnicity at the Antigonish Highland Games.  Masters thesis, Memorial University of Newfoundland.

abstract: This thesis is an ethnography of the Antigonish Highland Games which have existed since 1863, hosted by the Highland Society in Antigonish, Nova Scotia. An historical perspective contextualizing the province's Scottish immigrations in the eighteenth and nineteenth centuries and the phenomenon of Highland Games in general introduces this study. Using the 1999 Games as a performance text, this event is proven a festival as elucidated by Falassi, Stoeltje, Abrahams and Bauman. The Games act as an authentic vehicle to express the community's identity. This identity is: co-operative in spirit ensuring the Games' successful presentation each year, resilient to the annual influx of tourists, and inextricably tied to the area's ethnic past by displaying participants' connection to their Scottish ancestors and history. Authentic expression of ethnicity is an integral part of Antigonish's identity. Antigonish's current ethnicity is read through Stern and Cicala's concept of creative ethnicity which contrasts with invented traditions as discussed by McKay, Trevor-Roper, Hobsbawm and Ranger.